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The map label for this gene is rspB [H]

Identifier: 218689501

GI number: 218689501

Start: 1718781

End: 1719800

Strand: Reverse

Name: rspB [H]

Synonym: ECED1_1748

Alternate gene names: 218689501

Gene position: 1719800-1718781 (Counterclockwise)

Preceding gene: 218689502

Following gene: 218689500

Centisome position: 33.01

GC content: 45.39

Gene sequence:

>1020_bases
ATGAAAAGCATTTTAATTGAAAAACCGAATCAACTGTCGATTATCGAACGTGAAATACCCACCCCGTCAGCGGGTGAAGT
ACGAGTAAAAGTTAAACTTGCCGGAATTTGTGGTTCAGATAGCCATATTTACCGTGGGCATAATCCTTTTGCGAAATATC
CGCGCGTCATTGGTCATGAATTCTTTGGCGTCATTGATGCAGTGGGTGACGGCGTGGAAAGCGCCAGAGTCGGTGAACGC
GTTGCTGTCGATCCGGTGGTCAGCTGTGGGCATTGCTATCCGTGCTCTATAGGTAAGCCGAACGTTTGTACGACACTTGC
TGTATTAGGTGTGCACGCTGACGGTGGTTTCAGTGAATATGCCGTGGTGCCGGCAAAAAATGCGTGGAAAATTCCTGAAG
CAGTGGCCGATCAATATGCGGTGATGATTGAACCTTTTACCATTGCGGCTAACGTTACCGGTCATGGTCAACCGACTGAA
AATGATACCGTTCTGGTTTACGGTGCAGGTCCAATCGGCCTGACGATCGTTCAGGTATTAAAAGGCGTCTATAACGTTAA
GAATGTGATTGTTGCCGATCGCATTGATGAACGACTGGAAAAAGCGAAAGAGAGCGGGGCAGACTGGGCGATTAATAACA
GCCAGACACCGCTTGGCGAGATTTTCGCTGAAAAAGGCATCAAGCCGACATTAATTATCGATGCGGCTTGTCATCCTTCA
ATCCTGAAAGAAGCCGTAACGCTGGCTTCTCCAGCGGCACGTATTGTATTGATGGGCTTCTCCAGTGAACCGTCTGAAGT
GATTCAGCAAGGAATTACCGGAAAAGAACTCTCTATTTTCTCTTCACGCTTAAATGCAAATAAATTCCCGGTCGTTATCG
ACTGGTTAAGTAAAGGGTTAATTAAACCAGAAAAACTAATTACCCATACGTTTGATTTCCAGCATGTTGCGGATGCCATT
AGTTTATTTGAACTGGATCAAAAACATTGCTGCAAAGTCTTACTCACTTTTTCTGAATAA

Upstream 100 bases:

>100_bases
TCGATGAAAAGCTGGCGGCGAAATATCCCTATGAACCTGCTTATCTGCCAGTCGCACGTCTGGAAGATGGCACGCTGTGG
AACTGGTAAGGAGTAAGGTA

Downstream 100 bases:

>100_bases
TACCAATAACGGCGAGTAAGTAGTACGCATCTTACCTCTTTTTTAGAGATAACCATTATGATAATAGAAAAACACGAAAG
AAGTACTAAGGATTTGGTGA

Product: putative dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKSILIEKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDGVESARVGER
VAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEYAVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTE
NDTVLVYGAGPIGLTIVQVLKGVYNVKNVIVADRIDERLEKAKESGADWAINNSQTPLGEIFAEKGIKPTLIIDAACHPS
ILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGLIKPEKLITHTFDFQHVADAI
SLFELDQKHCCKVLLTFSE

Sequences:

>Translated_339_residues
MKSILIEKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDGVESARVGER
VAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEYAVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTE
NDTVLVYGAGPIGLTIVQVLKGVYNVKNVIVADRIDERLEKAKESGADWAINNSQTPLGEIFAEKGIKPTLIIDAACHPS
ILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGLIKPEKLITHTFDFQHVADAI
SLFELDQKHCCKVLLTFSE
>Mature_339_residues
MKSILIEKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGDGVESARVGER
VAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEYAVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTE
NDTVLVYGAGPIGLTIVQVLKGVYNVKNVIVADRIDERLEKAKESGADWAINNSQTPLGEIFAEKGIKPTLIIDAACHPS
ILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGLIKPEKLITHTFDFQHVADAI
SLFELDQKHCCKVLLTFSE

