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The map label for this gene is cysQ [H]

Identifier: 218551491

GI number: 218551491

Start: 4378616

End: 4379356

Strand: Direct

Name: cysQ [H]

Synonym: EFER_4274

Alternate gene names: 218551491

Gene position: 4378616-4379356 (Clockwise)

Preceding gene: 218551489

Following gene: 218551493

Centisome position: 95.42

GC content: 53.04

Gene sequence:

>741_bases
ATGTTAGAACAAGTATGCCTACTTGCACGGATGGCGGGCGACGCCATTATGCAAGTTTATGATGGAACAGTACCGATGGA
TGTCGCCAGTAAAGCCGATAACTCCCCGGTGACGGCTGCAGACATTGCCGCGCATACCGTCATCATGGACGGTTTACGTA
CGCTGACGCCGGATATCCCGGTTCTCTCCGAAGAAGATCCGCCCGGCTGGGAAGTCCGCCAGCACTGGCAGCGTTACTGG
CTGGTTGATCCGCTGGATGGCACCAAAGAGTTTATTAAACGTAATGGCGAATTCACGGTAAACATTGCCTTGATCGACAA
AGGCAAACCAATTCTGGGTGTGGTGTACGCGCCGGTAATGAAGGTGATGTACAGCGCGGCAGAAGGAAAAGCCTGGAAAG
ATGAAAATGGTATACGTAAGCAGATTCAGGTACGTGATGCTCGCCCACCGCTGGTGGTGATCAGCCGTTCCCATGCCGAT
GCGGAATTGAAAGAATATCTACAACAACTTGGCGAACACCAGACGACCTCAATTGGCTCCTCACTGAAGTTCTGCCTGGT
GGCGGAAGGGCAGGCTCAACTCTATCCGCGTTTCGGGCCAACTAATATTTGGGATACCGCTGCCGGTCACGCAGTTGCGG
CAGCGGCCGGGGCGCATGTTAATGACTGGCAGGGTAAACCTCTGGATTACACTCCGCGTGAATCATTCCTGAACCCCGGT
TTTCGTGTCTCTATTTACTAA

Upstream 100 bases:

>100_bases
CGCTTTGAAAATGATGACACTATCACAGTTGGCGCATTCTTTATTGATAGGGTATAAGTAAAACAACGAGTTAACACCAC
TGAAACAAAAGAGGTGGAAA

Downstream 100 bases:

>100_bases
GTAATTTATGCAGCAGGTCCATTACCTGCTGCACCTCTTGCTGAGTTAAAGCACCATCCTTCGCCCATTGCACGCGTCCG
TCTTTATCCAACACCGCAAT

Product: adenosine-3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLEQVCLLARMAGDAIMQVYDGTVPMDVASKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDKGKPILGVVYAPVMKVMYSAAEGKAWKDENGIRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVNDWQGKPLDYTPRESFLNPG
FRVSIY

Sequences:

>Translated_246_residues
MLEQVCLLARMAGDAIMQVYDGTVPMDVASKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDKGKPILGVVYAPVMKVMYSAAEGKAWKDENGIRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVNDWQGKPLDYTPRESFLNPG
FRVSIY
>Mature_246_residues
MLEQVCLLARMAGDAIMQVYDGTVPMDVASKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDKGKPILGVVYAPVMKVMYSAAEGKAWKDENGIRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVNDWQGKPLDYTPRESFLNPG
FRVSIY

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=240, Percent_Identity=28.75, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI221625487, Length=240, Percent_Identity=28.75, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790659, Length=246, Percent_Identity=95.1219512195122, Blast_Score=456, Evalue=1e-130,
Organism=Escherichia coli, GI1788882, Length=234, Percent_Identity=29.4871794871795, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71995897, Length=270, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71995905, Length=269, Percent_Identity=26.3940520446097, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641722, Length=230, Percent_Identity=26.5217391304348, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357303, Length=162, Percent_Identity=30.2469135802469, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 27142; Mature: 27142

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQVCLLARMAGDAIMQVYDGTVPMDVASKADNSPVTAADIAAHTVIMDGLRTLTPDIP
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDKGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHEEEECCCCHHHHHHHCCCCEEEEEEEEECCCCEEHHHHHHHH
KVMYSAAEGKAWKDENGIRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVNDWQGKPLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHCCCC
FRVSIY
EEEEEC
>Mature Secondary Structure
MLEQVCLLARMAGDAIMQVYDGTVPMDVASKADNSPVTAADIAAHTVIMDGLRTLTPDIP
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDKGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHEEEECCCCHHHHHHHCCCCEEEEEEEEECCCCEEHHHHHHHH
KVMYSAAEGKAWKDENGIRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVNDWQGKPLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHCCCC
FRVSIY
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]