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The map label for this gene is bioF [H]

Identifier: 218691269

GI number: 218691269

Start: 3557598

End: 3558770

Strand: Direct

Name: bioF [H]

Synonym: ECED1_3628

Alternate gene names: 218691269

Gene position: 3557598-3558770 (Clockwise)

Preceding gene: 218691268

Following gene: 218691277

Centisome position: 68.29

GC content: 52.43

Gene sequence:

>1173_bases
ATGGGGCTATACGATAAATATGCGCGCCTTGCTGGCGAGCGCCTGCAATTTAGTGACAACGGGTTAACACCATTTGGCAC
CTGTATTGATGAAGTGTATTCCGCCACCGAAGGCCGGATCGGCAATAAAAAAGTGATTCTGGCCGGGACCAATAATTATC
TCGGTTTAACCTTTAATCATGATGCTATCCGCGAAGGTCAGGCAGCGTTAGCGGCCCAAGGCACCGGCACCACCGGTTCT
CGTATGGCAAACGGCAGTTATGCGCCGCATCTGGCGTTAGAGAAAGAGATTGCCGAGTTTTTCAATCGCCCTACCGCTAT
CGTTTTTTCAACCGGTTATACCGCTAATTTAGGCGTCATCAGCACACTTGCCGACCATAACGCCGTGGTGTTACTGGATG
CCGACAGCCACGCCAGTATTTATGACGCCTGTTCTCTCGGCGGCGCGGAGATTATTCGTTTCCGCCATAATGACGTCAAC
GATCTGGAACGGCGCATGGTCCGCCTCGGTGAACGGGCGAAAGAGGCGATTATTATCGTTGAAGGCATCTACAGTATGCT
CGGTGACGTTGCGCCGCTGGCAGAAATTGTTGATATCAAACGTCGTCTCGGTGGTTATTTGATTGTCGATGAAGCACATT
CGTTTGGCGTGTTAGGCGCTACGGGGCGCGGACTGGCCGAAGCTGTCGGCGTTGAAGATGATGTGGATATTATCGTTGGC
ACCTTCAGTAAAAGTCTGGCCTCGATTGGCGGTTTTGCTGTCGGTTCGGAAGCGATGGAAGTGCTGCGCTACGGCAGCCG
CCCGTATATTTTTACCGCCTCTCCTTCTCCGTCCTGCATTGCGACCGTGCGCTCGTCGTTAAGAACCATTGCCTCACAAC
CAGAGCTGCGGCAAAAGCTGATGGATAACGCCAACCATCTGTATGACGGTCTGCAAAAGCTGGGTTACGAGTTAAGTTCA
CATATTAGCCCGGTAGTGCCAGTAATAATCGGTTCGAAAGAGGAAGGTTTACGCATCTGGCGCGAGCTTATTTCGCTGGG
CGTTTATGTGAATCTTATCCTGCCACCTGCCGCGCCTGCTGGCATCACGCTGCTGCGCTGTAGCGTAAACGCGGCCCACA
GTCGTGAGCAAATCGATGCCATCATTCAGGCATTTGCTACTCTGAAGCAGTAA

Upstream 100 bases:

>100_bases
AAGACAGATTCGATATTTCCATTCCTATTAATATTCTGCTGGATGTCAAAACCCCTGCGCAATTAATGGAAACTCTACTT
CCATGGCTGGAGAATAACTA

Downstream 100 bases:

>100_bases
TGTGAACCCGCCGTGGTGTTGCGCCACGGCGGGTTTAATGTTGTCTGTCATGCCAATACACCAGGCTCAACGCCACCAGC
ACAAACGCTACCGGTAAACC

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MGLYDKYARLAGERLQFSDNGLTPFGTCIDEVYSATEGRIGNKKVILAGTNNYLGLTFNHDAIREGQAALAAQGTGTTGS
RMANGSYAPHLALEKEIAEFFNRPTAIVFSTGYTANLGVISTLADHNAVVLLDADSHASIYDACSLGGAEIIRFRHNDVN
DLERRMVRLGERAKEAIIIVEGIYSMLGDVAPLAEIVDIKRRLGGYLIVDEAHSFGVLGATGRGLAEAVGVEDDVDIIVG
TFSKSLASIGGFAVGSEAMEVLRYGSRPYIFTASPSPSCIATVRSSLRTIASQPELRQKLMDNANHLYDGLQKLGYELSS
HISPVVPVIIGSKEEGLRIWRELISLGVYVNLILPPAAPAGITLLRCSVNAAHSREQIDAIIQAFATLKQ

Sequences:

