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The map label for this gene is mngR

Identifier: 218694153

GI number: 218694153

Start: 779235

End: 779957

Strand: Reverse

Name: mngR

Synonym: EC55989_0713

Alternate gene names: 218694153

Gene position: 779957-779235 (Counterclockwise)

Preceding gene: 218694169

Following gene: 218694144

Centisome position: 15.13

GC content: 47.3

Gene sequence:

>723_bases
ATGGGACACAAGCCCTTATACCGGCAGATTGCCGATCGCATTCGTGAACAAATTGCGCGTGGCGAGCTTAAACCTGGCGA
TGCGTTACCTACCGAATCGGCATTACAAACAGAGTTTGGCGTCAGCCGGGTTACGGTGCGTCAGGCTTTGCGCCAGTTAG
TCGAGCAACAGATCCTCGAAAGCATTCAGGGCAGCGGGACTTACGTCAAAGAAGAGCGGGTCAATTACGATATTTTTCAG
TTAACCAGTTTTGATGAAAAACTGTCGGACCGTCACGTCGATACACACAGTGAAGTCCTGATATTTGAAGTGATTCCGGC
TGACGATTTTCTTCAGCAACAGCTACAAATCACCGCGCAGGATCGTGTGTGGCATGTGAAGCGCGTGCGCTATCGCAAGC
AAAAGCCAATGGCGCTGGAAGAAACCTGGATGCCGCTTGCGTTGTTCCCGGATCTCACCTGGCAGGTCATGGAAAATTCA
AAATATCACTTTATTGAAGAAGTGAAGAAAATGGTTATCGATCGTAGCGAACAGGAAATCATTCCTCTGATGCCAACCGA
AGAGATGAGCCGTCTGCTTAATATCAGCCAGACAAAGCCGATTCTTGAAAAAGTATCGCGTGGATATTTAGTTGATGGTC
GGGTGTTTGAATATAGCCGCAACGCTTTTAATACCGATGACTATAAATTTACCCTGATAGCGCAACGAAAATCATCGCGA
TAA

Upstream 100 bases:

>100_bases
CAATTTCACTTGATTGAAATTATTTGTATTGTATTTGTATTATTTACAGGATGAATTTATCGGGCATAATGGCTAAATTC
GTATTAATGAGATACTAAAA

Downstream 100 bases:

>100_bases
GCACAAAAAAGGCCATCATACGATGGCCAACCATGTCGAAACCGACAGCCCTTCGCCATTCCTGTAGAGGGAAGCGGCGA
GGGCTATTTCTTATTACAGA

Product: DNA-binding transcriptional repressor MngR

Products: NA

Alternate protein names: Fatty acyl-responsive regulator; Protein P30 [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ
LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS
KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR

Sequences:

>Translated_240_residues
MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQ
LTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS
KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR
>Mature_239_residues
GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL
TSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSK
YHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR

Specific function: Represses mngA and mngB. Regulates its own expression [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=240, Percent_Identity=99.5833333333333, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1790118, Length=224, Percent_Identity=31.25, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082252, Length=166, Percent_Identity=30.7228915662651, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788418, Length=232, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790540, Length=201, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28248; Mature: 28117

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
SIQGSGTYVKEERVNYDIFQLTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQ
HHCCCCCEEEHHCCCCEEEEECCHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
DRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIEEVKKMVIDRSEQEI
HHHHHHHHHHHHHCCCCCHHHCCCCEEECCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCE
IPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR
ECCCCHHHHHHHHCCCCCHHHHHHHHCCEEECCEEEEECCCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
SIQGSGTYVKEERVNYDIFQLTSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQ
HHCCCCCEEEHHCCCCEEEEECCHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
DRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIEEVKKMVIDRSEQEI
HHHHHHHHHHHHHCCCCCHHHCCCCEEECCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCE
IPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR
ECCCCHHHHHHHHCCCCCHHHHHHHHCCEEECCEEEEECCCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548486; 9278503; 9063979; 8905232; 7805834 [H]