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The map label for this gene is yjjG [H]

Identifier: 218692761

GI number: 218692761

Start: 5176098

End: 5176775

Strand: Direct

Name: yjjG [H]

Synonym: ECED1_5244

Alternate gene names: 218692761

Gene position: 5176098-5176775 (Clockwise)

Preceding gene: 218692760

Following gene: 218692762

Centisome position: 99.36

GC content: 53.24

Gene sequence:

>678_bases
ATGAAGTGGGACTGGATTTTCTTTGATGCCGATGAAACGCTGTTTACCTTTGACTCATTCACCGGCCTGCAGCGGATGTT
TCTTGATTACAGCGTCACCTTTACCGCTGAAGATTTTCAGGACTATCAGGCCGTTAACAAGCCACTGTGGGTGGATTATC
AAAACGGCGCGATCACTTCATTACAGCTTCAGCACGGGCGGTTTGAGAGCTGGGCCGAACGGCTGAACGTCGAACCGGGT
AAACTCAACGAGGCCTTTATTAATGCGATGGCGGAAATCTGTACGCCGTTGCCGGGGGCGGTTTCCCTGCTTAACGCCAT
TCGTGGCAACGCCAAAATCGGCATCATCACCAACGGCTTTAGCGCCTTGCAACAGGTACGTCTGGAACGCACGGGCCTGC
GTGATTACTTCGATTTGCTGGTGATTTCCGAAGAAGTTGGCGTTGCCAAACCGAATAAGAAAATTTTCGATTATGCGCTG
GAACAAGCGGGCAATCCTGACCGTTCACGCGTGCTGATGGTTGGTGACACTGCCGAGTCCGATATTCTCGGTGGCATCAA
CGCCGGGCTTGCGACCTGCTGGCTGAATGCGCACAATCGCGAGCAACCAGAAGGCATCGCGCCCACCTGGACCGTTTCTT
CGTTGCACGAACTGGAGCAGCTCCTGTGTAAACACTGA

Upstream 100 bases:

>100_bases
ACGAGGCGACAATTCGCCGCAATTACTACCCCACCACGGACGGTCGCGAAGACGCCATCATCATGGCGTTGCCAATCAGT
ATGTAAGACAAGGTGGAATA

Downstream 100 bases:

>100_bases
TTGCCTCCCCCCCGTTGATGGGTAAAATAGCCGCAATTTTTCGTTTTCAACAAGCGCGGCGCGATGCCGCTTACTCAAGA
AGAAAGAATTATGACGTTGT

Product: nucleotidase

Products: NA

Alternate protein names: House-cleaning nucleotidase; Non-canonical pyrimidine nucleotide phosphatase; Nucleoside 5'-monophosphate phosphohydrolase; dUMP phosphatase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLNVEPG
KLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYAL
EQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH

Sequences:

>Translated_225_residues
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLNVEPG
KLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYAL
EQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH
>Mature_225_residues
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLNVEPG
KLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYAL
EQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH

Specific function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconat

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. YjjG family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=245, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1790833, Length=225, Percent_Identity=99.5555555555556, Blast_Score=466, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR011951 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 25278; Mature: 25278

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITS
CCCEEEEEECCCEEEEEHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEEECCCCEEE
LQLQHGRFESWAERLNVEPGKLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGF
EEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCH
SALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAES
HHHHHHHHHHCCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCC
DILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH
HHHCCCCCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITS
CCCEEEEEECCCEEEEEHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEEECCCCEEE
LQLQHGRFESWAERLNVEPGKLNEAFINAMAEICTPLPGAVSLLNAIRGNAKIGIITNGF
EEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCH
SALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAES
HHHHHHHHHHCCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCC
DILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH
HHHCCCCCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]