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The map label for this gene is ubiA [H]

Identifier: 218551352

GI number: 218551352

Start: 4231144

End: 4232016

Strand: Direct

Name: ubiA [H]

Synonym: EFER_4131

Alternate gene names: 218551352

Gene position: 4231144-4232016 (Clockwise)

Preceding gene: 218551351

Following gene: 218551354

Centisome position: 92.21

GC content: 49.6

Gene sequence:

>873_bases
ATGGAGTGGAGTCTGACGCAGAATAAGCTGTTGGCGTTTCACCGCTTAATGCGTACGGATAAGCCAATTGGCGCGTTACT
ACTGCTCTGGCCAACCCTGTGGGCACTTTGGGTGGCTACACCAGGCGTGCCACCATTGTGGATTCTGGCAGTATTTGTGG
CTGGAGTCTGGCTAATGCGGGCCGCCGGGTGTGTGGTTAACGATTATGCTGATCGTAAATTTGACGGTCATGTTAAACGC
ACCGCAAACCGACCGTTGCCCAGCGGTGCGGTAACCGAAAAAGAAGCCCGGACGTTGTTTGTGGTGTTGGTGCTGCTGGC
ATTTTTGCTGGTACTGACACTGAACACGATGACGATTCTGTTATCTGTAGCCGCACTGGCACTGGCCTGGGTTTACCCAT
TTATGAAGCGCTACACGCATTTACCGCAAGTGGTATTGGGCGCGGCATTTGGTTGGTCGATCCCTATGGCTTTTGCTGCG
GTTAGTGAGTCGGTGCCGCTTAGCTGCTGGTTGATGTTCCTTGCGAATATCCTTTGGGCAGTTGCTTATGATACTCAGTA
CGCGATGGTTGACCGCGATGACGATGTTAAAATTGGCATTAAATCCACGGCGATCCTGTTTGGGCAATACGATAAATTTA
TTATCGGCGTATTACAGATTGGCGTGATGGTATTAATGGCGCTGATTGGTTGGCTTAACGGCCTAGACTGGGGCTATTAC
TGGTCGATTCTGGTTGCAGGTGGTCTGTTTGTTTATCAACAAAAGCTGATTGCCAACCGTGAGCGTGAAGCCTGTTTTAA
GGCGTTTATGAATAATAACTATGTTGGCCTGGTGCTGTTTTTAGGGCTGGCAATGAGTTACTGGCATTTTTGA

Upstream 100 bases:

>100_bases
GCTATGGGGGCGGCGTTCACGTCTGCGGTTAAGCGGTAAGCCCCTGATGCTTACTGAACTGTTTTTGCCTGCATCACCGT
TGTACTAAGAGGAAATAAAG

Downstream 100 bases:

>100_bases
TTTTGTTAATTTAATAAAAAAAACCGGTCACTTGACCGGTTTTTTATTATCTTGATTTACTCGCCCTGCGTCGCACTTTC
AATCGTCAGACGCACATCAG

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPPLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARTLFVVLVLLAFLLVLTLNTMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKFIIGVLQIGVMVLMALIGWLNGLDWGYY
WSILVAGGLFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Sequences:

>Translated_290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPPLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARTLFVVLVLLAFLLVLTLNTMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKFIIGVLQIGVMVLMALIGWLNGLDWGYY
WSILVAGGLFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
>Mature_290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPPLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARTLFVVLVLLAFLLVLTLNTMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKFIIGVLQIGVMVLMALIGWLNGLDWGYY
WSILVAGGLFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=282, Percent_Identity=35.1063829787234, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1790473, Length=290, Percent_Identity=95.5172413793103, Blast_Score=543, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI32565247, Length=281, Percent_Identity=35.9430604982206, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=35.9154929577465, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17553720, Length=338, Percent_Identity=31.0650887573964, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=43.9716312056738, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=43.5714285714286, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324370, Length=300, Percent_Identity=32, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355567, Length=276, Percent_Identity=37.3188405797101, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32648; Mature: 32648

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPPLWILAVFVAGVWLMR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARTLFVVLVLLAFLLVLTLNTMTIL
HCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKFIIGVLQIGVMVLMALIGWLNGLDWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WSILVAGGLFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPPLWILAVFVAGVWLMR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARTLFVVLVLLAFLLVLTLNTMTIL
HCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKFIIGVLQIGVMVLMALIGWLNGLDWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WSILVAGGLFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA