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The map label for this gene is cytR [H]

Identifier: 218551082

GI number: 218551082

Start: 3935455

End: 3936480

Strand: Direct

Name: cytR [H]

Synonym: EFER_3838

Alternate gene names: 218551082

Gene position: 3935455-3936480 (Clockwise)

Preceding gene: 218551081

Following gene: 218551083

Centisome position: 85.76

GC content: 48.93

Gene sequence:

>1026_bases
GTGAAGCTGAAGAAGCAGGTGACTGCCGCTACAATGAAAGATGTTGCACTGAAGGCAAAGGTCTCCACTGCAACTGTGTC
CCGCGCGTTAATGAATCCAGATAAAGTCTCCCAGGCAACACGTAGCCGGGTTGAACAGGCCGCCAGGGAAGTAGGGTATT
TGCCGCAAACTATGGGGCGAAACGCGAAACGTAATGAATCACGCACCATTCTGGTGATTGTCCCGGATATTTGCGATCCC
TTCTTTCATGACGTTATCAGGGGTGTTGAAGTCACAGCTGCCGAACAGGGATATCTGGTATTAATTGGCGATTGCGCCCA
TCAGAATCAGCAAGAAAAGACGTTTATCAATTTAATTGTTACTAAACAAATCGATGGCATGGTGCTGTTGAGTTCCCGCT
TGCCATTTAACGCCAGCGTAGAAGAGCAGCGTAATTTACCGCCGATGGTGATGTCGAACGAATTTGCCCCGGAACTGGAG
TTACCTACAGTTCATATCGACAACCTTACGGCATCATTTAACGCAATCAATTATTTGCTCAGTCTTGGGCATCGGCGTAT
CGGTTGTATCGCCGGGCCGGAAGATATGCCCTTCTGCCACTATCGCTTACAAGGGTACGTGCAGGCGTTGCGTCGTAATG
CCATCACCGTTAATCCACACTATATTGCCCGCGGTGATTTTACTTATGAGGCAGGTGGCAATGCGTTAAAGCAACTGCTC
GATCAACCAGAACCGCCAACAGCTATCTTTTGCCATAGCGATGTCATGGCTGTTGGGGCTATCTCCAGTGCTAAACGTAT
GGGGCTGAAAGTCCCGGATGATGTGTCAATTATGGGATTCGACAATATCGCCCTGGCCGAACATTGTGATCCGCCACTGA
CCACTATCGCCCAACCGCGTTACGAGATTGGTCGTGAAGCCATGCTCTTATTACTGGAACAAATTCATGGCCACGATGTG
AGTAATGGATCCCGATTAATGGACTGCGAACTGATCGTTCGTGAATCCACACGCGCTTTAACATAA

Upstream 100 bases:

>100_bases
AAAATTCTGTAACCGCTTCCACTAACTATCTGATAAAAATGTGTCGAAAACGAGTTAAACAAGGATTGTTCTGCGCCAGA
GTTTCAGGCGAGGAGAGAAA

Downstream 100 bases:

>100_bases
AGTCACTGGCTTTAAGACTTCCGTGTCTGGTCAAAGGCCCGTCGCTTAAGTAACATGGCGGGCTGATGAACGAATAAATA
CAGCGAAACGATAGTGGCAC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKLKKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQATRSRVEQAAREVGYLPQTMGRNAKRNESRTILVIVPDICDP
FFHDVIRGVEVTAAEQGYLVLIGDCAHQNQQEKTFINLIVTKQIDGMVLLSSRLPFNASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTASFNAINYLLSLGHRRIGCIAGPEDMPFCHYRLQGYVQALRRNAITVNPHYIARGDFTYEAGGNALKQLL
DQPEPPTAIFCHSDVMAVGAISSAKRMGLKVPDDVSIMGFDNIALAEHCDPPLTTIAQPRYEIGREAMLLLLEQIHGHDV
SNGSRLMDCELIVRESTRALT

Sequences:

>Translated_341_residues
MKLKKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQATRSRVEQAAREVGYLPQTMGRNAKRNESRTILVIVPDICDP
FFHDVIRGVEVTAAEQGYLVLIGDCAHQNQQEKTFINLIVTKQIDGMVLLSSRLPFNASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTASFNAINYLLSLGHRRIGCIAGPEDMPFCHYRLQGYVQALRRNAITVNPHYIARGDFTYEAGGNALKQLL
DQPEPPTAIFCHSDVMAVGAISSAKRMGLKVPDDVSIMGFDNIALAEHCDPPLTTIAQPRYEIGREAMLLLLEQIHGHDV
SNGSRLMDCELIVRESTRALT
>Mature_341_residues
MKLKKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQATRSRVEQAAREVGYLPQTMGRNAKRNESRTILVIVPDICDP
FFHDVIRGVEVTAAEQGYLVLIGDCAHQNQQEKTFINLIVTKQIDGMVLLSSRLPFNASVEEQRNLPPMVMSNEFAPELE
LPTVHIDNLTASFNAINYLLSLGHRRIGCIAGPEDMPFCHYRLQGYVQALRRNAITVNPHYIARGDFTYEAGGNALKQLL
DQPEPPTAIFCHSDVMAVGAISSAKRMGLKVPDDVSIMGFDNIALAEHCDPPLTTIAQPRYEIGREAMLLLLEQIHGHDV
SNGSRLMDCELIVRESTRALT

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=340, Percent_Identity=82.0588235294118, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1787948, Length=309, Percent_Identity=35.9223300970874, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1790194, Length=309, Percent_Identity=34.6278317152104, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=31.7241379310345, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788474, Length=308, Percent_Identity=32.4675324675325, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789068, Length=333, Percent_Identity=30.9309309309309, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI48994940, Length=322, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787580, Length=315, Percent_Identity=27.3015873015873, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=26.6666666666667, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=26.2686567164179, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1787906, Length=308, Percent_Identity=23.7012987012987, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789456, Length=315, Percent_Identity=25.7142857142857, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=20.7119741100324, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37720; Mature: 37720

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQATRSRVEQAAREVGYLPQTMGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHCC
NAKRNESRTILVIVPDICDPFFHDVIRGVEVTAAEQGYLVLIGDCAHQNQQEKTFINLIV
CCCCCCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCCEEEEECCCCCCCCHHEEEEEEE
TKQIDGMVLLSSRLPFNASVEEQRNLPPMVMSNEFAPELELPTVHIDNLTASFNAINYLL
EECCCCEEEEECCCCCCCCHHHHHCCCCEEECCCCCCCCCCCEEEECCCHHHHHHHHHHH
SLGHRRIGCIAGPEDMPFCHYRLQGYVQALRRNAITVNPHYIARGDFTYEAGGNALKQLL
HHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCEEEECCEEEECCCHHHHHHH
DQPEPPTAIFCHSDVMAVGAISSAKRMGLKVPDDVSIMGFDNIALAEHCDPPLTTIAQPR
CCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEHHHCCCCCHHHHCCCH
YEIGREAMLLLLEQIHGHDVSNGSRLMDCELIVRESTRALT
HHHHHHHHHHHHHHHHCCCCCCCCEEEEHEEEEECHHCCCC
>Mature Secondary Structure
MKLKKQVTAATMKDVALKAKVSTATVSRALMNPDKVSQATRSRVEQAAREVGYLPQTMGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHCC
NAKRNESRTILVIVPDICDPFFHDVIRGVEVTAAEQGYLVLIGDCAHQNQQEKTFINLIV
CCCCCCCCEEEEEECCCCCHHHHHHHCCCEEEECCCCCEEEEECCCCCCCCHHEEEEEEE
TKQIDGMVLLSSRLPFNASVEEQRNLPPMVMSNEFAPELELPTVHIDNLTASFNAINYLL
EECCCCEEEEECCCCCCCCHHHHHCCCCEEECCCCCCCCCCCEEEECCCHHHHHHHHHHH
SLGHRRIGCIAGPEDMPFCHYRLQGYVQALRRNAITVNPHYIARGDFTYEAGGNALKQLL
HHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCEEEECCEEEECCCHHHHHHH
DQPEPPTAIFCHSDVMAVGAISSAKRMGLKVPDDVSIMGFDNIALAEHCDPPLTTIAQPR
CCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEHHHCCCCCHHHHCCCH
YEIGREAMLLLLEQIHGHDVSNGSRLMDCELIVRESTRALT
HHHHHHHHHHHHHHHHCCCCCCCCEEEEHEEEEECHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]