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=28.7878787878788, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI262073058, Length=375, Percent_Identity=26.6666666666667, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71743840, Length=375, Percent_Identity=26.6666666666667, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=24.7311827956989, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=24.6537396121884, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4501933, Length=251, Percent_Identity=29.8804780876494, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=363, Percent_Identity=25.8953168044077, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=25.6983240223464, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI34577061, Length=377, Percent_Identity=25.7294429708223, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=98.2300884955752, Blast_Score=685, Evalue=0.0,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=31.4121037463977, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790045, Length=318, Percent_Identity=30.188679245283, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=31.5315315315315, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1788073, Length=325, Percent_Identity=28.3076923076923, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=27.0348837209302, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87082125, Length=367, Percent_Identity=28.6103542234332, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=27.4853801169591, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786825, Length=394, Percent_Identity=23.8578680203046, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87081918, Length=269, Percent_Identity=29.7397769516729, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786552, Length=349, Percent_Identity=27.7936962750716, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082401, Length=129, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786518, Length=131, Percent_Identity=33.587786259542, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=29.3051359516616, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562878, Length=208, Percent_Identity=32.2115384615385, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=356, Percent_Identity=26.123595505618, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=358, Percent_Identity=25.9776536312849, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=126, Percent_Identity=34.1269841269841, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=304, Percent_Identity=23.3552631578947, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=349, Percent_Identity=27.2206303724928, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=349, Percent_Identity=27.2206303724928, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=343, Percent_Identity=25.9475218658892, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=222, Percent_Identity=31.0810810810811, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=26.1455525606469, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=212, Percent_Identity=28.7735849056604, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=314, Percent_Identity=25.796178343949, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=25.5520504731861, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=133, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137530, Length=327, Percent_Identity=26.9113149847095, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=25.8358662613982, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45551930, Length=323, Percent_Identity=22.6006191950464, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221457811, Length=323, Percent_Identity=22.6006191950464, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550770, Length=323, Percent_Identity=22.6006191950464, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737895, Length=201, Percent_Identity=26.865671641791, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 36521; Mature: 36521

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSILIEKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHE
CCCCEECCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCEECCCCCHHHHHHHHHHH
FFGVIDAVGDGVESARVGERVAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEY
HHHHHHHHCCCHHHHHCCCEEEECHHHHCCCEEECCCCCCCHHHEEEEEEEECCCCCCCE
AVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTENDTVLVYGAGPIGLTIVQVL
EEEECCCCCCCCHHHHCCEEEEEECEEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHH
KGVYNVKNVIVADRIDERLEKAKESGADWAINNSQTPLGEIFAEKGIKPTLIIDAACHPS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCCCEEEEECCCCHH
ILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGL
HHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEHHHCCC
IKPEKLITHTFDFQHVADAISLFELDQKHCCKVLLTFSE
CCCHHHHHHCCCHHHHHHHHHHHHCCHHHHEEEEEEECC
>Mature Secondary Structure
MKSILIEKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHE
CCCCEECCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCEECCCCCHHHHHHHHHHH
FFGVIDAVGDGVESARVGERVAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEY
HHHHHHHHCCCHHHHHCCCEEEECHHHHCCCEEECCCCCCCHHHEEEEEEEECCCCCCCE
AVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTENDTVLVYGAGPIGLTIVQVL
EEEECCCCCCCCHHHHCCEEEEEECEEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHH
KGVYNVKNVIVADRIDERLEKAKESGADWAINNSQTPLGEIFAEKGIKPTLIIDAACHPS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCCCEEEEECCCCHH
ILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGL
HHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEHHHCCC
IKPEKLITHTFDFQHVADAISLFELDQKHCCKVLLTFSE
CCCHHHHHHCCCHHHHHHHHHHHHCCHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]