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The map label for this gene is bioC [H]

Identifier: 218688562

GI number: 218688562

Start: 770424

End: 771179

Strand: Direct

Name: bioC [H]

Synonym: ECED1_0741

Alternate gene names: 218688562

Gene position: 770424-771179 (Clockwise)

Preceding gene: 218688561

Following gene: 218688563

Centisome position: 14.79

GC content: 56.08

Gene sequence:

>756_bases
ATGGCAACGGTTAATAAACAAGCCATTGCTGCGGCATTTGGACGGGCAGCCGCACACTATGAGCAACATGCCGATCTACA
GCGCCAGAGTGCTGACGCCTTACTGGCAATGCTCCCACAGCGTAAATACACCCACGTACTGGATGCGGGTTGTGGACCAG
GCTGGATGAGCCGCCGCTGGCGAGAGCGTCACGCGCAGGTGACTGCGTTAGATCTCTCGCCGCCAATGCTTGTTCAGGCA
CGCCAGAAGGATGCCGCAGACCATTATCTGGCGGGAGATATCGAATCCCTGCCGTTAGCGACTGCGACGTTCGATCTTGC
ATGGAGCAATCTCGTGGTGCAGTGGTGCGGTAATTTATCCATGGCACTCCGCGAGCTGTATCGGGTGGTGCGCCCCGGAG
GCGTGGTCGCGTTTACCACGCTGGTGCAGGGATCGTTACCCGAACTGCATCAGGCGTGGCAGGCGGTGGACGAGCGCCCG
CATGCTAATCGCTTTTTACCGCCAGATAAAATCGAACAGTCGCTAAACGCCGTTCATTATCAACATTATATTCAGCCCAT
CACGCTGTGGTTTGATGATGCGCTCAGTGCCATGCGTTCGCTGAAAGGCATCGGTGCCACGCATCTTCATGAAGGGCGTG
ACCCGCGAATATTAACGCGTTCGCAGTTGCAGCGATTGCAACTGGCCTGGCCGCAACAACAGGGGCGATATCCTCTGACG
TATCATCTTTTTTTGGGAGTGATTGCTCGTGAGTAA

Upstream 100 bases:

>100_bases
ATTCGCCCGCCAACCGTACCCGCTGGTACTGCGCGACTGCGCTTAACGCTAACCGCAGCGCATGAAATGCAGGATATCGA
CCGTCTGCTGGAGGTGCTGC

Downstream 100 bases:

>100_bases
ATGTTATTTTGTCACCGGAACGGATACCGAAGTGGGGAAAACTGTCGCCAGCTGCGCGCTTTTACAAGCCGCAAAGGCAG
CAGGCTACCGGACGGCAGGT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRRWRERHAQVTALDLSPPMLVQA
RQKDAADHYLAGDIESLPLATATFDLAWSNLVVQWCGNLSMALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP
HANRFLPPDKIEQSLNAVHYQHYIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT
YHLFLGVIARE

Sequences:

>Translated_251_residues
MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRRWRERHAQVTALDLSPPMLVQA
RQKDAADHYLAGDIESLPLATATFDLAWSNLVVQWCGNLSMALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP
HANRFLPPDKIEQSLNAVHYQHYIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT
YHLFLGVIARE
>Mature_250_residues
ATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRRWRERHAQVTALDLSPPMLVQAR
QKDAADHYLAGDIESLPLATATFDLAWSNLVVQWCGNLSMALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERPH
ANRFLPPDKIEQSLNAVHYQHYIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLTY
HLFLGVIARE

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786994, Length=251, Percent_Identity=97.2111553784861, Blast_Score=477, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 28322; Mature: 28191

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRRW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHH
RERHAQVTALDLSPPMLVQARQKDAADHYLAGDIESLPLATATFDLAWSNLVVQWCGNLS
HHHCCEEEEEECCCCHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
MALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERPHANRFLPPDKIEQSLNAVHY
HHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QHYIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEECHHHHHHHHHCCCHHCCCCCCH
YHLFLGVIARE
HHHHHHHHHCC
>Mature Secondary Structure 
ATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRRW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHH
RERHAQVTALDLSPPMLVQARQKDAADHYLAGDIESLPLATATFDLAWSNLVVQWCGNLS
HHHCCEEEEEECCCCHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
MALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERPHANRFLPPDKIEQSLNAVHY
HHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QHYIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEECHHHHHHHHHCCCHHCCCCCCH
YHLFLGVIARE
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]