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The map label for this gene is nanR [H]

Identifier: 218692470

GI number: 218692470

Start: 4876075

End: 4876809

Strand: Reverse

Name: nanR [H]

Synonym: ECED1_4918

Alternate gene names: 218692470

Gene position: 4876809-4876075 (Counterclockwise)

Preceding gene: 218692472

Following gene: 218692460

Centisome position: 93.61

GC content: 38.91

Gene sequence:

>735_bases
ATGTCCGACAACAAAAAAACCGTGTTACCCGGGCTAACAACGACCAGAAAGCCCATTGTTACAAAAAAACTTTCAGAAAT
CGTTGCCGAAGAGCTTGAAAGAATGATCCGCCAGGAGGAGATAAGGGAAGGTGAATACCTGCCTTCTGAACGTGAACTTA
TGGCATTCTTTGGCGTTGGAAGACCATCTGTCAGAGAGGCTTTATCATCTCTCAGACATAAAGGGCTAATCCGGTATAAC
AAGGGAGAAAAAGCCAGTGTCTGCCGTCCATCACCAGAAACCATCATTAATGGGTTATCAGGCATTGTTAAAGATTTTTT
ATCTACAGCTGATGGCATCAAGGATTTTGAAAGACTACGCATCTTTTTTGAAACCAACCTTGTAAGATATGCAGCAAAAA
ATGCAACGCCTGAGGATATTCACAGGCTTGAGAAGGTGCTCAGTATCCATCATAACTCACTGAGAACCCCCGAAGTGTAT
GCTCAATATGATATTGAATTTCATAGTATACTTGCTGATATACCTGACAATAAAGTATTAAAAACAATACACTCAGCATT
TTCTGAATGGCTGATAATGGCCAAACCTCTGGAAAAGAATAAAATGACATATGAAAATAACAAAAAAACCCATCAGCAGC
ATATTGAAATACTTACGGCCATAAAAGAGCATGATTGTGATAAAGCTGAACAGCTAATGTATAATCACCTTTATAAACGA
ATTGAAGCATCATAG

Upstream 100 bases:

>100_bases
TCATCCCCCCTTTACATAATAGATTTAATTAAATATTTTCATTATTAAAAGAAAGTGTTAAATTAAAAACTCATTTGCTC
TAATCCATATAAATCAATAT

Downstream 100 bases:

>100_bases
TTACTCGACGCTTCACCAGGTAGTCACCATAAATATTATTTAAATCCATGAGAATACATCCAGTCCATAAACAGTTTTAT
CCATCCTCCAACAGGAAGAT

Product: Transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSDNKKTVLPGLTTTRKPIVTKKLSEIVAEELERMIRQEEIREGEYLPSERELMAFFGVGRPSVREALSSLRHKGLIRYN
KGEKASVCRPSPETIINGLSGIVKDFLSTADGIKDFERLRIFFETNLVRYAAKNATPEDIHRLEKVLSIHHNSLRTPEVY
AQYDIEFHSILADIPDNKVLKTIHSAFSEWLIMAKPLEKNKMTYENNKKTHQQHIEILTAIKEHDCDKAEQLMYNHLYKR
IEAS

Sequences:

>Translated_244_residues
MSDNKKTVLPGLTTTRKPIVTKKLSEIVAEELERMIRQEEIREGEYLPSERELMAFFGVGRPSVREALSSLRHKGLIRYN
KGEKASVCRPSPETIINGLSGIVKDFLSTADGIKDFERLRIFFETNLVRYAAKNATPEDIHRLEKVLSIHHNSLRTPEVY
AQYDIEFHSILADIPDNKVLKTIHSAFSEWLIMAKPLEKNKMTYENNKKTHQQHIEILTAIKEHDCDKAEQLMYNHLYKR
IEAS
>Mature_243_residues
SDNKKTVLPGLTTTRKPIVTKKLSEIVAEELERMIRQEEIREGEYLPSERELMAFFGVGRPSVREALSSLRHKGLIRYNK
GEKASVCRPSPETIINGLSGIVKDFLSTADGIKDFERLRIFFETNLVRYAAKNATPEDIHRLEKVLSIHHNSLRTPEVYA
QYDIEFHSILADIPDNKVLKTIHSAFSEWLIMAKPLEKNKMTYENNKKTHQQHIEILTAIKEHDCDKAEQLMYNHLYKRI
EAS

Specific function: Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789621, Length=227, Percent_Identity=52.4229074889868, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1790032, Length=225, Percent_Identity=26.2222222222222, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1789353, Length=213, Percent_Identity=27.6995305164319, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI48994955, Length=195, Percent_Identity=30.2564102564103, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790780, Length=225, Percent_Identity=28, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786303, Length=153, Percent_Identity=30.0653594771242, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28204; Mature: 28073

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNKKTVLPGLTTTRKPIVTKKLSEIVAEELERMIRQEEIREGEYLPSERELMAFFGVG
CCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
RPSVREALSSLRHKGLIRYNKGEKASVCRPSPETIINGLSGIVKDFLSTADGIKDFERLR
CHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFFETNLVRYAAKNATPEDIHRLEKVLSIHHNSLRTPEVYAQYDIEFHSILADIPDNKVL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHCCCHHHH
KTIHSAFSEWLIMAKPLEKNKMTYENNKKTHQQHIEILTAIKEHDCDKAEQLMYNHLYKR
HHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IEAS
HCCC
>Mature Secondary Structure 
SDNKKTVLPGLTTTRKPIVTKKLSEIVAEELERMIRQEEIREGEYLPSERELMAFFGVG
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
RPSVREALSSLRHKGLIRYNKGEKASVCRPSPETIINGLSGIVKDFLSTADGIKDFERLR
CHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFFETNLVRYAAKNATPEDIHRLEKVLSIHHNSLRTPEVYAQYDIEFHSILADIPDNKVL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHCCCHHHH
KTIHSAFSEWLIMAKPLEKNKMTYENNKKTHQQHIEILTAIKEHDCDKAEQLMYNHLYKR
HHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IEAS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA