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The map label for this gene is dsdC [H]

Identifier: 218690507

GI number: 218690507

Start: 2751437

End: 2752372

Strand: Reverse

Name: dsdC [H]

Synonym: ECED1_2811

Alternate gene names: 218690507

Gene position: 2752372-2751437 (Counterclockwise)

Preceding gene: 218690510

Following gene: 218690505

Centisome position: 52.83

GC content: 48.08

Gene sequence:

>936_bases
ATGGAACCCCTTCGTGAAATAAGAAATCGACTGCTTAACGGCTGGCAACTATCAAAACTGCATACTTTTGAAGTGGCTGC
CAGGCATCAGTCCTTCGCCCTGGCGGCAGAGGAATTGTCGCTGAGCCCCAGTGCGGTAAGTCACCGTATCAATCAGCTGG
AAGAAGAATTAGGTATTCAGTTGTTTGTTCGTTCCCATCGCAAAGTGGAATTAACGCACGAGGGGAAACGTGTTTATTGG
GCGCTAAAATCGTCGCTGGATACCCTGAATCAGGAAATTCTGGATATCAAAAATCAGGAGTTATCGGGAACGTTAACTCT
GTATTCCCGGCCCTCTATCGCCCAATGCTGGTTGGTGCCCGCATTAGGTGACTTTACACGCCGATATCCGTCTATTTCGC
TCACCGTGCTCACTGGTAATGACAATGTCAATTTGCAACGTGCCGGAATCGATTTGGCGATCTACTTTGATGATGCGCCG
TCAGCGCAATTGGCTCATCACTTTCTGATGGATGAAGAAATCTTGCCAGTTTGCAGCCCGGAGTACGCTCAAAGACATGA
TTTAACCAACACGGTAATTAACCTGCGTCACTGTACGTTGCTCCATGACAGACAGGCATGGAGCAACGACTCCGGTACGG
ATGAATGGCATAGTTGGGCGCAACATTATGCGGCTAATTTGCCGACATCTTCTGGAATTGGCTTTGATCGTTCTGATTTA
GCCGTTATCGCCGCGATGAATCATGTTGGGGTGGCGATGGGAAGGAAACGCCTGGTACAAAAAAGGCTTGCTAGTGGTGA
GCTCGTCGCGCCGTTTGGCGATATGACGGTGAAATGCCATCAGCATTATTACATCACCACATTACCGGGCAGGCAGTGGC
CAAAAATTGAGGCATTTATTACTTGGTTAAGAGAACAGGTAAAAACCACTTCATAA

Upstream 100 bases:

>100_bases
CTAAAAATGAAGGTGAATTGAGATATGGTTCACTTTAGCTCACCTTACAGCTGAAATTTTGCCGCTATTTTTTTACACTT
AAGAGAAAAATGAGGTGATT

Downstream 100 bases:

>100_bases
TGAATAAGACCACGAGTTCCTGGTGTGCCTTATTCGGCACTGCTAGTGCGAATTTAATAATTTACGGTTTTTACGTGGTT
TTAGGGATAAACACAATAAT

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLAHHFLMDEEILPVCSPEYAQRHDLTNTVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAANLPTSSGIGFDRSDL
AVIAAMNHVGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVKTTS

Sequences:

>Translated_311_residues
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLAHHFLMDEEILPVCSPEYAQRHDLTNTVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAANLPTSSGIGFDRSDL
AVIAAMNHVGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVKTTS
>Mature_311_residues
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLAHHFLMDEEILPVCSPEYAQRHDLTNTVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAANLPTSSGIGFDRSDL
AVIAAMNHVGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVKTTS

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=311, Percent_Identity=97.7491961414791, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1786448, Length=296, Percent_Identity=33.445945945946, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=31.5972222222222, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786401, Length=298, Percent_Identity=26.1744966442953, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787128, Length=307, Percent_Identity=27.0358306188925, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI145693105, Length=168, Percent_Identity=27.3809523809524, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081978, Length=193, Percent_Identity=31.0880829015544, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789440, Length=269, Percent_Identity=26.3940520446097, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693193, Length=176, Percent_Identity=30.6818181818182, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788748, Length=169, Percent_Identity=28.4023668639053, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787589, Length=187, Percent_Identity=29.9465240641711, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790208, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082132, Length=284, Percent_Identity=25, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=172, Percent_Identity=33.1395348837209, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789639, Length=141, Percent_Identity=29.0780141843972, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=129, Percent_Identity=29.4573643410853, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35328; Mature: 35328

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
CCHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCE
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
EEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEEEH
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLAHHFLMDEEILPVCSP
HHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
EYAQRHDLTNTVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAANLPTSSGIGFDRSDL
HHHHHHCHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
AVIAAMNHVGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHHHH
TWLREQVKTTS
HHHHHHHHCCC
>Mature Secondary Structure
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
CCHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCE
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
EEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEEEH
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLAHHFLMDEEILPVCSP
HHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
EYAQRHDLTNTVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAANLPTSSGIGFDRSDL
HHHHHHCHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
AVIAAMNHVGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHHHH
TWLREQVKTTS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]