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The map label for this gene is gpp [H]

Identifier: 218550996

GI number: 218550996

Start: 3819512

End: 3820996

Strand: Direct

Name: gpp [H]

Synonym: EFER_3725

Alternate gene names: 218550996

Gene position: 3819512-3820996 (Clockwise)

Preceding gene: 218550995

Following gene: 218550998

Centisome position: 83.24

GC content: 52.59

Gene sequence:

>1485_bases
ATGGGTTCCACCTCGTCATTATATGCAGCCATTGATCTCGGTTCGAATAGTTTTCATATGCTGGTTGTGCGCGAGGTGGC
TGGAAGCATCCAGACGCTGACGCGAATTAAACGCAAAGTGCGTCTGGCTGCGGGCCTGAACAGCGAAAATGCCCTGTCTA
ATGAAGCAATGGAGCGCGGTTGGCAATGTTTGCGCCTGTTTGCTGAACGTCTGCAAGATATCCCTCCCTCGCAAATTCGC
GTTGTCGCCACGGCGACATTACGCCTTGCCGTCAATGCCGGTGATTTTATTGCCAAAGCGCAGGAAATCCTCGGTTGTCC
GGTACAAGTGATCAGCGGTGAAGAAGAAGCTCGCCTGATTTATCAGGGCGTTGCTCACACCACTGGCGGTGCCGATCAGC
GCCTGGTGGTGGATATCGGCGGCGCCAGTACTGAACTGGTAACCGGCACGGGCGCACAAACCACCTCGTTGTTCAGCCTG
TCGATGGGCTGCGTCACCTGGCTGGAACGCTATTTTGCCGATCGTAATCTGGGGCAGGAAAATTTTGATGCCGCAGAAAA
AGCGGCACGCGAAGTGTTACGTCCGGTTGCCGATGAATTGCGGTATCACGGCTGGAAAGTATGCGTTGGTGCTTCCGGCA
CTGTGCAGGCCTTACAAGAAATCATGATGGCACAGGGGATGGATGAACGCATTACCCTGGAAAAGTTGCAGCAATTGAAA
CAGCGCGCCATTCATTGCGGTCGGTTGGAGGAACTGGAGATTGACGGGCTGACGCTGGAACGTGCGTTAGTGTTCCCGAG
TGGTCTGGCGATCCTGATAGCCATTTTTACCGAACTGAATATTCAGTGTATGACCCTGGCTGGCGGTGCACTGCGTGAAG
GCCTGGTCTACGGCATGTTGCATCTGGCCGTCGAGCAGGATATTCGCAGCCGTACGCTGCGTAATATTCAACGCCGCTTT
ATGATCGATATTGATCAGGCTCAGCGAGTAGCCAAAGTTGCGGCTAACTTCTTCGATCAGGTGGAAAACGAATGGCATCT
TGAAGCAATAAGCCGTGATTTGCTCATCAGCGCCTGTCAGCTTCATGAAATCGGTCTGAGCGTTGATTTCAAACAAGCGC
CGCAACATGCTGCTTATCTGGTGCGTAATCTGGATCTTCCCGGTTTTACGCCTGCACAGAAAAAATTACTGGCGACGCTA
CTACTCAACCAGACGAACCCAATAGATCTCTCCTCGTTGCATCAACAAAATGCCGTACCGCCACGCGTCGCAGAACAACT
CTGCCGTTTACTACGCCTGGCCATCATTTTTGCCAGCCGTCGCCGTGACGATCTCGTGCCAGAGATGACATTAAAGGCCA
ACCATGAACTGTTGACCTTGACGCTTCCGCAAGGTTGGCTAACCCAACATCCGCTGGGTAAAGAGATTATTGATCAGGAA
AGCCAGTGGCAAAGCTATGTTCACTGGCCGTTGGAAGTGCATTAA

Upstream 100 bases:

>100_bases
ATCAAGATGGCAAGAGAGTTAATCCCAATGAGCTTACTGTAGTAAGTGATTCGGATGAAAGAACGCAGCCAACGCAGAGA
CAGATTGAAGGATGAAGAGT

Downstream 100 bases:

>100_bases
AGAGTAATATGCTGGGTGCGATGCTCGCGCATCTTACCCGGCCTTGATTATTTCCCTCGTTTTGCTGCCATCATCGCCTT
CAGATTTGCCAGATGGTTTT

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIR
VVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSL
SMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRF
MIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATL
LLNQTNPIDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLKANHELLTLTLPQGWLTQHPLGKEIIDQE
SQWQSYVHWPLEVH

Sequences:

>Translated_494_residues
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIR
VVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSL
SMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRF
MIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATL
LLNQTNPIDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLKANHELLTLTLPQGWLTQHPLGKEIIDQE
SQWQSYVHWPLEVH
>Mature_493_residues
GSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRV
VATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLS
MGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQ
RAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFM
IDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLL
LNQTNPIDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLKANHELLTLTLPQGWLTQHPLGKEIIDQES
QWQSYVHWPLEVH

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=494, Percent_Identity=99.3927125506073, Blast_Score=1006, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=495, Percent_Identity=38.989898989899, Blast_Score=330, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54930; Mature: 54799

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERG
CCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
WQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLI
HHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHH
YQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQE
HHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEHHHHHHCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
HLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPIDLSSLHQQNAVP
HHHCCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PRVAEQLCRLLRLAIIFASRRRDDLVPEMTLKANHELLTLTLPQGWLTQHPLGKEIIDQE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHCCH
SQWQSYVHWPLEVH
HHHHHHCCCCEEEC
>Mature Secondary Structure 
GSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERG
CCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
WQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLI
HHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHH
YQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQE
HHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEHHHHHHCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
HLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPIDLSSLHQQNAVP
HHHCCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PRVAEQLCRLLRLAIIFASRRRDDLVPEMTLKANHELLTLTLPQGWLTQHPLGKEIIDQE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHCCH
SQWQSYVHWPLEVH
HHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA