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The map label for this gene is hemN [H]

Identifier: 218551137

GI number: 218551137

Start: 3997523

End: 3998773

Strand: Direct

Name: hemN [H]

Synonym: EFER_3898

Alternate gene names: 218551137

Gene position: 3997523-3998773 (Clockwise)

Preceding gene: 218551136

Following gene: 218551138

Centisome position: 87.12

GC content: 47.4

Gene sequence:

>1251_bases
ATGGCAAAACCGATGAATAATGAATCGATTTATCAGCAATATATGTACAGTTACCCGCATAAGACCGCTTATCGGGAATT
AAACAATATTGCTTTTGCGGATGTGAAGTCGCGTATTTACGAGCATAAAACACATCTCTATATTCATATGCCCTTTTGCC
AGAGCCGCTGCGGGTTTTGTAATCTCTTTTCCTGCACGGGAGCAGACAATGCCTTTATCGACAACTACATAGAGGCGATT
ATTGTCCAGGCCCGGCAAATGCAACTTGCGCCTGTAGACTGGGCCAGTTTTACCATTGGCGGCGGTACGCCATTGCTGCT
TAATGTCGGGCAACTGTCGCGGTTGTTTAGCAGGGTGTTTGACGAATTACAAGTCGATGCGCAGATTTTTAAGGCAATTG
AAACATCGCCTTCCGATACCACCGCCGAAAAAGTCGCGTTGCTGTGCCAGCTTGCGGTAAACCGCGTCAGTATTGGCATT
CAGAGTTTTAACGATCTGGAACTTGCCACATTACACCGCCGCCATAGTGCGGAAAATGCCCATCGGGCGCTGGAGCTACT
GCGCAGGGGTAATTTCCCGATACTCAATATTGATATTATTTACGGTATTCCCGGTCAAACAGCCACAAGTTTAATGGCGT
CACTTAATCAGGCATTAGATTATCAGCCTGACGAACTTTTTTTGTACCCGCTGTATAACATGCCGCGCCAGCCGGATATG
TATAGCCTCTATATTGAAGCCCGCGATCGCTTATTGCATGAAGGTTATACGCAAACGTCAATGCGCCGTTTTGTGCGGGT
GAATAATGAGTCGACGGCTGAAAGTTGTGGCTTTGAAAATTCGCTGGCACTTGGCGCGGGCGGGCGCAGTTATCTTGGCA
ATTTACATTACTGCACGCCGTGGTCGCAAAACCAGCCCGCATCGCGACAAATTGTCGCGAATTTTATCGCCCGGCCAGAT
AAAACCCAAATTCACCACGGCTATGTCCTTTCACAAGCAGAAATGAAGCGGCGTTTTATTATCAAGAATCTCTTTTTCTA
TAAAGGACTTTCGTTAAGCGATTATCAGCACCAGTTCTTCTCTGAGGTATTAAGCGATTTTCCCCTGCTGGGAGATTTCA
TCAAACAAGATTACTGCCACCAGCAGGATAACCGCATTCTGCTCACCGTGCAGGGTTTAGCGCTTTCGGACCAGCTTGGC
CCGCAGTTTATTTCCCCGGAAGTTCACAGTCTGGAGACGCATAAACGATGA

Upstream 100 bases:

>100_bases
TGTTCCGATCATGGCACTTGCTACGGGGAAGACGGAAAATATTTCCACAGTTTTAACCATCCGATTGTGAATACCGTACC
CTATTTTCACTTTGTGTTAG

Downstream 100 bases:

>100_bases
CGCTCAAGCAGATCCAGACGCTGATTTATCGCGGCGAGATAAAGTCGTGTAATTATCGCTGTGGTTATTGCCCTTTTCAT
AAACAAGACCGCAATGATAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAKPMNNESIYQQYMYSYPHKTAYRELNNIAFADVKSRIYEHKTHLYIHMPFCQSRCGFCNLFSCTGADNAFIDNYIEAI
IVQARQMQLAPVDWASFTIGGGTPLLLNVGQLSRLFSRVFDELQVDAQIFKAIETSPSDTTAEKVALLCQLAVNRVSIGI
QSFNDLELATLHRRHSAENAHRALELLRRGNFPILNIDIIYGIPGQTATSLMASLNQALDYQPDELFLYPLYNMPRQPDM
YSLYIEARDRLLHEGYTQTSMRRFVRVNNESTAESCGFENSLALGAGGRSYLGNLHYCTPWSQNQPASRQIVANFIARPD
KTQIHHGYVLSQAEMKRRFIIKNLFFYKGLSLSDYQHQFFSEVLSDFPLLGDFIKQDYCHQQDNRILLTVQGLALSDQLG
PQFISPEVHSLETHKR

