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The map label for this gene is yeaP [H]

Identifier: 218689734

GI number: 218689734

Start: 1952476

End: 1953501

Strand: Direct

Name: yeaP [H]

Synonym: ECED1_2000

Alternate gene names: 218689734

Gene position: 1952476-1953501 (Clockwise)

Preceding gene: 218689732

Following gene: 218689745

Centisome position: 37.48

GC content: 48.05

Gene sequence:

>1026_bases
GTGTCAGATCAGATTATCGCCCGCGTCTCGCAATCCCTTGCCAAAGAACAGTCACTGGAAAGTCTGGTTCGACAGCTTCT
GGAGATGCTGGAAATGGTCACTGATATGGAGTCAACCTACCTGACCAAAGTGGATGTCGAAGCGCGCCTGCAGCATATAA
TGTTTGCCCGTAATAGCCAGAAAATGCACATCCCGGAGAATTTTACCGTCTCGTGGGATTACTCGTTATGCAAACGCGCC
ATTGATGAAAACTGTTTTTTCAGCGATGAAGTCCCCGACCGTTGGGGCGACTGTGTTGCGGCACGCAATCTTGGCATCAC
CACATTTCTGAGCACGCCAATTCACTTACCGGATGGATCATTCTATGGCACGCTTTGCGCCGCCAGCAGTGAGAAGCGCC
AGTGGAGTGAACGCGCGGAACAGGTCTTACAGTTGTTCGCCGGACTGATTGCACAATATATTCAAAAAGAGGCACTGGTT
GAACAGCTGCGCGAAGCTAATGCTGCGCTGATTGCGCAATCGTATACCGACTCGTTAACCGGGCTACCGAATCGGCGGGC
GATTTTTGAAAATCTGACGACGCTGTTTTCTCTCGCCCGGCATCTTAACCATAAGATAATGATCGCGTTTATCGATCTGG
ATAACTTCAAATTAATCAATGATCGTTTTGGTCATAATAGTGGCGATCTGTTTCTCATTCAGGTTGGCGAGCGCCTTAAT
ACGCTCCAGCAAAATGGCGAAGTTATTGGTCGTCTCGGCGGTGATGAGTTTTTGGTTGTTTCACTGAACAACGAGAATGC
GGATATTTCGTCGCTGCGAGAACGTATTCAACAACAAATACGCGGAGAATATCACTTAGGTGATGTTGATTTGTATTATC
CTGGTGCCAGTCTTGGCATAGTAGAAGTCGATCCTGAAACGACCGATGCAGACAGTGCCCTGCATGCTGCCGATATCGCG
ATGTATCAGGAGAAAAAACATAAACAGAAAACACCTTTTGTCACGCATTCAGCGCTACATTCCTGA

Upstream 100 bases:

>100_bases
AAAACATATTACGCCTTGTTTCATCTTTGTTGATGATGTTTTATCATGCCTGCAAAGATTAAATAATCAGCATTTACCCG
CCGTATCCTGGAGTTGTTTC

Downstream 100 bases:

>100_bases
GGCGTATTCACATCCTTTTGATTGGTGATAACATGCGAATCGGTATTATTTTTCCGGTTGTAATCTTTATTACAGCGGTC
GTATTTTTAGCATGGTTTTT

Product: putative diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRA
IDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALV
EQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIA
MYQEKKHKQKTPFVTHSALHS

Sequences:

>Translated_341_residues
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRA
IDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALV
EQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIA
MYQEKKHKQKTPFVTHSALHS
>Mature_340_residues
SDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAI
DENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVE
QLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNT
LQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAM
YQEKKHKQKTPFVTHSALHS

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=341, Percent_Identity=98.8269794721408, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1787541, Length=163, Percent_Identity=33.7423312883436, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082007, Length=193, Percent_Identity=31.0880829015544, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788381, Length=172, Percent_Identity=30.8139534883721, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786584, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788956, Length=101, Percent_Identity=41.5841584158416, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787816, Length=162, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 38526; Mature: 38395

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCC
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGS
CEECCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCEECCCCC
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
CEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEHHHCCCCCCCEEEEEECHHHH
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
HHHHCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEE
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
SDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCC
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGS
CEECCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCEECCCCC
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
CEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEHHHCCCCCCCEEEEEECHHHH
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
HHHHCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEE
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]