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The map label for this gene is iucD [H]

Identifier: 218692455

GI number: 218692455

Start: 4860884

End: 4862221

Strand: Reverse

Name: iucD [H]

Synonym: ECED1_4902

Alternate gene names: 218692455

Gene position: 4862221-4860884 (Counterclockwise)

Preceding gene: 218692456

Following gene: 218692454

Centisome position: 93.33

GC content: 46.56

Gene sequence:

>1338_bases
ATGAAAAAAAGTGTCGATTTTATTGGTGTCGGGACAGGGCCATTTAATCTCAGCATTGCTGCATTGTCACATCAGATCGA
AGAACTGAACTGTCTCTTCTTTGACGAACATCCTCATTTTTCCTGGCATCCGGGTATGCTGGTACCGGATTGTCATATGC
AGACCGTCTTTCTGAAAGATCTGGTCAGTGCAGTTGCACCTACAAATCCCTACAGCTTTGTTAACTATCTGGTGAAGCAC
AAAAAGTTCTATCGCTTCCTTACAAGCAGGCTACGTACAGTATCCCGTGAAGAGTTTTCTGACTATCTCCGCTGGGCTGC
TGAAGATATGAATAACCTGTATTTCAGTCATACCGTTGAAAATATTGATTTCGACAAAAAAAGTCGATTGTTTCTGGTTC
AGACCAGTCGGGGAGAATATTTTGCCCACAATATCTGCCTTGGTACAGGAAAACAACCTTATTTACCACCCTGTGTGAAG
CATGTGACACAATCCTGTTTCCATGCCAGTGAAATGAATCTTCGTCGGCCGGACCTGAGTGAAAAACGGATAACCGTGGT
TGGTGGAGGACAGAGTGGTGCAGACCTGTTCCTTAATGCATTACGCGGGGAATGGGGAGAAGCGGCGGAAATAAACTGGG
TCTCACGGCGTAATAATTTTAACGCACTGGATGAGGCTGCTTTTGCTGATGAGTATTTTACACCTGAATATATTTCAGGC
TTCTCCGGACTGAAGGAAGATATTCGCCATCAGTTACTGGATGAGCAGAAAATGACATCGGATGGCATCACTGCCGATTC
TTTACTGACCATTTATCGTGAGTTGTACCACCGTTTTGAAGTTCTGAGAAAACCAAGAAATATCCGTCTGCTACCCAGTC
GCTCGGTAACAACTCTGGAAAGTAGTGGTCCGGGCTGGAGGTTATTGATGGAACATCATCTGGATCAGGGCAGAGAGAGC
CTGGAAAGTGATGTGGTGATTTTCGCCACAGGTTACCGTTCTGCATTGCCACAAATACTTCCCTCACTGATGCCCTTGAT
CACCATGCACGATAAGAACACCTTTAAAGTGCGTGATGACTTCACTCTGGAATGGAGTGGCCCGAAAGAAAATAACATCT
TTGCGGTCAACGCCAGCATGCAAACTCATGGCATCGCCGAACCCCAGCTCAGCCTGATGGCCTGGCGATCTGCACGTATT
CTTAATCGCGTACTGGGGCGTGATTTATTCGATCTCAGTATGCCGCCCGCACTGATTCAGTGGCGCAGCGGCAGCCGGAA
AAAACCGCAGCCGGAGGCTGCTTCTTTAACTCACTATACAGCAAATATTCAGGAATAA

Upstream 100 bases:

>100_bases
AACTGACCTGGCCGGACCTGGATGGCGGCAGTCGCATGCTGCCGAATTACCTTGAGAATCTGCAAAATCCGCTGTGGCTG
GTAACTCAGGAATATGAATC

Downstream 100 bases:

>100_bases
CGATGATGCGCAAAAAGTATATGCCCCGGGCTCTTGGTCCGCTGCTTCTTGTCGTGCTGTCACCAGCTGTCGCCCAGCAA
AACGATGATAATGAGATCAT

Product: L-lysine 6-monooxygenase

Products: NA

Alternate protein names: Lysine 6-N-hydroxylase; Lysine N(6)-hydroxylase; Lysine-N-oxygenase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKH
KKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVK
HVTQSCFHASEMNLRRPDLSEKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISG
FSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWRLLMEHHLDQGRES
LESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARI
LNRVLGRDLFDLSMPPALIQWRSGSRKKPQPEAASLTHYTANIQE

Sequences:

>Translated_445_residues
MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKH
KKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVK
HVTQSCFHASEMNLRRPDLSEKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISG
FSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWRLLMEHHLDQGRES
LESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARI
LNRVLGRDLFDLSMPPALIQWRSGSRKKPQPEAASLTHYTANIQE
>Mature_445_residues
MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKH
KKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVK
HVTQSCFHASEMNLRRPDLSEKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISG
FSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWRLLMEHHLDQGRES
LESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARI
LNRVLGRDLFDLSMPPALIQWRSGSRKKPQPEAASLTHYTANIQE

Specific function: This is one of the proteins involved in the biosynthesis of siderophores (such as the dihydroxamate siderophore, aerobactin), which are chelators that mediate the high-affinity iron transport systems induced by the organism under iron-stressed conditions

COG id: COG3486

COG function: function code Q; Lysine/ornithine N-monooxygenase

Gene ontology:

Cell location: Cytoplasm. Cell membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027 [H]

Pfam domain/function: PF07992 Pyr_redox_2 [H]

EC number: =1.14.13.59 [H]

Molecular weight: Translated: 50937; Mature: 50937

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKD
CCCCCCEEEECCCCCEEEHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
LVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHC
NIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVKHVTQSCFHASEMNLRRPDLS
CCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
EKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISG
CCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHH
FSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEE
SSGPGWRLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDD
CCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHEEECCCCEEEEECC
FTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVLGRDLFDLSMPPALIQ
EEEEECCCCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHEE
WRSGSRKKPQPEAASLTHYTANIQE
ECCCCCCCCCCCHHCEEEEECCCCC
>Mature Secondary Structure
MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKD
CCCCCCEEEECCCCCEEEHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
LVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHC
NIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVKHVTQSCFHASEMNLRRPDLS
CCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
EKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISG
CCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHH
FSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEE
SSGPGWRLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDD
CCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHEEECCCCEEEEECC
FTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVLGRDLFDLSMPPALIQ
EEEEECCCCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHEE
WRSGSRKKPQPEAASLTHYTANIQE
ECCCCCCCCCCCHHCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3275632; 10064136 [H]