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The map label for this gene is dmlR [H]

Identifier: 218689739

GI number: 218689739

Start: 1955647

End: 1955979

Strand: Reverse

Name: dmlR [H]

Synonym: ECED1_2005

Alternate gene names: 218689739

Gene position: 1955979-1955647 (Counterclockwise)

Preceding gene: 218689740

Following gene: 218689738

Centisome position: 37.55

GC content: 48.35

Gene sequence:

>333_bases
TTGAGCTTAACGCAAAATGCGCTCGACACCACGACGAGTAAATACCGATTCCTGAATGACGACTTCATTCTCTGTTCCTT
CATTTACTCTACCGCCTGGCGAGGAATATTCGCCTTCGGTGTTTTTCCGGACCACGTAAAAATCGATGTCGCCAGGCTGT
TTCCCGCCAGTGGTCATTTAGTACAAGTGCTACCGGAATATTACCAGCCAGCGAATGTCTGGGCCGTTTATGTTTCAAAG
CTGTCGACGTCAGCGAAAGTGCGGATAACGGTAGAATTTTTACGCCAGTATTTTGCCGAGCACTACCCGAATTTTTCACT
GGAGCAGGCCTGA

Upstream 100 bases:

>100_bases
AGGAATATCCACAGTAAAATCTTCCGAAGCCGGACTGGGCGCGCTCAGTCCGGCTTCGGCAAACTACAAATCCAACAGCA
GGCGGTTCAAATGAACTTAT

Downstream 100 bases:

>100_bases
TTAATGATTCAATTATCGGGTTGATATCGGGTTAAAACCTGATTTTCTCCTTTCTAAGCCGCTACAGATTGGTTAGCATA
TTCACCTTTAATCGCGCATG

Product: putative LuxR family transcription regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSLTQNALDTTTSKYRFLNDDFILCSFIYSTAWRGIFAFGVFPDHVKIDVARLFPASGHLVQVLPEYYQPANVWAVYVSK
LSTSAKVRITVEFLRQYFAEHYPNFSLEQA

Sequences:

>Translated_110_residues
MSLTQNALDTTTSKYRFLNDDFILCSFIYSTAWRGIFAFGVFPDHVKIDVARLFPASGHLVQVLPEYYQPANVWAVYVSK
LSTSAKVRITVEFLRQYFAEHYPNFSLEQA
>Mature_109_residues
SLTQNALDTTTSKYRFLNDDFILCSFIYSTAWRGIFAFGVFPDHVKIDVARLFPASGHLVQVLPEYYQPANVWAVYVSKL
STSAKVRITVEFLRQYFAEHYPNFSLEQA

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=55, Percent_Identity=94.5454545454545, Blast_Score=111, Evalue=8e-27,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 12681; Mature: 12549

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTQNALDTTTSKYRFLNDDFILCSFIYSTAWRGIFAFGVFPDHVKIDVARLFPASGHL
CCCCCCHHHCCCCCEEECCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEHHHHCCCCCCH
VQVLPEYYQPANVWAVYVSKLSTSAKVRITVEFLRQYFAEHYPNFSLEQA
HHHHHHHCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLTQNALDTTTSKYRFLNDDFILCSFIYSTAWRGIFAFGVFPDHVKIDVARLFPASGHL
CCCCCHHHCCCCCEEECCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEHHHHCCCCCCH
VQVLPEYYQPANVWAVYVSKLSTSAKVRITVEFLRQYFAEHYPNFSLEQA
HHHHHHHCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]