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The map label for this gene is adrB [H]

Identifier: 218689751

GI number: 218689751

Start: 1967626

End: 1969224

Strand: Direct

Name: adrB [H]

Synonym: ECED1_2018

Alternate gene names: 218689751

Gene position: 1967626-1969224 (Clockwise)

Preceding gene: 218689750

Following gene: 218689753

Centisome position: 37.77

GC content: 49.91

Gene sequence:

>1599_bases
ATGCAAAAAGCACAACGGATCATTAAAACCTATCGCCGTAATCGAATGATTGTTTGTACGATTTGCGCACTCGTTACGCT
CGCTTCGACCCTGAGCGTGCGATTTATTTCACAGCGTAACTTAAATCAACAACGGGTAGTACAATTCGCCAATCACGCTG
TAGAGGAATTAGATAAAGTACTGCTTCCCCTACAGGCAGGTAGCGAAGTCTTGCTTCCGCTGATTGGTCTGCCCTGCTCT
GTCGCCCATTTGCCATTACGTAAACAGGCTGCAAAACTCCAAACTGTGCGATCCATTGGCTTGGTGCAAGACGGCACACT
TTATTGCTCCAGCATTTTTGGTTATCGCAATGTGCCCGTCGTGGACATTCTGGCTGAACTTCCTGCACCGCAACCACTTT
TACGACTGACGACCGACCGTGCCCTGATAAAAGGCAGTCCGGTTTTGATTCAATGGACGCCTGCAGCGGGCAGTAGCAAT
GCTGGGGTCATGGAGATGATTAACATCGACTTACTGACGGCAATGCTCCTTGAACCACAACTGCCGCAAATCAGTAGCGC
CAGCCTGACGGTGGACAGTCGGCATTTGCTCTATGGTAATGGGCTGGTAGATTCCCTTCCGCAACCTGAAAACAATGAAA
ACTATCAGGTTTCTTCGCAACGCTTTCCTTTTACCATTAACGTTAATGGCCCAGGGGCTACGGCGCTGGCATGGCACTAT
CTTCCAACACAATTACCGCTGGCGGTGCTGCTAAGTTTACTGGTGGGCTACATCGCCTGGCTGGCGACCGCTTACCGAAT
GAGCTTTTCCCGCGAGATCAATCTGGGCCTGGCGCAACATGAGTTCGAATTGTTCTGTCAGCCTTTGCTTAATGCGCGCA
GCCAGCAATGTATTGGTGTAGAGATTTTGCTGCGCTGGAACAATCCACGTCAGGGCTGGATTTCACCGGATGTGTTTATT
CCTATCGCGGAAGAACATCATTTAATTGTGCCACTAACCCGCTATGTGATGGCCGAAACCATTCGTCAGCGCCATGTTTT
CCCAATGAGTAGTCAGTTTCATGTTGGCATTAACGTCGCACCCAGCCATTTTCGCCGTGGTGTGCTGATAAAAGATCTCA
ATCAGTACTGGTTTAGCGCTCACCCGATTCAGCAACTGATCCTCGAAATCACCGAACGCGATGCCTTACTGGATGTTGAT
TACCGGATTGCCCGCGAGCTGCATCGTAAAAACGTCAAACTGGCGATTGATGACTTCGGCACCGGCAACAGTTCATTTTC
CTGGCTTGAAACATTACGTCCTGACGTTCTGAAAATTGATAAGTCATTTACCGCAGCTATAGGTTCTGATGCGGTTAACT
CGACGGTGACCGATATCATCATCGCACTGGGGCAAAGACTGAATATTGAACTGGTGGCGGAGGGCGTAGAAACGCAAGAA
CAGGCGAAGTATTTGCGCAGTCATGGCGTGCATATTTTGCAAGGGTATTTGTACGCACAGCCGATGCCGCTACGTGATTT
TCCCAAATGGCTGGCGGGCAGCCAACCGCCGCCCGCCCGGCATAATGGACATATCACACCCATTATGCCGTTACGTTAA

Upstream 100 bases:

>100_bases
GGCGAATTTATTCCCGCTTCCTCGTCTGCTGTAATTTTCCCCACTACACTTCCACTGTTGCGTCAGGCGTTTGTCGCCAT
ACGCTTACAGGGTGGCCCGC

Downstream 100 bases:

>100_bases
CGCTTACTCATCTTCATCGTGCGCCGGTTGCTCTTTAACAATGCGAACCAGATCAACACGATAATCATTGGCTTCAATGA
TGGTGATATGCAGTGGCCCT

Product: putative cyclic di-GMP phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSN
AGVMEMINIDLLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRSHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR

Sequences:

>Translated_532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSN
AGVMEMINIDLLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRSHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
>Mature_532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSN
AGVMEMINIDLLTAMLLEPQLPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRSHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=532, Percent_Identity=99.2481203007519, Blast_Score=1082, Evalue=0.0,
Organism=Escherichia coli, GI1788502, Length=527, Percent_Identity=29.6015180265655, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI87081845, Length=528, Percent_Identity=27.8409090909091, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1786507, Length=247, Percent_Identity=39.2712550607287, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1790496, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081921, Length=261, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081743, Length=327, Percent_Identity=31.1926605504587, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI226510982, Length=262, Percent_Identity=31.6793893129771, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787541, Length=259, Percent_Identity=30.5019305019305, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788849, Length=239, Percent_Identity=31.7991631799163, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082096, Length=242, Percent_Identity=29.7520661157025, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787055, Length=254, Percent_Identity=30.3149606299213, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 59589; Mature: 59589

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
LLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV
HHCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCH
VDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQ
HHHHHHCCCCCCHHHEECCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
LPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNGPGATALAWHY
CCCCCCCEEEECCCEEEEECCHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEC
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
EILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVA
EEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCC
TGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
CCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
QAKYLRSHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
HHHHHHHCCHHEEEHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
LLPLQAGSEVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV
HHCCCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCH
VDILAELPAPQPLLRLTTDRALIKGSPVLIQWTPAAGSSNAGVMEMINIDLLTAMLLEPQ
HHHHHHCCCCCCHHHEECCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
LPQISSASLTVDSRHLLYGNGLVDSLPQPENNENYQVSSQRFPFTINVNGPGATALAWHY
CCCCCCCEEEECCCEEEEECCHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEC
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
EILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMSSQFHVGINVA
EEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCC
TGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
CCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
QAKYLRSHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMPLR
HHHHHHHCCHHEEEHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]