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The map label for this gene is exuT [H]

Identifier: 218692589

GI number: 218692589

Start: 4985981

End: 4987258

Strand: Reverse

Name: exuT [H]

Synonym: ECED1_5056

Alternate gene names: 218692589

Gene position: 4987258-4985981 (Counterclockwise)

Preceding gene: 218692590

Following gene: 218692582

Centisome position: 95.73

GC content: 46.48

Gene sequence:

>1278_bases
ATGAATAAAATAAAGAATTATCGATGGCATATGATTGCCCTCGTATGCTTTATCACTGTAATCAATTATCTGGACAGAAC
GGCGTTAGGTATTGCGGCTCCAACGATTATGGAGACAACCGGAATAACCAAAGAACAATATTCATGGATTGTCAGTGCAT
TCCAGTTGGCCTATACATTGGGGCAACCGATAATGGGCTTCTTTATTGATACCGTGGGTCTGAAGTTAAGTTTTGCGATA
TGTGCCGCAATCTGGGGCCTGGCGACAATGGGGCATGCCTTGACAGGAACATGGTCAGGTCTGGCATTTATGCGCGCCCT
GATGGGTTTCAGCGAAGCATCGGCAATTCCTGCGGGTGTAAAAACCGCATCAACATGGTTCCCGGCAAAAGAGCGTGGCG
TGGCGACAGGTGTATTCAATATGGGTACCTCACTCGGCGCGATGCTTGCTCCACCGTTGATTGCCTGGTGCATTATGTTT
CATAGCTGGCAATTTGCGTTTATTGTCTCAGGTAGCCTTGCTTTACTCGCGGCTTTATTTTGGTTCTTTTGTTATAAAGA
TCCAAAAGATGCTAAACGCCTTTCTGATGAAGAGCGCCACTATATTGAGTCTGGGCAAGAACAGCATCTTAAAACAGATA
AGAAAGAAAAAACGTCAATCAAGCATATCCTCAGCCAACGTAATTTCTGGGGGATTGGCATCGCGCGTTTTCTCGCTGAC
CCGGCATGGGGAACCATTAACTTCTGGGTACCGATTTTCTTCGTCGAAACGCTGCATTTTAGCCTGAAAGAAATTGCCAT
GTTCGTCTGGCTGCCTTTCCTGCTGGGCGATCTCGGCTGTTTAGCCAGTGGTTTTGTCGCGAAGTTCTTCCACGATCGCG
GCGTGAGTTTAATTAACTCACGAAGAATTACCTTCACTATTGCAGCCGTCATTATGATGACGATTGGTCTGGTGAGTATT
GTCGAAAATCCCTACATCGCCGTATTACTGATTAGCATTGGCGCATTCTCGCATCAATGTCTTTCTACTGTTGCAGCAAC
TCTGGGCGGTGACCTATTCAAAAAAGACGAAGTAGCTACCGCTGTGGGTATGGCAGGAGCCTGTGCATGGAGCGGTCAGT
TGATTTTCAACCTGTTTATCGGGGCATTCGTTCACATTATTGGCTTCGCGCCGTTCTTTATTGCCCTGGCTTTCTTTGAC
ATTATTGGCGCCATTGCGCTGTGGATGCTTATCAAAGTTAAAGACGAAGAACCACAAGTACAGTTAGCGACAAGCTAA

Upstream 100 bases:

>100_bases
CACAATAATTTTCAATATTTCCTCTGTACCTGATTTTTATTGCCTATTACATGGAAATACCAACAACCAGGGTTTATTAA
TATAATTAAAAGGTTTAAAA

Downstream 100 bases:

>100_bases
TTATTTTACATAGAAACGCTATAATTTAGCTTTGTAGCGTTTCTATTTTTCTCATAAATTAAACGTCTCTTCCAAAACGT
TCAGTATCTACTGGCATTGC

Product: putative Hexuronate transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTLGQPIMGFFIDTVGLKLSFAI
CAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGVKTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMF
HSWQFAFIVSGSLALLAALFWFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINSRRITFTIAAVIMMTIGLVSI
VENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVATAVGMAGACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFD
IIGAIALWMLIKVKDEEPQVQLATS

Sequences:

>Translated_425_residues
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTLGQPIMGFFIDTVGLKLSFAI
CAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGVKTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMF
HSWQFAFIVSGSLALLAALFWFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINSRRITFTIAAVIMMTIGLVSI
VENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVATAVGMAGACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFD
IIGAIALWMLIKVKDEEPQVQLATS
>Mature_425_residues
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTLGQPIMGFFIDTVGLKLSFAI
CAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGVKTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMF
HSWQFAFIVSGSLALLAALFWFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINSRRITFTIAAVIMMTIGLVSI
VENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVATAVGMAGACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFD
IIGAIALWMLIKVKDEEPQVQLATS

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=338, Percent_Identity=27.5147928994083, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI9966811, Length=241, Percent_Identity=25.7261410788382, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI9945322, Length=355, Percent_Identity=25.0704225352113, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI154350196, Length=362, Percent_Identity=22.3756906077348, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI154800443, Length=269, Percent_Identity=25.6505576208178, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI148743791, Length=227, Percent_Identity=23.3480176211454, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI2367193, Length=424, Percent_Identity=47.1698113207547, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI87082320, Length=421, Percent_Identity=27.5534441805226, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789515, Length=344, Percent_Identity=27.0348837209302, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI2367379, Length=309, Percent_Identity=27.831715210356, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1789152, Length=330, Percent_Identity=23.6363636363636, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082071, Length=233, Percent_Identity=26.6094420600858, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788573, Length=436, Percent_Identity=22.4770642201835, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082310, Length=384, Percent_Identity=20.5729166666667, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552542, Length=219, Percent_Identity=26.9406392694064, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583789, Length=309, Percent_Identity=25.2427184466019, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24584153, Length=272, Percent_Identity=25.3676470588235, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641682, Length=318, Percent_Identity=24.2138364779874, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129235, Length=285, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24658666, Length=414, Percent_Identity=24.8792270531401, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550495, Length=395, Percent_Identity=25.5696202531646, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24580790, Length=177, Percent_Identity=27.683615819209, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24658658, Length=357, Percent_Identity=23.249299719888, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130167, Length=337, Percent_Identity=23.4421364985163, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573299, Length=313, Percent_Identity=25.8785942492013, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24658674, Length=408, Percent_Identity=24.2647058823529, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46844; Mature: 46844

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
GQPIMGFFIDTVGLKLSFAICAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCC
KTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMFHSWQFAFIVSGSLALLAALF
CCCCCCCCHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHHHHHH
WFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
HHHHCCCCHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCC
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RRITFTIAAVIMMTIGLVSIVENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVAT
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVGMAGACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFDIIGAIALWMLIKVKDEEPQV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCE
QLATS
EEECC
>Mature Secondary Structure
MNKIKNYRWHMIALVCFITVINYLDRTALGIAAPTIMETTGITKEQYSWIVSAFQLAYTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
GQPIMGFFIDTVGLKLSFAICAAIWGLATMGHALTGTWSGLAFMRALMGFSEASAIPAGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCC
KTASTWFPAKERGVATGVFNMGTSLGAMLAPPLIAWCIMFHSWQFAFIVSGSLALLAALF
CCCCCCCCHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHHHHHH
WFFCYKDPKDAKRLSDEERHYIESGQEQHLKTDKKEKTSIKHILSQRNFWGIGIARFLAD
HHHHCCCCHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCC
PAWGTINFWVPIFFVETLHFSLKEIAMFVWLPFLLGDLGCLASGFVAKFFHDRGVSLINS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RRITFTIAAVIMMTIGLVSIVENPYIAVLLISIGAFSHQCLSTVAATLGGDLFKKDEVAT
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AVGMAGACAWSGQLIFNLFIGAFVHIIGFAPFFIALAFFDIIGAIALWMLIKVKDEEPQV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCE
QLATS
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]