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The map label for this gene is pmrD [H]

Identifier: 218690423

GI number: 218690423

Start: 2663405

End: 2663671

Strand: Reverse

Name: pmrD [H]

Synonym: ECED1_2727

Alternate gene names: 218690423

Gene position: 2663671-2663405 (Counterclockwise)

Preceding gene: 218690424

Following gene: 218690415

Centisome position: 51.13

GC content: 46.44

Gene sequence:

>267_bases
ATGGAATGGCTGGTCAAAAAAACGTGCTGCAATAAACAAGATAACAGACATGTAATTATGCTCTGCGATGCTGGCGGCGC
GATAAAAATGATCGCCGAAGTGAAGAGTGACTTCGCCGTGAAAGTGGGGGATTTACTCTCGCCTTTGCAGAATGCGCTTT
ACTGTATTAATCGTGAAAAGCTGCACACGGTGAAAGTTCTTTCTGCAAGCTGTTATAGCCCCGATGAGTGGGAACGGCAG
TGTAAAGCGGCAGGGAAAACTCAGTAA

Upstream 100 bases:

>100_bases
CGTTTCACTTCTCATTTCTGCCATTCCATTGCCGTTGATAAAGAGTTTATCTGTTAATCTGTAAATTGATGTGAAAACTC
TTAGCAAACAGGATAATGCA

Downstream 100 bases:

>100_bases
CGTTGTTTTGTTGTGGGCAGGAAAATCAGCATCAACCCGCTCATAATACAGGCTACTCCCAGTAGTGCTTTCAGCGAAAA
AGTCCCTTCCCAGCCGGGAA

Product: polymyxin resistance protein B

Products: NA

Alternate protein names: BasR post-transcriptional activator; Polymyxin resistance protein pmrD [H]

Number of amino acids: Translated: 88; Mature: 88

Protein sequence:

>88_residues
MEWLVKKTCCNKQDNRHVIMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASCYSPDEWERQ
CKAAGKTQ

Sequences:

>Translated_88_residues
MEWLVKKTCCNKQDNRHVIMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASCYSPDEWERQ
CKAAGKTQ
>Mature_88_residues
MEWLVKKTCCNKQDNRHVIMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASCYSPDEWERQ
CKAAGKTQ

Specific function: Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pmrD family [H]

Homologues:

Organism=Escherichia coli, GI87082076, Length=88, Percent_Identity=95.4545454545455, Blast_Score=178, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020146
- ProDom:   PD028730 [H]

Pfam domain/function: PF11183 PmrD [H]

EC number: NA

Molecular weight: Translated: 9873; Mature: 9873

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
10.2 %Cys+Met (Translated Protein)
6.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
10.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWLVKKTCCNKQDNRHVIMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREK
CCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCH
LHTVKVLSASCYSPDEWERQCKAAGKTQ
HHHHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MEWLVKKTCCNKQDNRHVIMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREK
CCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCH
LHTVKVLSASCYSPDEWERQCKAAGKTQ
HHHHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626063; 9205837; 9278503 [H]