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The map label for this gene is nadC

Identifier: 218693575

GI number: 218693575

Start: 118056

End: 118949

Strand: Reverse

Name: nadC

Synonym: EC55989_0102

Alternate gene names: 218693575

Gene position: 118949-118056 (Counterclockwise)

Preceding gene: 218693578

Following gene: 218693574

Centisome position: 2.31

GC content: 53.02

Gene sequence:

>894_bases
ATGCCGCCTCGCCGCTATAACCCTGACACCCGACGTGACGAGCTGCTGGAACGCATTAATCTCGATATCCCCGGCGCGGT
AGCCCAGGCGCTGCGGGAAGATTTAGGCGGAACAGTCGATGCCAACAATGATATTACGGCAAAACTTTTACCGGAAAATT
CTCGCTCTCATGCCACGGTGATCACCCGCGAGAATGGCGTCTTTTGCGGCAAACGCTGGGTTGAAGAGGTGTTTATTCAA
CTGGCAGGCGACGATGTCACCATAATCTGGCATGTGGATGACGGCGATGTCATCAATGCCAATCAATCCTTGTTCGAACT
TGAAGGCCCATCCCGCGTGCTGTTAACGGGCGAACGCACTGCGCTTAATTTTGTGCAAACCCTTTCAGGAGTTGCCAGTA
AGGTACGCCACTATGTCGAATTGCTGGAAGGCACCAACACGCAGTTGTTGGATACGCGCAAAACCTTACCCGGCCTGCGT
TCAGCTCTGAAATACGCGGTACTTTGCGGCGGCGGAGCGAATCACCGTCTGGGGCTTTCTGATGCCTTCCTGATCAAAGA
AAACCATATTATTGCCTCCGGCTCAGTGCGCCAGGCGGTCGAAAAAGCGTCCTGGCTGCACCCGGATGCGCCAGTAGAAG
TCGAAGTAGAGAATCTGGAAGAACTTGATGAAGCCCTGAAAGCAGGAGCCGATATCATCATGCTGGATAACTTCGAAACA
GAACAGATGCGCGAAGCCGTCAAACGCACCAACGGCAAGGCGCTACTGGAAGTGTCTGGCAACGTCACTGACAAAACACT
GCGTGAATTTGCCGAAACGGGCGTGGACTTTATCTCCGTCGGTGCGCTAACTAAACACGTACAAGCACTCGACCTTTCAA
TGCGTTTTCGCTAA

Upstream 100 bases:

>100_bases
GTTCTAACAACATGCAGGATCTCCTTATATGTGGTGCTAATACCCGGTTCAGAGTAGCATGTTTCTACCTTATGATTCGT
TAGCTATCTGGAGTTTTAAC

Downstream 100 bases:

>100_bases
TAGTTGACAGATTTATCCGCTCCATCGCGGGCGGATAATCTCCCCTTCCCCAACTTTCTTCGTAACGCCTCGCAAATTTC
TTGTCTTTCGCTGCAACGAA

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQ
LAGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLR
SALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR

Sequences:

>Translated_297_residues
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQ
LAGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLR
SALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
>Mature_296_residues
PPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQL
AGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRS
ALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFETE
QMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR

Specific function: Involved in the catabolism of quinolinic acid (QA)

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family

Homologues:

Organism=Homo sapiens, GI45269149, Length=272, Percent_Identity=34.5588235294118, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786299, Length=297, Percent_Identity=100, Blast_Score=604, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6321162, Length=255, Percent_Identity=32.9411764705882, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADC_ECOLI (P30011)

Other databases:

- EMBL:   L28105
- EMBL:   L20833
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   X15237
- PIR:   E64733
- RefSeq:   AP_000770.1
- RefSeq:   NP_414651.1
- ProteinModelPortal:   P30011
- SMR:   P30011
- DIP:   DIP-10293N
- IntAct:   P30011
- MINT:   MINT-1227037
- STRING:   P30011
- EnsemblBacteria:   EBESCT00000000279
- EnsemblBacteria:   EBESCT00000016406
- GeneID:   948869
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0105
- KEGG:   eco:b0109
- EchoBASE:   EB1508
- EcoGene:   EG11546
- eggNOG:   COG0157
- GeneTree:   EBGT00050000010935
- HOGENOM:   HBG751540
- OMA:   NHRIGLY
- ProtClustDB:   PRK09016
- BioCyc:   EcoCyc:QUINOPRIBOTRANS-MONOMER
- BioCyc:   MetaCyc:QUINOPRIBOTRANS-MONOMER
- Genevestigator:   P30011
- GO:   GO:0005737
- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00078

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N; SSF51690 Q_phspho_trans

EC number: =2.4.2.19

Molecular weight: Translated: 32762; Mature: 32631

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: BINDING 119-119 BINDING 176-176 BINDING 186-186 BINDING 215-215 BINDING 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATV
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEE
ITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERT
EEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCEEEECCCCEEEEECCHH
ALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
DAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCH
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
PPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATV
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEE
ITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERT
EEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCEEEECCCCEEEEECCHH
ALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
DAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCH
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7959070; 8561507; 8202364; 9278503; 2691840; 2607970; 8419294