>Translated_390_residues
MGLYDKYARLAGERLQFSDNGLTPFGTCIDEVYSATEGRIGNKKVILAGTNNYLGLTFNHDAIREGQAALAAQGTGTTGS
RMANGSYAPHLALEKEIAEFFNRPTAIVFSTGYTANLGVISTLADHNAVVLLDADSHASIYDACSLGGAEIIRFRHNDVN
DLERRMVRLGERAKEAIIIVEGIYSMLGDVAPLAEIVDIKRRLGGYLIVDEAHSFGVLGATGRGLAEAVGVEDDVDIIVG
TFSKSLASIGGFAVGSEAMEVLRYGSRPYIFTASPSPSCIATVRSSLRTIASQPELRQKLMDNANHLYDGLQKLGYELSS
HISPVVPVIIGSKEEGLRIWRELISLGVYVNLILPPAAPAGITLLRCSVNAAHSREQIDAIIQAFATLKQ
>Mature_389_residues
GLYDKYARLAGERLQFSDNGLTPFGTCIDEVYSATEGRIGNKKVILAGTNNYLGLTFNHDAIREGQAALAAQGTGTTGSR
MANGSYAPHLALEKEIAEFFNRPTAIVFSTGYTANLGVISTLADHNAVVLLDADSHASIYDACSLGGAEIIRFRHNDVND
LERRMVRLGERAKEAIIIVEGIYSMLGDVAPLAEIVDIKRRLGGYLIVDEAHSFGVLGATGRGLAEAVGVEDDVDIIVGT
FSKSLASIGGFAVGSEAMEVLRYGSRPYIFTASPSPSCIATVRSSLRTIASQPELRQKLMDNANHLYDGLQKLGYELSSH
ISPVVPVIIGSKEEGLRIWRELISLGVYVNLILPPAAPAGITLLRCSVNAAHSREQIDAIIQAFATLKQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=364, Percent_Identity=31.8681318681319, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI7657118, Length=337, Percent_Identity=32.9376854599407, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4758668, Length=359, Percent_Identity=31.7548746518106, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=31.5789473684211, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI83977444, Length=354, Percent_Identity=28.5310734463277, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI83977440, Length=354, Percent_Identity=28.5310734463277, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI83977442, Length=354, Percent_Identity=28.5310734463277, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI4502025, Length=362, Percent_Identity=28.7292817679558, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40316939, Length=362, Percent_Identity=28.7292817679558, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI5454084, Length=326, Percent_Identity=29.7546012269939, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1790046, Length=347, Percent_Identity=33.7175792507205, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=32.7586206896552, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=351, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI32566772, Length=372, Percent_Identity=32.5268817204301, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=30.6629834254144, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=30.6629834254144, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71982617, Length=292, Percent_Identity=30.4794520547945, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71982625, Length=292, Percent_Identity=30.4794520547945, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=30.9859154929577, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320438, Length=367, Percent_Identity=28.0653950953678, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=30.6049822064057, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24662918, Length=346, Percent_Identity=33.5260115606936, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17136286, Length=394, Percent_Identity=30.2030456852792, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17137420, Length=386, Percent_Identity=28.7564766839378, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=30.3249097472924, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=30.3249097472924, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=30.3249097472924, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41840; Mature: 41709

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLYDKYARLAGERLQFSDNGLTPFGTCIDEVYSATEGRIGNKKVILAGTNNYLGLTFNH
CCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECC
DAIREGQAALAAQGTGTTGSRMANGSYAPHLALEKEIAEFFNRPTAIVFSTGYTANLGVI
HHHHCCCHHEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
STLADHNAVVLLDADSHASIYDACSLGGAEIIRFRHNDVNDLERRMVRLGERAKEAIIIV
HHHCCCCEEEEEECCCCCCHHHHHCCCCHHEEEECCCCHHHHHHHHHHHHHHHHHEEEEH
EGIYSMLGDVAPLAEIVDIKRRLGGYLIVDEAHSFGVLGATGRGLAEAVGVEDDVDIIVG
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEECCCCCCHHHHCCCCCCCCEEEE
TFSKSLASIGGFAVGSEAMEVLRYGSRPYIFTASPSPSCIATVRSSLRTIASQPELRQKL
HHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHH
MDNANHLYDGLQKLGYELSSHISPVVPVIIGSKEEGLRIWRELISLGVYVNLILPPAAPA
HHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCCC
GITLLRCSVNAAHSREQIDAIIQAFATLKQ
CEEEEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLYDKYARLAGERLQFSDNGLTPFGTCIDEVYSATEGRIGNKKVILAGTNNYLGLTFNH
CCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECC
DAIREGQAALAAQGTGTTGSRMANGSYAPHLALEKEIAEFFNRPTAIVFSTGYTANLGVI
HHHHCCCHHEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
STLADHNAVVLLDADSHASIYDACSLGGAEIIRFRHNDVNDLERRMVRLGERAKEAIIIV
HHHCCCCEEEEEECCCCCCHHHHHCCCCHHEEEECCCCHHHHHHHHHHHHHHHHHEEEEH
EGIYSMLGDVAPLAEIVDIKRRLGGYLIVDEAHSFGVLGATGRGLAEAVGVEDDVDIIVG
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEECCCCCCHHHHCCCCCCCCEEEE
TFSKSLASIGGFAVGSEAMEVLRYGSRPYIFTASPSPSCIATVRSSLRTIASQPELRQKL
HHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHH
MDNANHLYDGLQKLGYELSSHISPVVPVIIGSKEEGLRIWRELISLGVYVNLILPPAAPA
HHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCCC
GITLLRCSVNAAHSREQIDAIIQAFATLKQ
CEEEEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]