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The map label for this gene is dhaL [H]

Identifier: 218689146

GI number: 218689146

Start: 1334854

End: 1335486

Strand: Reverse

Name: dhaL [H]

Synonym: ECED1_1347

Alternate gene names: 218689146

Gene position: 1335486-1334854 (Counterclockwise)

Preceding gene: 218689147

Following gene: 218689145

Centisome position: 25.64

GC content: 53.4

Gene sequence:

>633_bases
ATGTCACTGAGCAGAACTCAAATTGTTAACTGGCTCACTCGTTGTGGCGATATTTTCAGCACCGAGAGCAAGTATCTTAC
TGGACTGGATCGCGAGATTGGCGACGCTGACCACGGGCTAAATATGAATCGAGGCTTTAGCAAAGTGGTAGAAAAACTCC
CTGCTATCGCAGATAAAGATATCGGTTTCATTCTCAAGAATACCGGCATGACACTACTTTCCAGCGTCGGAGGTGCCAGT
GGTCCGCTGTTCGGTACCTTCTTTATCCGCGCCGCACAGACAACCCAGGCACGGCAAAGCCTGACGCTGGAAGAGCTTTA
TCAGATGTTCCGCGATGGCGCGGACGGCGTAATCAGTCGCGGGAAAGCCGAACCTGGCGATAAAACCATGTGTGATGTGT
GGGTGCCGGTGGTGGAATCGTTACGTCAGTCCTGCGAGCAAAATCTCCCTGTTCCGGCGGCGCTCGACGCTGCCAGTAGC
ATCGCCGAATCCGCTGCACAAAGTACGATTACGATGCAAGCCCGCAAAGGCCGCGCCAGTTATCTCGGTGAACGCAGTAT
TGGTCACCAGGATCCCGGCGCGACCTCGGTGATGTTTATGATGCAAATGTTGGCGTTAGCCGCAAAAGAGTAA

Upstream 100 bases:

>100_bases
TTCTCAATCACCTTACTGAAAGTTGATGACGAAACGCTGGCATTCTGGGACGCCCCTGTCCACACCCCGGCCCTTAACTG
GGGTAAATAAGGAGAAAGCA

Downstream 100 bases:

>100_bases
GGAATTGGTGATGGTAAACCTGGTCATAGTTTCACATAGCAGCCGACTGGGAGAAGGTGTCGGTGAATTAGCCCGTCAGA
TGTTAATGAGTGATAGTTGT

Product: dihydroxyacetone kinase subunit DhaL

Products: ADP; glycerone phosphate

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSLSRTQIVNWLTRCGDIFSTESKYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGAS
GPLFGTFFIRAAQTTQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSCEQNLPVPAALDAASS
IAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE

Sequences:

>Translated_210_residues
MSLSRTQIVNWLTRCGDIFSTESKYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGAS
GPLFGTFFIRAAQTTQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSCEQNLPVPAALDAASS
IAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE
>Mature_209_residues
SLSRTQIVNWLTRCGDIFSTESKYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASG
PLFGTFFIRAAQTTQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSCEQNLPVPAALDAASSI
AESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE

Specific function: ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL- ADP receives a phosphoryl group from dhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sens

COG id: COG2376

COG function: function code G; Dihydroxyacetone kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DhaL domain [H]

Homologues:

Organism=Homo sapiens, GI20149621, Length=182, Percent_Identity=32.4175824175824, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787449, Length=210, Percent_Identity=97.1428571428571, Blast_Score=396, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6323570, Length=193, Percent_Identity=26.9430051813472, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004007
- InterPro:   IPR012737 [H]

Pfam domain/function: PF02734 Dak2 [H]

EC number: 2.7.1.29

Molecular weight: Translated: 22645; Mature: 22514

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSRTQIVNWLTRCGDIFSTESKYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKD
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
IGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQTTQARQSLTLEELYQMFRDGADGVISR
CHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHC
GKAEPGDKTMCDVWVPVVESLRQSCEQNLPVPAALDAASSIAESAAQSTITMQARKGRAS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHH
YLGERSIGHQDPGATSVMFMMQMLALAAKE
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLSRTQIVNWLTRCGDIFSTESKYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKD
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
IGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQTTQARQSLTLEELYQMFRDGADGVISR
CHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHC
GKAEPGDKTMCDVWVPVVESLRQSCEQNLPVPAALDAASSIAESAAQSTITMQARKGRAS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHH
YLGERSIGHQDPGATSVMFMMQMLALAAKE
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; glycerone

Specific reaction: ATP + glycerone = ADP + glycerone phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10493123 [H]