Sequences:

>Translated_416_residues
MAKPMNNESIYQQYMYSYPHKTAYRELNNIAFADVKSRIYEHKTHLYIHMPFCQSRCGFCNLFSCTGADNAFIDNYIEAI
IVQARQMQLAPVDWASFTIGGGTPLLLNVGQLSRLFSRVFDELQVDAQIFKAIETSPSDTTAEKVALLCQLAVNRVSIGI
QSFNDLELATLHRRHSAENAHRALELLRRGNFPILNIDIIYGIPGQTATSLMASLNQALDYQPDELFLYPLYNMPRQPDM
YSLYIEARDRLLHEGYTQTSMRRFVRVNNESTAESCGFENSLALGAGGRSYLGNLHYCTPWSQNQPASRQIVANFIARPD
KTQIHHGYVLSQAEMKRRFIIKNLFFYKGLSLSDYQHQFFSEVLSDFPLLGDFIKQDYCHQQDNRILLTVQGLALSDQLG
PQFISPEVHSLETHKR
>Mature_415_residues
AKPMNNESIYQQYMYSYPHKTAYRELNNIAFADVKSRIYEHKTHLYIHMPFCQSRCGFCNLFSCTGADNAFIDNYIEAII
VQARQMQLAPVDWASFTIGGGTPLLLNVGQLSRLFSRVFDELQVDAQIFKAIETSPSDTTAEKVALLCQLAVNRVSIGIQ
SFNDLELATLHRRHSAENAHRALELLRRGNFPILNIDIIYGIPGQTATSLMASLNQALDYQPDELFLYPLYNMPRQPDMY
SLYIEARDRLLHEGYTQTSMRRFVRVNNESTAESCGFENSLALGAGGRSYLGNLHYCTPWSQNQPASRQIVANFIARPDK
TQIHHGYVLSQAEMKRRFIIKNLFFYKGLSLSDYQHQFFSEVLSDFPLLGDFIKQDYCHQQDNRILLTVQGLALSDQLGP
QFISPEVHSLETHKR

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=277, Percent_Identity=27.7978339350181, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082341, Length=430, Percent_Identity=25.1162790697674, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789325, Length=242, Percent_Identity=26.4462809917355, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 47580; Mature: 47448

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPMNNESIYQQYMYSYPHKTAYRELNNIAFADVKSRIYEHKTHLYIHMPFCQSRCGFC
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCEE
NLFSCTGADNAFIDNYIEAIIVQARQMQLAPVDWASFTIGGGTPLLLNVGQLSRLFSRVF
EEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCCCEEEEEHHHHHHHHHHHH
DELQVDAQIFKAIETSPSDTTAEKVALLCQLAVNRVSIGIQSFNDLELATLHRRHSAENA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHH
HRALELLRRGNFPILNIDIIYGIPGQTATSLMASLNQALDYQPDELFLYPLYNMPRQPDM
HHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
YSLYIEARDRLLHEGYTQTSMRRFVRVNNESTAESCGFENSLALGAGGRSYLGNLHYCTP
EEEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCEEECCCCHHHHCCCEEECC
WSQNQPASRQIVANFIARPDKTQIHHGYVLSQAEMKRRFIIKNLFFYKGLSLSDYQHQFF
CCCCCCHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SEVLSDFPLLGDFIKQDYCHQQDNRILLTVQGLALSDQLGPQFISPEVHSLETHKR
HHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECEEECHHCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
AKPMNNESIYQQYMYSYPHKTAYRELNNIAFADVKSRIYEHKTHLYIHMPFCQSRCGFC
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCEE
NLFSCTGADNAFIDNYIEAIIVQARQMQLAPVDWASFTIGGGTPLLLNVGQLSRLFSRVF
EEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCCCEEEEEHHHHHHHHHHHH
DELQVDAQIFKAIETSPSDTTAEKVALLCQLAVNRVSIGIQSFNDLELATLHRRHSAENA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHH
HRALELLRRGNFPILNIDIIYGIPGQTATSLMASLNQALDYQPDELFLYPLYNMPRQPDM
HHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
YSLYIEARDRLLHEGYTQTSMRRFVRVNNESTAESCGFENSLALGAGGRSYLGNLHYCTP
EEEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCEEECCCCHHHHCCCEEECC
WSQNQPASRQIVANFIARPDKTQIHHGYVLSQAEMKRRFIIKNLFFYKGLSLSDYQHQFF
CCCCCCHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SEVLSDFPLLGDFIKQDYCHQQDNRILLTVQGLALSDQLGPQFISPEVHSLETHKR
HHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECEEECHHCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]