Click here to switch to the map view.

The map label for this gene is oxc [H]

Identifier: 218690516

GI number: 218690516

Start: 2764999

End: 2766693

Strand: Reverse

Name: oxc [H]

Synonym: ECED1_2820

Alternate gene names: 218690516

Gene position: 2766693-2764999 (Counterclockwise)

Preceding gene: 218690517

Following gene: 218690515

Centisome position: 53.11

GC content: 47.08

Gene sequence:

>1695_bases
ATGTCAGATCAACTTCAAATGACAGATGGTATGCATATCATCGTTGAAGCATTAAAACAGAATAATATTGACACTATTTA
TGGTGTTGTAGGTATTCCTGTGACGGATATGGCGCGCCATGCCCAGGCGGAAGGCATTCGTTATATTGGTTTTCGTCATG
AGCAGTCGGCAGGCTATGCCGCTGCAGCAAGCGGTTTTCTTACCCAAAAACCAGGGATCTGCCTGACAGTGTCTGCGCCA
GGATTCCTCAATGGTTTGACCGCATTGGCCAATGCAACGGTAAATGGTTTTCCGATGATCATGATTAGCGGTTCCAGCGA
CCGCGCGATCGTCGATCTCCAGCAAGGTGATTATGAAGAGCTGGACCAAATGAATGCGGCAAAACCGTATGCCAAAGCAG
CATTTCGCGTTAATCAGCCGCAGGATCTTGGCATTGCATTGGCACGCGCTATCCGGGTCTCAGTATCGGGTCGTCCTGGC
GGTGTTTATCTTGATTTGCCAGCAAATGTCCTGGCCGCGACGATGGAAAAAGACGAAGCGTTAACCACGATTGTTAAAGT
TGAAAATCCGTCGCCAGCATTATTGCCATGCCCGAAGTCAGTCACTAGCGCAATTTCGCTTTTAGCAAAAGCTGAACGAC
CATTAATTATCCTTGGCAAAGGCGCGGCGTATTCACAATCTGATGAACAGCTTCGTGAATTTATTGAAAGTGCCCAGATT
CCATTCCTGCCAATGTCTATGGCGAAAGGGATCCTCGAAGATACGCATCCACTCTCTGCGGCAGCTGCGCGTTCGTTTGC
CCTGGCAAATGCTGACGTTGTCATGCTTGTTGGTGCACGACTGAATTGGTTACTGGCACACGGTAAAAAAGGATGGGCGG
CAGAAACACAGTTTATTCAACTGGATATTGAACCGCAGGAAATTGACAGCAACCGCCCCATTGCTGTGCCAGTCGTTGGC
GATATTGCATCCAGTATGCAAGGTATGTTGGCAGAATTGAAACAAAACACATTCACGACTCCACTGGTGTGGCGCGATAT
TTTAAATATCCACAAGCAGCAAAATGCACAAAAAATGCATGAAAAGTTAAGTACAGATACCCAACCATTAAATTACTTTA
ATGCATTGAGTGCTGTGCGCGATGTTTTGCGCGAGAACCAGGATATTTATTTAGTTAATGAAGGGGCAAATACCCTGGAT
AATGCACGAAATATTATTGATATGTATAAACCACGTCGTCGTCTGGATTGTGGCACCTGGGGTGTCATGGGCATCGGTAT
GGGCTATGCCATCGGTGCTAGCGTGACCTCTGGTTCTCCGGTTGTCGCCATTGAAGGTGATAGTGCTTTTGGTTTCAGTG
GGATGGAGATTGAAACGATTTGTCGATATAACCTGCCGGTGACGATCGTTATTTTTAATAATGGCGGCATCTACAGAGGT
GACGGTGTTGATCTCAGCGGCGCTGGTGCACCATCGCCAACGGATCTGTTGCACCATGCAAGGTATGACAAATTAATGGA
TGCGTTTCGTGGCGTTGGCTATAACGTCACCACGACAGATGAACTTCGTCATGCTTTAACCACCGGAATTCAGTCGCGCA
AACCGACCATTATTAATGTGGTCATCGACCCAGCAGCAGGAACTGAAAGTGGCCATATTACCAAACTTAACCCAAAACAA
GTCGCTGGTAATTAA

Upstream 100 bases:

>100_bases
ATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGATATTAACGGGGGCTTCTGGCTCCCAATTTATAA
AAATTTCGAGGTTATTAATC

Downstream 100 bases:

>100_bases
ATACTGACATCGTCTCCTCTTGCCAACTTATTATGCGATGGTAAGGGGACCCTTATCGGAAATACTATTATGCTAACATT
TTTTATTGGCGATTTATTGC

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAP
GFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPG
GVYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQSDEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAAETQFIQLDIEPQEIDSNRPIAVPVVG
DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLD
NARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQ
VAGN

Sequences:

>Translated_564_residues
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAP
GFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPG
GVYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQSDEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAAETQFIQLDIEPQEIDSNRPIAVPVVG
DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLD
NARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQ
VAGN
>Mature_563_residues
SDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAPG
FLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGG
VYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQSDEQLREFIESAQIP
FLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAAETQFIQLDIEPQEIDSNRPIAVPVVGD
IASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDN
ARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRGD
GVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQV
AGN

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=38.7096774193548, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI21361361, Length=511, Percent_Identity=26.614481409002, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788716, Length=564, Percent_Identity=99.645390070922, Blast_Score=1159, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=556, Percent_Identity=24.6402877697842, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1790104, Length=477, Percent_Identity=26.6247379454927, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786717, Length=478, Percent_Identity=26.3598326359833, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787096, Length=540, Percent_Identity=22.2222222222222, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531301, Length=549, Percent_Identity=37.8870673952641, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17531299, Length=549, Percent_Identity=37.8870673952641, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17542570, Length=514, Percent_Identity=27.2373540856031, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320816, Length=548, Percent_Identity=35.4014598540146, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6323755, Length=583, Percent_Identity=24.0137221269297, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=39.3939393939394, Blast_Score=395, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 60612; Mature: 60481

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
CCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCH
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
HHHCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHH
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
HHHCCCCCCHHHHHEECCCCHHHHHHHHHEEEEEECCCCCCEEEECCHHHHHHHHHHCCC
LTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQSDEQLREFIESAQI
EEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCC
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAAETQFIQ
CEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEE
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EECCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCC
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
CHHHHCCCHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEC
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
VIDPAAGTESGHITKLNPKQVAGN
EEECCCCCCCCCEEECCHHHCCCC
>Mature Secondary Structure 
SDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
CCCEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCH
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
HHHCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHH
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
HHHCCCCCCHHHHHEECCCCHHHHHHHHHEEEEEECCCCCCEEEECCHHHHHHHHHHCCC
LTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQSDEQLREFIESAQI
EEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCC
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAAETQFIQ
CEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEE
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EECCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCC
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
CHHHHCCCHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEC
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
VIDPAAGTESGHITKLNPKQVAGN
EEECCCCCCCCCEEECCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]