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The map label for this gene is astC [H]

Identifier: 218689689

GI number: 218689689

Start: 1906734

End: 1907954

Strand: Reverse

Name: astC [H]

Synonym: ECED1_1950

Alternate gene names: 218689689

Gene position: 1907954-1906734 (Counterclockwise)

Preceding gene: 218689699

Following gene: 218689688

Centisome position: 36.62

GC content: 55.12

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTGATGAATGGATGATACCTGTTTACGCTCCGGCACCGTTTATACCGGTACG
TGGCGAAGGTTCACGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCATCCGGAACTGCGTGAGGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGCCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTCTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCACTAAAACTGGCGCGTAAATTCGCTCACGATCGCTACGGCAGCCATAAGAGCGGCATCGTGGCGT
TCAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTCAGTGCGGGTGGGCAGCCAGCCTATTCACAGGATTTTGCGCCA
CTGCCGCCGGATATTCGTCATGCTGCATATAACGATATTAACTCTGCCAGTGCGCTGATTGACGACGCCACCTGTGCGGT
GATTGTCGAACCCATCCAGGGGGAAGGCGGTGTGGTGCCAGCCAGCAACGCATTTTTACAAGGTCTGCGTGAATTGTGTG
ACCGCCACAATGCGTTGCTGATCTTTGATGAAGTACAAACCGGTGTCGGGCGCACCGGGGAACTGTATGCCTGTATGCAC
TACGGCGTGACGCCTGATCTGTTAACTACCGCCAAAGCGCTGGGCGGCGGTTTCCCGGTTGGTGCGTTGTTGGCAACCGA
AGAGTGCGCCAGCGTGATGACCGTTGGCACTCACGGCACCACCTATGGCGGCAATCCGCTGGCCTCGGCGGTGGCAGGCA
AAGTGCTGGATCTCATCAACACGCCAGAGATGCTTAACGGGGTTAAACAGCGTCACGACTGGTTTGTTGAGCGTCTAAAT
TCCATTAATCACCACTACAGTTTGTTCAGTGAAGTTCGCGGCTTAGGTCTTTTGATTGGCTGTGTACTGAATGCCGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAAGCGGTGAAAGCAGGCGTGATGGTGCTGATTGCGGGTGGCAACGTGGTGC
GCTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGCTGCTTGCGAACACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTTATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGCAAACATTACTTATTATTAACATATAAATAACGAAT
TATTTACTGTAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATTCGTCCCGTTGAGCGCTCAGATGTCTCGGCGCTGATGCAGCTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYACMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLN
SINHHYSLFSEVRGLGLLIGCVLNADYAGQAKQISQEAVKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYACMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLN
SINHHYSLFSEVRGLGLLIGCVLNADYAGQAKQISQEAVKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS
>Mature_405_residues
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
PVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYACMHY
GVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLNS
INHHYSLFSEVRGLGLLIGCVLNADYAGQAKQISQEAVKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=34.8284960422164, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.4948805460751, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=27.5395033860045, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=28.8416075650118, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=28.1323877068558, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=29.1237113402062, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=26.9417475728155, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI188536080, Length=432, Percent_Identity=23.8425925925926, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38679950, Length=432, Percent_Identity=23.8425925925926, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38679946, Length=432, Percent_Identity=23.8425925925926, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=97.5369458128079, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=60.2015113350126, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=34.6733668341709, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI145693181, Length=375, Percent_Identity=35.4666666666667, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=34.8717948717949, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1786349, Length=312, Percent_Identity=33.0128205128205, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=33.1081081081081, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=35.0383631713555, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=29.8850574712644, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=33.4494773519164, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=28.175519630485, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=34.5454545454545, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=26.2987012987013, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=40.0497512437811, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=400, Percent_Identity=32.75, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=29.2307692307692, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=26.5027322404372, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=35.3562005277045, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=29.2035398230088, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=29.2134831460674, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=361, Percent_Identity=29.3628808864266, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281366494, Length=424, Percent_Identity=24.7641509433962, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24667139, Length=424, Percent_Identity=24.7641509433962, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24667143, Length=424, Percent_Identity=24.7641509433962, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 43559; Mature: 43427

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHHCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEEHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHH
DDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYACMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNSINHHYSLFSEVRGLGLLIGCVLNADYAGQAKQISQEAVK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHHCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEEHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHH
DDATCAVIVEPIQGEGGVVPASNAFLQGLRELCDRHNALLIFDEVQTGVGRTGELYACMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNSINHHYSLFSEVRGLGLLIGCVLNADYAGQAKQISQEAVK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA