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The map label for this gene is xapR [H]

Identifier: 218690542

GI number: 218690542

Start: 2795981

End: 2796865

Strand: Reverse

Name: xapR [H]

Synonym: ECED1_2848

Alternate gene names: 218690542

Gene position: 2796865-2795981 (Counterclockwise)

Preceding gene: 218690543

Following gene: 218690541

Centisome position: 53.69

GC content: 51.19

Gene sequence:

>885_bases
ATGGAACGCGTATATAGAACAGATCTTAAGTTGCTCCGTTATTTTCTTGCCGTAGCGGAAGAGTTGCATTTTGGTCGCGC
AGCAGCGCGTTTAAATATGTCTCAGCCTCCGCTCAGTATTCATATTAAAGAGCTGGAAAATCAACTCGGCACGCAGCTTT
TTATTCGCCATTCGCGCAGCGTCGTACTGACACACGCGGGCAAAATCTTGATGGAAGAATCGCGTCGATTGCTGGTGAAT
GCAAATAATGTATTGGCTCGGGTTGAACAAATAGGTCGGGGAGAAGCAGGGCGGATTGAACTCGGGGTTGTGGGAACGGC
AATGTGGGGACGGATGCGCCCGGTTATGCGGCGATTCCTTAGAGAAAATCCTAACGTTGAAGTTCTGTTTCGCGAAAAGA
TGCCTGCGATGCAAATGGCCTTGCTGGAACGCCGCGAACTTGATGCCGGGATCTGGCGAATGGCGACAGAACCACCGACT
GGTTTTACCAGCTTACGGTTGCATGAATCGGCGTTTCTGGTGGCGATGCCTGAAGAGCATCATCTCTCATCATTTTCCAC
CGTCCCGCTGGAAGCGCTACGTGACGAGTATTTCGTTACAATGCCGCCCGTGTACACTGACTGGGATTTTTTGCAGCGAG
TTTGCCAGCAGGTGGGATTTTCACCGGTTGTTATTCGCGAAGTTAATGAACCGCAAACGGTACTCGCCATGGTCAGTATG
GGTATTGGTATCACATTGATAGCGGACAGCTACGCGCAGATGAACTGGCCCGGTGTCATATTCCGTCCGCTCAAAGAACG
CATCCCGGCAGACTTATATATTGTTTATGAAACGCAGCAGGTGACGCCCGCGCTGGTTAAACTGCTAGCGGCGTTGGCGC
AGTAG

Upstream 100 bases:

>100_bases
ATATTATCCATCGTGTTTATGTATGTCGGATATCTGGTGGTGAAATACTTTATGCCATGATAATTTAATACGATGTATTT
TTTATATGGAGCACTTAATT

Downstream 100 bases:

>100_bases
ATGAGAGGCACGGGAACTGCCGGACATAGTTGGTCTGATAAGCGAAGCGCATCAGGCAATTTCGCAAATTGCAGATAGCA
AAAAAGCGCCTTTAGGGCGC

Product: DNA-binding transcriptional activator XapR

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MERVYRTDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELENQLGTQLFIRHSRSVVLTHAGKILMEESRRLLVN
ANNVLARVEQIGRGEAGRIELGVVGTAMWGRMRPVMRRFLRENPNVEVLFREKMPAMQMALLERRELDAGIWRMATEPPT
GFTSLRLHESAFLVAMPEEHHLSSFSTVPLEALRDEYFVTMPPVYTDWDFLQRVCQQVGFSPVVIREVNEPQTVLAMVSM
GIGITLIADSYAQMNWPGVIFRPLKERIPADLYIVYETQQVTPALVKLLAALAQ

Sequences:

>Translated_294_residues
MERVYRTDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELENQLGTQLFIRHSRSVVLTHAGKILMEESRRLLVN
ANNVLARVEQIGRGEAGRIELGVVGTAMWGRMRPVMRRFLRENPNVEVLFREKMPAMQMALLERRELDAGIWRMATEPPT
GFTSLRLHESAFLVAMPEEHHLSSFSTVPLEALRDEYFVTMPPVYTDWDFLQRVCQQVGFSPVVIREVNEPQTVLAMVSM
GIGITLIADSYAQMNWPGVIFRPLKERIPADLYIVYETQQVTPALVKLLAALAQ
>Mature_294_residues
MERVYRTDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELENQLGTQLFIRHSRSVVLTHAGKILMEESRRLLVN
ANNVLARVEQIGRGEAGRIELGVVGTAMWGRMRPVMRRFLRENPNVEVLFREKMPAMQMALLERRELDAGIWRMATEPPT
GFTSLRLHESAFLVAMPEEHHLSSFSTVPLEALRDEYFVTMPPVYTDWDFLQRVCQQVGFSPVVIREVNEPQTVLAMVSM
GIGITLIADSYAQMNWPGVIFRPLKERIPADLYIVYETQQVTPALVKLLAALAQ

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=294, Percent_Identity=98.2993197278912, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI1787879, Length=262, Percent_Identity=37.0229007633588, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788887, Length=286, Percent_Identity=29.3706293706294, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI157672245, Length=227, Percent_Identity=30.3964757709251, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790399, Length=240, Percent_Identity=27.5, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=27.6859504132231, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=26.9076305220884, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=27.4590163934426, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787589, Length=123, Percent_Identity=34.9593495934959, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787601, Length=282, Percent_Identity=26.241134751773, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=26.3779527559055, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788296, Length=244, Percent_Identity=25, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994962, Length=178, Percent_Identity=30.3370786516854, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081904, Length=151, Percent_Identity=32.4503311258278, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33581; Mature: 33581

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERVYRTDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELENQLGTQLFIRHSRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCHHHEECCCCC
VVLTHAGKILMEESRRLLVNANNVLARVEQIGRGEAGRIELGVVGTAMWGRMRPVMRRFL
EEEEHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
RENPNVEVLFREKMPAMQMALLERRELDAGIWRMATEPPTGFTSLRLHESAFLVAMPEEH
HCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHEECCCCCCCCEEEEEECCEEEEECCCHH
HLSSFSTVPLEALRDEYFVTMPPVYTDWDFLQRVCQQVGFSPVVIREVNEPQTVLAMVSM
CCCCCCCCCHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHH
GIGITLIADSYAQMNWPGVIFRPLKERIPADLYIVYETQQVTPALVKLLAALAQ
CCCEEEEECCHHHCCCCCCEEHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MERVYRTDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELENQLGTQLFIRHSRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCHHHEECCCCC
VVLTHAGKILMEESRRLLVNANNVLARVEQIGRGEAGRIELGVVGTAMWGRMRPVMRRFL
EEEEHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
RENPNVEVLFREKMPAMQMALLERRELDAGIWRMATEPPTGFTSLRLHESAFLVAMPEEH
HCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHEECCCCCCCCEEEEEECCEEEEECCCHH
HLSSFSTVPLEALRDEYFVTMPPVYTDWDFLQRVCQQVGFSPVVIREVNEPQTVLAMVSM
CCCCCCCCCHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHH
GIGITLIADSYAQMNWPGVIFRPLKERIPADLYIVYETQQVTPALVKLLAALAQ
CCCEEEEECCHHHCCCCCCEEHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]