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The map label for this gene is serA [H]

Identifier: 218690938

GI number: 218690938

Start: 3205042

End: 3205998

Strand: Reverse

Name: serA [H]

Synonym: ECED1_3268

Alternate gene names: 218690938

Gene position: 3205998-3205042 (Counterclockwise)

Preceding gene: 218690939

Following gene: 218690937

Centisome position: 61.54

GC content: 44.31

Gene sequence:

>957_bases
GTGTCAGCTATGAAAAATGTTCTGGTCACCGTCCCCAGCTTTTCAGCACGCTGTGTTTCCGCCAGCAAGTTGCTAAGAGA
GAATAATTTTAATCTTATTATTAAGAATAATGTGGAGCATCTGCTTAAATCAGAATCCACTGCATTACGAGAATCTATTT
GCGCGGTCATCGCCGGAAAAGATTGTTATCAGGCGGACACGCTATCATTGCTGTCTGGTGTGAAAATAATATCGAGATTC
GGGACGGGGATAGACAATATTGATCTTCGTGCGGCACAGCAATCCGGTATTGTTGTCAATAATGCGGTTGGGATTAATTC
AAATGCGGTTGCGGAATTTATCATTGGACTTATCTTCGCGAGCATGAGAAATATCCCTGGCAGCTATCATGCGATGCAAA
ATGGCTACTGGGGGGAGTCGCATGGTTGTGAATTACAAGGGAAACGGATTGGCCTGGTTGGCTACGGTAATATAGGTAAA
ACTCTGGCGAAAAGGTTATCCGGTTTTGATGTTGAGCTTTTAGCTTTTGACAAACAACCCGACTATCAGGTTGCTGACAA
AGCTGGAGTTCAGTTTGTATCAATTGAAGATATCTTTATGCAGTCGCATGTCATCATTGTTCTTTTGCCTTTTTCTTCTG
AGCTGGAGAACTTCATTAGTCATAAATATTTGTCGATGATGCGCAATGGTGCTCTGATCATCAATGCCGCAAGGGGAAAG
TTGCTGGATGAGGGCGCTTTACTTCAGGTGATTGAAGAACGAAATGTGTTTGCGGCGCTGGATGTGTTTAGCTCTGAACC
GTTGGCGCAATTTAGCCCACTGCTACATGCCAAAAATATCATTACAACGCCGCATATCGCGGCCGCCACCGTTGAGTCAT
ACCAGCAAACCGGGATACACGTTGCCCAGTCGATAATTGATTACTTCGCAGGAAGGGAGATAAAAAACGTGTTGTGA

Upstream 100 bases:

>100_bases
ATCCAGGAGGTGCACTCGGCATTAAAGCAAATTCATAATTTCAAAATATAAATACAGTAACCGGTCACGCCATCTTTTGG
GGTGGCGTTCTTTGAAGTGA

Downstream 100 bases:

>100_bases
GTTCAGCGAACAAAGATTTTAAATACAAAAAAACCGCAATTTGTAGAACACATTGCGGTTTGTCAGCATTCTAATAAATT
GGTTGCGGGGGCCGGATTTG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSAMKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCYQADTLSLLSGVKIISRF
GTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGK
TLAKRLSGFDVELLAFDKQPDYQVADKAGVQFVSIEDIFMQSHVIIVLLPFSSELENFISHKYLSMMRNGALIINAARGK
LLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGIHVAQSIIDYFAGREIKNVL

Sequences:

>Translated_318_residues
MSAMKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCYQADTLSLLSGVKIISRF
GTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGK
TLAKRLSGFDVELLAFDKQPDYQVADKAGVQFVSIEDIFMQSHVIIVLLPFSSELENFISHKYLSMMRNGALIINAARGK
LLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGIHVAQSIIDYFAGREIKNVL
>Mature_317_residues
SAMKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCYQADTLSLLSGVKIISRFG
TGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKT
LAKRLSGFDVELLAFDKQPDYQVADKAGVQFVSIEDIFMQSHVIIVLLPFSSELENFISHKYLSMMRNGALIINAARGKL
LDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGIHVAQSIIDYFAGREIKNVL

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=300, Percent_Identity=30.6666666666667, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=29.5620437956204, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI145580578, Length=251, Percent_Identity=30.2788844621514, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4557499, Length=251, Percent_Identity=30.2788844621514, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI61743967, Length=277, Percent_Identity=28.8808664259928, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4557497, Length=277, Percent_Identity=28.8808664259928, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=31.7991631799163, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=26.7441860465116, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1787645, Length=197, Percent_Identity=30.9644670050761, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081824, Length=239, Percent_Identity=27.6150627615063, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=29.3375394321767, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=281, Percent_Identity=28.1138790035587, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=244, Percent_Identity=29.9180327868852, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=248, Percent_Identity=29.4354838709677, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=27.0042194092827, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=268, Percent_Identity=23.8805970149254, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=160, Percent_Identity=28.125, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=248, Percent_Identity=31.8548387096774, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585516, Length=323, Percent_Identity=26.625386996904, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=24.9134948096886, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585514, Length=329, Percent_Identity=25.531914893617, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28574282, Length=329, Percent_Identity=25.531914893617, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=25.3012048192771, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551003, Length=329, Percent_Identity=25.531914893617, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574284, Length=329, Percent_Identity=25.531914893617, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646446, Length=274, Percent_Identity=29.1970802919708, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=274, Percent_Identity=29.1970802919708, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=274, Percent_Identity=29.1970802919708, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=274, Percent_Identity=29.1970802919708, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571528, Length=327, Percent_Identity=25.6880733944954, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=29.1970802919708, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34646; Mature: 34515

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGK
CCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHCCC
DCYQADTLSLLSGVKIISRFGTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFA
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHH
SMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLAKRLSGFDVELLAFDKQP
HHHCCCCHHHHHCCCCCCCCCCCEECCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCC
DYQVADKAGVQFVSIEDIFMQSHVIIVLLPFSSELENFISHKYLSMMRNGALIINAARGK
CCCHHHHCCEEEEEHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
LLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGIH
CCCCCHHHHHHHHCCEEEEEEHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VAQSIIDYFAGREIKNVL
HHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
SAMKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGK
CCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHCCC
DCYQADTLSLLSGVKIISRFGTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFA
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHH
SMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLAKRLSGFDVELLAFDKQP
HHHCCCCHHHHHCCCCCCCCCCCEECCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCC
DYQVADKAGVQFVSIEDIFMQSHVIIVLLPFSSELENFISHKYLSMMRNGALIINAARGK
CCCHHHHCCEEEEEHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
LLDEGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGIH
CCCCCHHHHHHHHCCEEEEEEHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VAQSIIDYFAGREIKNVL
HHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]