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The map label for this gene is edd [H]

Identifier: 218689789

GI number: 218689789

Start: 2001978

End: 2003789

Strand: Reverse

Name: edd [H]

Synonym: ECED1_2056

Alternate gene names: 218689789

Gene position: 2003789-2001978 (Counterclockwise)

Preceding gene: 218689790

Following gene: 218689788

Centisome position: 38.46

GC content: 53.42

Gene sequence:

>1812_bases
ATGAATCCACAATTGTTACGCGTAACAAATCGAATCATTGAACGTTCGCGCGAGACTCGCTCTGCTTACCTCGCCCGGAT
AGAACAAGCGAAAACTTCGACCGTTCATCGTTCGCAGTTGGCATGCGGTAACCTGGCACACGGTTTCGCTGCCTGCCAGC
CAGAAGACAAAGCCTCTTTGAAAAGCATGTTGCGTAACAATATCGCCATCATCACCTCCTATAACGACATGCTCTCCGCT
CACCAGCCTTATGAACACTATCCGGAAATCATTCGTAAAGCCCTGCATGAAGCGAATGCGGTTGGTCAGGTTGCGGGCGG
TGTTCCGGCGATGTGTGATGGTGTCACCCAGGGGCAGGATGGAATGGAATTGTCGCTGTTAAGCCGCGAAGTGATTGCGA
TGTCTGCGGCGGTGGGGCTGTCCCATAACATGTTTGATGGTGCTCTGTTTCTCGGTGTGTGCGACAAGATTGTCCCAGGT
CTGACCATGGCAGCCCTGTCGTTTGGTCATTTGCCTGCGGTGTTTGTGCCGTCTGGACCGATGGCAAGCGGTTTGCCAAA
TAAAGAAAAAGTGCGTATTCGCCAGCTTTATGCCGAAGGTAAAGTGGACCGCATGGCATTACTGGAGTCAGAAGCCGCGT
CTTATCATGCGCCGGGAACATGTACTTTCTACGGTACTGCCAACACCAACCAGATGGTGGTGGAGTTTATGGGGATGCAG
TTGCCAGGCTCTTCTTTTGTTCATCCGGATTCTCCGCTGCGCGATGCTTTGACCGCTGCAGCTGCGCGCCAGGTTACGCG
CATGACCGGTAATGGTAATGAATGGATGCCGATCGGTAAGATGATCGATGAGAAAGTGGTGGTGAACGGTATCGTTGCAC
TGCTGGCGACCGGTGGCTCCACTAACCACACCATGCACCTGGTGGCGATGGCGCGCGCAGCCGGTATTCAGATTAACTGG
GATGACTTCTCTGACCTTTCTGATGTTGTACCGCTGATGGCACGTCTCTACCCGAACGGTCCGGCCGATATTAACCACTT
CCAGGCGGCAGGTGGCGTACCGGTTCTGGTACGTGAACTGCTCAAAGCAGGCCTGCTGCATGAAGATGTCAATACGGTGG
CAGGCTTTGGTCTGTCTCGTTATACCCTTGAACCATGGCTGAATAATGGTGAACTGGACTGGCGGGAAGGGGCAGAAAAA
TCACTCGACAACAATGTGATCGCGTCCTTCGAACAACCTTTCTCTCATCATGGTGGGACAAAAGTGTTAAGCGGTAACCT
GGGGCGAGCGGTTATGAAAACCTCTGCCGTGCCGGTAGAGAACCAGGTGATTGAAGCGCCAGCGGTTGTTTTTGAAAGCC
AGCATGACGTTATGCCGGCCTTTGAAGCGGGTTTACTGGACCGCGATTGTGTCGTTGTTGTCCGTCATCAGGGGCCAAAA
GCGAACGGAATGCCAGAATTACATAAACTCATGCCGCCACTTGGTGTATTATTGGACCGGTGTTTCAAAATTGCGTTAGT
TACCGATGGACGACTCTCCGGCGCTTCAGGTAAAGTGCCGTCAGCTATCCACGTAACACCAGAGGCCTACGATGGCGGGC
TGCTGGCAAAAGTGCGCGACGGGGACATCATTCGTGTGAATGGACAGACAGGCGAACTGACGCTGCTGGTAGACGAAGCG
GAACTGGCTGCTCGCGAACCGCACATTCCTGACCTGAGCGCGTCACGCGTGGGAACAGGACGTGAATTATTCAGCGCCTT
GCGTGAAAAACTGTCCGGTGCCGAACAGGGCGCAACCTGTATCACTTTTTAA

Upstream 100 bases:

>100_bases
TGCCCTATGAGCTCCGGTTACAGGCGTTTCAGTCATGAATCCTCTGAATGAAACGTGTTGTGAATCATCCTGCTCTGACA
ACTCAATTTCAGGAGCCTTT

Downstream 100 bases:

>100_bases
GACGACAAATTTGTAATCAGGCGAGAGAAAACTCTGATGAAAAACTGGAAAACAAGTGCAGAATCAATCCTGACCACCGG
CCCGGTTGTACCGGTTATCG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPG
LTMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINW
DDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVRELLKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEK
SLDNNVIASFEQPFSHHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATCITF

Sequences:

>Translated_603_residues
MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPG
LTMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINW
DDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVRELLKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEK
SLDNNVIASFEQPFSHHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATCITF
>Mature_603_residues
MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPG
LTMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINW
DDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVRELLKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEK
SLDNNVIASFEQPFSHHGGTKVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATCITF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=99.8341625207297, Blast_Score=1240, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=539, Percent_Identity=30.2411873840445, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI2367371, Length=478, Percent_Identity=30.3347280334728, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786464, Length=555, Percent_Identity=27.9279279279279, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6322476, Length=478, Percent_Identity=30.9623430962343, Blast_Score=179, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64667; Mature: 64667

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KSMLRNNIAIITSYNDMLSAHQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPGLTMAALSFGHLPAVFVPSGP
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGIQINWDDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVREL
CCCEEEEEEHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEKSLDNNVIASFEQPFSHHGGT
HHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCHHHHCCCCHHHHHHCCHHHCCCC
KVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPK
EEEECCCCHHHHHHCCCCCCHHHHHCCHHHCCCCCCCCCHHHHCCCCCCEEEEEECCCCC
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDIIRVNGQTGELTLLVDEAELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC
>Mature Secondary Structure
MNPQLLRVTNRIIERSRETRSAYLARIEQAKTSTVHRSQLACGNLAHGFAACQPEDKASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KSMLRNNIAIITSYNDMLSAHQPYEHYPEIIRKALHEANAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPGLTMAALSFGHLPAVFVPSGP
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDSPLRDALTAAAARQVTRMTGNGNEWMPIGKMIDEKVVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGIQINWDDFSDLSDVVPLMARLYPNGPADINHFQAAGGVPVLVREL
CCCEEEEEEHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LKAGLLHEDVNTVAGFGLSRYTLEPWLNNGELDWREGAEKSLDNNVIASFEQPFSHHGGT
HHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCHHHHCCCCHHHHHHCCHHHCCCC
KVLSGNLGRAVMKTSAVPVENQVIEAPAVVFESQHDVMPAFEAGLLDRDCVVVVRHQGPK
EEEECCCCHHHHHHCCCCCCHHHHHCCHHHCCCCCCCCCHHHHCCCCCCEEEEEECCCCC
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDIIRVNGQTGELTLLVDEAELAAREPHIPDLSASRVGTGRELFSALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]