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The map label for this gene is ireA [H]

Identifier: 218691198

GI number: 218691198

Start: 3476932

End: 3478980

Strand: Reverse

Name: ireA [H]

Synonym: ECED1_3551

Alternate gene names: 218691198

Gene position: 3478980-3476932 (Counterclockwise)

Preceding gene: 218691199

Following gene: 218691197

Centisome position: 66.78

GC content: 42.95

Gene sequence:

>2049_bases
ATGAAGACCAAAAGTATCATTGCTCCGGGCATTGCTGTGATATGTTCTACAGTCATATCATCAGGTTATGCCAGTTCTGA
TAAAAAAGAAGATACGCTTGTTGTTACTGCCTCCGGCTTCACTCAGCAACTCAGAAATGCACCGGCCAGTGTTTCAGTCA
TTACTTCAGAGCAACTGCAAAAAAAACCGGTTTCAGACCTGGTCGATGCGGTAAAAGATGTTGAAGGGATTAGTATCACC
GGTGGGAATGAAAAACCGGATATCAGTATACGTGGGTTAAGTGGCGATTATACATTGATTCTGGTCGATGGACGACGTCA
GAGTGGTCGGGAATCCAGACCAAACGGCAGCGGCGGTTTTGAAGCCGGATTTATCCCTCCTGTGGAAGCAATTGAGCGTA
TTGAAGTTATACGTGGCCCTATGTCTTCCCTGTATGGTTCCGATGCTATCGGAGGAGTTATTAATATCATAACCAAACCT
GTTAATAACCAGACATGGGATGGCGTACTTGGGCTTGGGGGAATTATTCAGGAACATGGGAAATTTGGTAACTCAACCAC
GAATGACTTCTACCTGTCAGGCCCATTGGTTAAGGATAAACTTGGTCTTCAGTTATATGGAGGAATGAACTATCGCAAGG
AAGATAGTATCTCTCAGGGAACACCAGCAAAAAATAATAAGAATATAACGGCAACACTCCAGTTTACTCCGACTGAAAGC
CAGAAGTTTGTTTTTGAATACGGAAAAAATAACCAGGAACATACATTAACACCTGGTGATTCTCTTGATGCCTGGACTAT
GCGGGGAAATCTTAAACAACCAAACAGTAAAAGAGAAACACATAACTCACGTAGTCACTGGGTAGCAGCATGGAATGCCC
AGGGCGAAATACTGCATCCTGAAATTGCTGTTTATCAGGAGAAAGTTATTCGTGAGGTTAAATCTGGTAAAAAAGATAAA
TATAATCATTGGGATCTTAATTACGAGTCAAGAAAACCGGAAATAACCAACACGATCATAGATGCAAAAGTGACGGCATT
TCTGCCGGAAAATGTGCTGACCATCGGAGGTCAATTTCAGCATGCAGAACTCCGTGATGACTCAGCCACAGGTAAAAAAA
CGACAGAAACACAGTCTGTTTCAGTTAAACAGAAAGCTGTTTTTATAGAAAATGAATATGCTGCAACGGATTCTCTCGCC
CTGACTGGAGGGCTGCGCCTCGATAACCATGAAATCTATGGCAGTTACTGGAATCCAAGATTGTATGCTGTTTATAACCT
GACCGATAATCTCACTCTCAAAGGAGGGATCGCAAAAGCATTTCGGGCCCCTTCGATTCGTGAGGTCAGTCCTGGATTTG
GAACACTGACGCAGGGTGGTGCCTCTATTATGTATGGAAACAGGGACCTGAAACCGGAGACCAGTGTAACCGAAGAGATC
GGTATTATTTATAATAATGACAGTGGTTTTTCAGCAAGCGCGACTCTGTTTAATACAGATTTTAAAAATAAGCTGACCAG
TTACGATATAGGCACAAAAGATCCAGTCACTGGGCTAAACACTTTTATTTATGATAATGTGGGTGAGGCAAATATCAGAG
GTGTGGAGCTTGCAACTCAGATTCCTGTGTATGATAAATGGCGTGTATCTGCAAACTATACATTCACTGACTCCCGTCGA
GAAAGCGATGACGAAAGTCTCAATGGCAAGTCGCTGAAAGGGGAACCTCTGGAAAGAACTCCCAGACATGCAGCCAATGC
AAAACTGGAATGGGATTACACTCAGGATATTACATTTTATTCATCTCTGAATTATACAGGAAAACAAATCTGGGCAGCAC
AAAGAAATGGTGCCAAGGTTCCCCGTGTTCGTAATGGATTCACTTCTATGGATATTGGTATGAATTACCAGTTCCTGCCA
GGCACGCTGATTAATTTTGCCGTACTTAACGTCACAGACAGAAAGAGCGAAGATATCGATACCATTGATGGTAACTGGCA
GGTCGATGAAGGACGTCGTTACTGGGCTAATGTGAGAATATCCTTCTGA

Upstream 100 bases:

>100_bases
CTGAGTGGGCTAAATGTGATTTACCTTCCTTTCAGTTCATTGTAAATTTCCTTATGCTAACGCAAATCATTATCATTACG
GTTTTGGTAGAAGGAAAGTT

Downstream 100 bases:

>100_bases
GAATGAAGTCAGAACCACCTGCATAGCGGGTGGTTTTACTTCTGTGTGGTATCGTTTTTCATATCGAGGGGGGCCTCCAG
AGATGAATGGAATAATAATA

Product: putative iron-regulated outer membrane virulence protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MKTKSIIAPGIAVICSTVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGISIT
GGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGFEAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKP
VNNQTWDGVLGLGGIIQEHGKFGNSTTNDFYLSGPLVKDKLGLQLYGGMNYRKEDSISQGTPAKNNKNITATLQFTPTES
QKFVFEYGKNNQEHTLTPGDSLDAWTMRGNLKQPNSKRETHNSRSHWVAAWNAQGEILHPEIAVYQEKVIREVKSGKKDK
YNHWDLNYESRKPEITNTIIDAKVTAFLPENVLTIGGQFQHAELRDDSATGKKTTETQSVSVKQKAVFIENEYAATDSLA
LTGGLRLDNHEIYGSYWNPRLYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEI
GIIYNNDSGFSASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQIPVYDKWRVSANYTFTDSRR
ESDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFYSSLNYTGKQIWAAQRNGAKVPRVRNGFTSMDIGMNYQFLP
GTLINFAVLNVTDRKSEDIDTIDGNWQVDEGRRYWANVRISF

Sequences:

>Translated_682_residues
MKTKSIIAPGIAVICSTVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGISIT
GGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGFEAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKP
VNNQTWDGVLGLGGIIQEHGKFGNSTTNDFYLSGPLVKDKLGLQLYGGMNYRKEDSISQGTPAKNNKNITATLQFTPTES
QKFVFEYGKNNQEHTLTPGDSLDAWTMRGNLKQPNSKRETHNSRSHWVAAWNAQGEILHPEIAVYQEKVIREVKSGKKDK
YNHWDLNYESRKPEITNTIIDAKVTAFLPENVLTIGGQFQHAELRDDSATGKKTTETQSVSVKQKAVFIENEYAATDSLA
LTGGLRLDNHEIYGSYWNPRLYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEI
GIIYNNDSGFSASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQIPVYDKWRVSANYTFTDSRR
ESDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFYSSLNYTGKQIWAAQRNGAKVPRVRNGFTSMDIGMNYQFLP
GTLINFAVLNVTDRKSEDIDTIDGNWQVDEGRRYWANVRISF
>Mature_682_residues
MKTKSIIAPGIAVICSTVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGISIT
GGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGFEAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKP
VNNQTWDGVLGLGGIIQEHGKFGNSTTNDFYLSGPLVKDKLGLQLYGGMNYRKEDSISQGTPAKNNKNITATLQFTPTES
QKFVFEYGKNNQEHTLTPGDSLDAWTMRGNLKQPNSKRETHNSRSHWVAAWNAQGEILHPEIAVYQEKVIREVKSGKKDK
YNHWDLNYESRKPEITNTIIDAKVTAFLPENVLTIGGQFQHAELRDDSATGKKTTETQSVSVKQKAVFIENEYAATDSLA
LTGGLRLDNHEIYGSYWNPRLYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEI
GIIYNNDSGFSASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQIPVYDKWRVSANYTFTDSRR
ESDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFYSSLNYTGKQIWAAQRNGAKVPRVRNGFTSMDIGMNYQFLP
GTLINFAVLNVTDRKSEDIDTIDGNWQVDEGRRYWANVRISF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=706, Percent_Identity=35.5524079320113, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786798, Length=647, Percent_Identity=28.7480680061824, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1790405, Length=151, Percent_Identity=35.7615894039735, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 75272; Mature: 75272

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKSIIAPGIAVICSTVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQ
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHCCCCEEEEEEHHHHH
KKPVSDLVDAVKDVEGISITGGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGF
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
EAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKPVNNQTWDGVLGLGGIIQEHG
CCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHC
KFGNSTTNDFYLSGPLVKDKLGLQLYGGMNYRKEDSISQGTPAKNNKNITATLQFTPTES
CCCCCCCCCEEEECCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
QKFVFEYGKNNQEHTLTPGDSLDAWTMRGNLKQPNSKRETHNSRSHWVAAWNAQGEILHP
CEEEEEECCCCCCCEECCCCCCCEEEEECCCCCCCCHHHCCCCCCCEEEEECCCCCEECC
EIAVYQEKVIREVKSGKKDKYNHWDLNYESRKPEITNTIIDAKVTAFLPENVLTIGGQFQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHEEECCEEEEECCCCEEEECCCEE
HAELRDDSATGKKTTETQSVSVKQKAVFIENEYAATDSLALTGGLRLDNHEIYGSYWNPR
ECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEECCEEECCCEEEEEECCCE
LYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEI
EEEEEECCCCEEECCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEE
GIIYNNDSGFSASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQ
EEEEECCCCCEEEEEEEECCHHHCCCCCCCCCCCCCCCCHHEEECCCCCCCCCEEEEEEE
IPVYDKWRVSANYTFTDSRRESDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFY
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEECCCCCEEEE
SSLNYTGKQIWAAQRNGAKVPRVRNGFTSMDIGMNYQFLPGTLINFAVLNVTDRKSEDID
EECCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCEEECCCCEEEEEEEEECCCCCCCCC
TIDGNWQVDEGRRYWANVRISF
CCCCCEEECCCCEEEEEEEEEC
>Mature Secondary Structure
MKTKSIIAPGIAVICSTVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQ
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHCCCCEEEEEEHHHHH
KKPVSDLVDAVKDVEGISITGGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGF
CCCHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
EAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKPVNNQTWDGVLGLGGIIQEHG
CCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHC
KFGNSTTNDFYLSGPLVKDKLGLQLYGGMNYRKEDSISQGTPAKNNKNITATLQFTPTES
CCCCCCCCCEEEECCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
QKFVFEYGKNNQEHTLTPGDSLDAWTMRGNLKQPNSKRETHNSRSHWVAAWNAQGEILHP
CEEEEEECCCCCCCEECCCCCCCEEEEECCCCCCCCHHHCCCCCCCEEEEECCCCCEECC
EIAVYQEKVIREVKSGKKDKYNHWDLNYESRKPEITNTIIDAKVTAFLPENVLTIGGQFQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHEEECCEEEEECCCCEEEECCCEE
HAELRDDSATGKKTTETQSVSVKQKAVFIENEYAATDSLALTGGLRLDNHEIYGSYWNPR
ECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEECCEEECCCEEEEEECCCE
LYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEI
EEEEEECCCCEEECCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEE
GIIYNNDSGFSASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQ
EEEEECCCCCEEEEEEEECCHHHCCCCCCCCCCCCCCCCHHEEECCCCCCCCCEEEEEEE
IPVYDKWRVSANYTFTDSRRESDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFY
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEECCCCCEEEE
SSLNYTGKQIWAAQRNGAKVPRVRNGFTSMDIGMNYQFLPGTLINFAVLNVTDRKSEDID
EECCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCEEECCCCEEEEEEEEECCCCCCCCC
TIDGNWQVDEGRRYWANVRISF
CCCCCEEECCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]