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The map label for this gene is deoR

Identifier: 218694314

GI number: 218694314

Start: 943351

End: 944109

Strand: Reverse

Name: deoR

Synonym: EC55989_0885

Alternate gene names: 218694314

Gene position: 944109-943351 (Counterclockwise)

Preceding gene: 218694315

Following gene: 218694312

Centisome position: 18.31

GC content: 50.07

Gene sequence:

>759_bases
ATGGAAACACGTCGCGAAGAGCGTATCGGGCAGCTGCTGCAAGAATTAAAACGCAGCGATAAGTTACATCTTAAAGACGC
CGCCGCCCTGCTTGGGGTTTCGGAGATGACGATTCGTCGCGATCTGAACAACCACAGTGCGCCCGTCGTTTTGCTCGGCG
GCTATATTGTTCTGGAACCGCGCAGTGCCAGCCATTACCTGTTAAGCGATCAAAAATCCCGCCTGGTGGAAGAAAAACGC
CGGGCGGCAAAAATGGCTGCGACACTGGTAGAACCCGATCAGACTCTCTTTTTTGACTGTGGCACCACCACGCCGTGGAT
TATTGAAGCGATTGATAATGAAATCCCTTTTACCGCCGTTTGTTATTCGCTAAATACCTTTCTGGCGCTGAAAGAGAAAC
CCCATTGCCGCGCATTTCTGTGCGGTGGTGAATTTCACGCCAGCAACGCCATTTTCAAACCCATCGATTTTCAGCAAACG
TTGAATAATTTTTGCCCGGATATCGCTTTTTATTCCGCGGCGGGCGTGCATGTCAGTAAAGGCGCTACCTGTTTTAATCT
TGAAGAGTTGCCGGTAAAACACTGGGCCATGTCGATGGCGCAAAAGCATGTGCTGGTTGTCGACCACAGTAAATTTGGCA
AGGTGCGTCCGGCGCGCATGGGTGACCTGAAACGCTTTGATATTGTGGTGAGTGATTGTTGCCCGGAAGATGAGTATGTG
AAGTACGCGCAGACGCACCGTATTAAGTTGATGTATTAA

Upstream 100 bases:

>100_bases
CTGTTTTGCATTACCGATCCGCAAAGGCTGGGTGCGTGACTGATCTCTGCTAAAAAGTGTAGTATTGAGCGGCTCGCTTC
AATAACTATTCAGAGGGATT

Downstream 100 bases:

>100_bases
TGACGTATAACCGGATGACGTTTCGCGCCATCCGGTTATCAGAAGATTAAGAGAACCAGCTGCCGAACCACTGATGGAAT
TTCATCATCACGAAATCCCA

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAKMAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQT
LNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYV
KYAQTHRIKLMY

Sequences:

>Translated_252_residues
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAKMAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQT
LNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYV
KYAQTHRIKLMY
>Mature_252_residues
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAKMAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQT
LNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYV
KYAQTHRIKLMY

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=252, Percent_Identity=99.2063492063492, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1789519, Length=240, Percent_Identity=27.5, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1789829, Length=253, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788069, Length=250, Percent_Identity=21.2, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787540, Length=233, Percent_Identity=26.6094420600858, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790753, Length=243, Percent_Identity=23.4567901234568, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI226510968, Length=210, Percent_Identity=30, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789059, Length=231, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28575; Mature: 28575

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEP
CCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECC
RSASHYLLSDQKSRLVEEKRRAAKMAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHEECCCCCCHHHH
CYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQTLNNFCPDIAFYSAAGVHVSK
HHHHHHHEEECCCCCCEEEEECCEEECCCCEECCCCHHHHHHHHCCCHHHHHCCCEEEEC
GATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYV
CCEEECHHHCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCCHHEEEEEECCCCCHHHH
KYAQTHRIKLMY
HHHHHCEEEEEC
>Mature Secondary Structure
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEP
CCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECC
RSASHYLLSDQKSRLVEEKRRAAKMAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHEECCCCCCHHHH
CYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQTLNNFCPDIAFYSAAGVHVSK
HHHHHHHEEECCCCCCEEEEECCEEECCCCEECCCCHHHHHHHHCCCHHHHHCCCEEEEC
GATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYV
CCEEECHHHCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCCHHEEEEEECCCCCHHHH
KYAQTHRIKLMY
HHHHHCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]