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The map label for this gene is irp [H]

Identifier: 218689971

GI number: 218689971

Start: 2165774

End: 2167078

Strand: Reverse

Name: irp [H]

Synonym: ECED1_2244

Alternate gene names: 218689971

Gene position: 2167078-2165774 (Counterclockwise)

Preceding gene: 218689972

Following gene: 218689962

Centisome position: 41.6

GC content: 55.33

Gene sequence:

>1305_bases
ATGAAAATCAGTGAATTTTTACACCTGGCGTTACCAGAGGAACAATGGCTGCCGACGATTTCTGGCGTTTTACGCCAGTT
CGCAGAAGAAGAGTGTTATGTCTATGAGCGTCAACCCTGTTGGTATTTAGGCAAAGGGTGCCTGGCACGGTTGCACATTA
ATGCCGACGGAACGCAGGCGACATTTATTGATGATGCCGGGGAGCAACAATGGGCGGTGGATTCCATTACCGACTGCGCG
CGTCGTTTTATGGCACATCCTCAGGTGAAAGGACGTCGGGTTTATGGACAGGTTGGGTTCAACTTTGCGGCGCATGCGCG
GGGGATTGCCTTTAACGCCGGGGAGTGGCCGCTGCTGACGTTAACCGTTCCCCGTGAAGAACTTATTTTTGAAAAGGGAA
ATGTCACCGTTTATGCGGACTCCGCCGACGGGGGCCGACGTTTGTGTGAGTGGGTAAAAGAGGCCAGTACAACGACGCAG
AACGCACCACTGGCGGTGGATACCGCCCTCAATGGCGAGGCGTATAAACAACAGGTTGCACGCGCCGTTGCGGAGATCCG
CCGTGGCGAGTATGTCAAAGTGATTGTCTCGCGCGCTATTCCCCTGCCATCGCGGATTGATATGCCCGCCACGCTGTTAT
ACGGGCGGCAGGCAAATACACCTGTGCGCTCGTTTATGTTCCGTCAGGAAGGACGCGAAGCGCTGGGCTTTAGCCCGGAA
CTGGTGATGTCAGTGACGGGCAATAAAGTGGTCACTGAACCGCTTGCGGGCACCCGCGATCGCATGGGAAACCCGGAGCA
TAATAAGGCGAAAGAGGCAGAACTGCTGCACGACAGTAAAGAGGTGCTTGAGCATATCCTTTCTGTCAAAGAAGCGATTG
CTGAACTGGAGGCCGTTTGCCTGCCGGGCAGCGTGGTGGTTGAAGATTTAATGTCGGTTCGCCAGCGCGGCAGCGTTCAG
CATCTGGGGTCCGGCGTGAGCGGTCAGCTTGCGGAAAACAAGGATGCCTGGGATGCGTTTACCGTGCTGTTTCCGTCGAT
TACCGCCTCAGGTATCCCTAAAAACGCTGCCCTGAACGCGATTATGCAAATTGAGAAGACGCCGCGAGAGCTCTATTCCG
GCGCAATTCTGCTGCTGGACGATATGCGCTTCGATGCGGCGCTAGTTCTGCGTTCCGTATTTCAGGACAGCCAGCGCTGC
TGGATACAAGCGGGGGCGGGAATCATCGCGCAATCTACACCGGAACGCGAACTGACGGAAACCCGGGAGAAATTAGCGAG
CATTGCGCCCTATTTAATGGTGTAG

Upstream 100 bases:

>100_bases
GTTGCTGGCGGCGTGGGTTGCTTATATCCGGCTGCATTCGGCAAGAGAACTGATGACAAGCGCAATTGATTGATCCGGGA
ATAACACAGAGAGGTAAGGG

Downstream 100 bases:

>100_bases
GAGTAACTGTTTTCTAACCTCACAACCAGACTGTCCAAAGACAATTGAGTCGCTCTTTGATTCCTCTGTGACTCTATTGT
CTTCTTTTTGGATAAAATAG

Product: salicylate synthase Irp9

Products: NA

Alternate protein names: Mycobactin synthase protein I; Salicylate synthase mbtI [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYERQPCWYLGKGCLARLHINADGTQATFIDDAGEQQWAVDSITDCA
RRFMAHPQVKGRRVYGQVGFNFAAHARGIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGGRRLCEWVKEASTTTQ
NAPLAVDTALNGEAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPE
LVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCLPGSVVVEDLMSVRQRGSVQ
HLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDMRFDAALVLRSVFQDSQRC
WIQAGAGIIAQSTPERELTETREKLASIAPYLMV

Sequences:

>Translated_434_residues
MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYERQPCWYLGKGCLARLHINADGTQATFIDDAGEQQWAVDSITDCA
RRFMAHPQVKGRRVYGQVGFNFAAHARGIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGGRRLCEWVKEASTTTQ
NAPLAVDTALNGEAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPE
LVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCLPGSVVVEDLMSVRQRGSVQ
HLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDMRFDAALVLRSVFQDSQRC
WIQAGAGIIAQSTPERELTETREKLASIAPYLMV
>Mature_434_residues
MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYERQPCWYLGKGCLARLHINADGTQATFIDDAGEQQWAVDSITDCA
RRFMAHPQVKGRRVYGQVGFNFAAHARGIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGGRRLCEWVKEASTTTQ
NAPLAVDTALNGEAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPE
LVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCLPGSVVVEDLMSVRQRGSVQ
HLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDMRFDAALVLRSVFQDSQRC
WIQAGAGIIAQSTPERELTETREKLASIAPYLMV

Specific function: Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicyl

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family. Salicylate synthase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=251, Percent_Identity=33.4661354581673, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788114, Length=262, Percent_Identity=25.9541984732824, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082077, Length=265, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786809, Length=266, Percent_Identity=27.8195488721804, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=256, Percent_Identity=30.078125, Blast_Score=117, Evalue=5e-27,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR015890
- InterPro:   IPR019996 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 48002; Mature: 48002

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYERQPCWYLGKGCLARLHINADGTQA
CCHHHHHHHCCCCHHCCHHHHHHHHHHCCCCCEEEECCCCCEECCCCEEEEEECCCCCEE
TFIDDAGEQQWAVDSITDCARRFMAHPQVKGRRVYGQVGFNFAAHARGIAFNAGEWPLLT
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCEEECCCCCEEEE
LTVPREELIFEKGNVTVYADSADGGRRLCEWVKEASTTTQNAPLAVDTALNGEAYKQQVA
EECCHHHHEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHH
RAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPE
HHHHHHHCCCCEEEHHHHCCCCCCCCCCCHHEEECCCCCCHHHHHHHHHCCHHHCCCCCC
LVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVC
EEEEECCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNA
CCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
IMQIEKTPRELYSGAILLLDDMRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELTE
HHHHHCCHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHEEHHCCCCEEECCCCCHHHHH
TREKLASIAPYLMV
HHHHHHHHCCHHCC
>Mature Secondary Structure
MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYERQPCWYLGKGCLARLHINADGTQA
CCHHHHHHHCCCCHHCCHHHHHHHHHHCCCCCEEEECCCCCEECCCCEEEEEECCCCCEE
TFIDDAGEQQWAVDSITDCARRFMAHPQVKGRRVYGQVGFNFAAHARGIAFNAGEWPLLT
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCCEEECCCCCEEEE
LTVPREELIFEKGNVTVYADSADGGRRLCEWVKEASTTTQNAPLAVDTALNGEAYKQQVA
EECCHHHHEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHH
RAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALGFSPE
HHHHHHHCCCCEEEHHHHCCCCCCCCCCCHHEEECCCCCCHHHHHHHHHCCHHHCCCCCC
LVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVC
EEEEECCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNA
CCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
IMQIEKTPRELYSGAILLLDDMRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELTE
HHHHHCCHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHEEHHCCCCEEECCCCCHHHHH
TREKLASIAPYLMV
HHHHHHHHCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA