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The map label for this gene is yisK [H]

Identifier: 218550944

GI number: 218550944

Start: 3762227

End: 3763081

Strand: Direct

Name: yisK [H]

Synonym: EFER_3670

Alternate gene names: 218550944

Gene position: 3762227-3763081 (Clockwise)

Preceding gene: 218550943

Following gene: 218550946

Centisome position: 81.99

GC content: 46.9

Gene sequence:

>855_bases
ATGAAACTCGTTAGTTTTACCCACAATAACGCCCATCGTTATGGGATCCTCCAGGATAGCGGCGTGACGGATTTAACGCT
GCATTTTCCACAATACCCAACCTTACGGTCATTTCTGGAAGTACTGGAAAATATTCCTCCTTCGACCCTGACCACACTGG
AAATCAACTATCCGCTGGACGACATCACCTTTTTACCGCTGATACCCGATCCGCAAAAAATTCTTTGTGTTGGGATGAAC
TATCAGGAGAAGCGTCTGGAGTTTGATGAAGAAGATCCGGCACCGACGTTGTTTGTGCGTTTCCCTGATTCGCAATGTGG
ACATATGGGAAACATCATCAAACCCGCAGCCAGTCAGGAATTTGACTATGAAGGTGAGCTGGCACTGGTGATTGGAAAAG
GTGGGCGCAATATTTCAGCAGACAATGCACTGCAACATATTGCGGGATATAGCTGCTATATGGATGGCTCTGCCCGTGAC
TGGCAACACGCCTGGTTTACCGCCGGGAAAAACTGGCCCTCAACCGGGGGATTCGGTCCGTGGTTGGTAACGCGTGACGA
AATTAAAGATCCCAATACGCTTTGTATCAAAACGCGTCTTAATGGCGTGGAAGTTCAAAACGAAAACACGATCAATATGA
TACACAGCGTTCCAGAGCTGATTACCTATATCAGCACCTTTTGCCAGTTAGTCCCCGGCGACGTGATTTTAACGGGTTCT
CCTGGCGGGGTTGGGAAGAAACGCACGCCACCGTTATTTTTAAAAGACGGCGATACCATTGAAGTGGAAATCGAAAAGAT
CGGTTGTTTATATAACCGGATTATTGATGAGATTCCTGAAAATATCGCCATTTGA

Upstream 100 bases:

>100_bases
CTGTAATACCCGAACTGCATGGATTGCTGATGACTACCGGGTTTCTGGCCCACCTTCCTGCAGATCTCCTGTTATCTGAT
GATTATCCCGTGAGCTATTA

Downstream 100 bases:

>100_bases
TCAATCACGGAGGCTTTCGCCTCCGTTCTTATTATCATCCCCGACGCAAATTCTGCGCCGCCTGCACCATGTTCGCCAGT
GCCGCGCGGGTTTCTGGCCA

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKLVSFTHNNAHRYGILQDSGVTDLTLHFPQYPTLRSFLEVLENIPPSTLTTLEINYPLDDITFLPLIPDPQKILCVGMN
YQEKRLEFDEEDPAPTLFVRFPDSQCGHMGNIIKPAASQEFDYEGELALVIGKGGRNISADNALQHIAGYSCYMDGSARD
WQHAWFTAGKNWPSTGGFGPWLVTRDEIKDPNTLCIKTRLNGVEVQNENTINMIHSVPELITYISTFCQLVPGDVILTGS
PGGVGKKRTPPLFLKDGDTIEVEIEKIGCLYNRIIDEIPENIAI

Sequences:

>Translated_284_residues
MKLVSFTHNNAHRYGILQDSGVTDLTLHFPQYPTLRSFLEVLENIPPSTLTTLEINYPLDDITFLPLIPDPQKILCVGMN
YQEKRLEFDEEDPAPTLFVRFPDSQCGHMGNIIKPAASQEFDYEGELALVIGKGGRNISADNALQHIAGYSCYMDGSARD
WQHAWFTAGKNWPSTGGFGPWLVTRDEIKDPNTLCIKTRLNGVEVQNENTINMIHSVPELITYISTFCQLVPGDVILTGS
PGGVGKKRTPPLFLKDGDTIEVEIEKIGCLYNRIIDEIPENIAI
>Mature_284_residues
MKLVSFTHNNAHRYGILQDSGVTDLTLHFPQYPTLRSFLEVLENIPPSTLTTLEINYPLDDITFLPLIPDPQKILCVGMN
YQEKRLEFDEEDPAPTLFVRFPDSQCGHMGNIIKPAASQEFDYEGELALVIGKGGRNISADNALQHIAGYSCYMDGSARD
WQHAWFTAGKNWPSTGGFGPWLVTRDEIKDPNTLCIKTRLNGVEVQNENTINMIHSVPELITYISTFCQLVPGDVILTGS
PGGVGKKRTPPLFLKDGDTIEVEIEKIGCLYNRIIDEIPENIAI

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=265, Percent_Identity=40.377358490566, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI40786394, Length=265, Percent_Identity=40, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI215422413, Length=199, Percent_Identity=31.6582914572864, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI13654274, Length=199, Percent_Identity=31.6582914572864, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI66348062, Length=199, Percent_Identity=31.6582914572864, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1787428, Length=200, Percent_Identity=30.5, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17557057, Length=208, Percent_Identity=34.1346153846154, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324161, Length=231, Percent_Identity=25.974025974026, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28572127, Length=294, Percent_Identity=37.4149659863946, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24663695, Length=221, Percent_Identity=38.0090497737557, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28571789, Length=214, Percent_Identity=29.4392523364486, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 31708; Mature: 31708

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVSFTHNNAHRYGILQDSGVTDLTLHFPQYPTLRSFLEVLENIPPSTLTTLEINYPLD
CEEEEEECCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
DITFLPLIPDPQKILCVGMNYQEKRLEFDEEDPAPTLFVRFPDSQCGHMGNIIKPAASQE
CEEEEECCCCCCEEEEECCCCHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
FDYEGELALVIGKGGRNISADNALQHIAGYSCYMDGSARDWQHAWFTAGKNWPSTGGFGP
CCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCC
WLVTRDEIKDPNTLCIKTRLNGVEVQNENTINMIHSVPELITYISTFCQLVPGDVILTGS
EEEEHHHCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
PGGVGKKRTPPLFLKDGDTIEVEIEKIGCLYNRIIDEIPENIAI
CCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLVSFTHNNAHRYGILQDSGVTDLTLHFPQYPTLRSFLEVLENIPPSTLTTLEINYPLD
CEEEEEECCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
DITFLPLIPDPQKILCVGMNYQEKRLEFDEEDPAPTLFVRFPDSQCGHMGNIIKPAASQE
CEEEEECCCCCCEEEEECCCCHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
FDYEGELALVIGKGGRNISADNALQHIAGYSCYMDGSARDWQHAWFTAGKNWPSTGGFGP
CCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCC
WLVTRDEIKDPNTLCIKTRLNGVEVQNENTINMIHSVPELITYISTFCQLVPGDVILTGS
EEEEHHHCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
PGGVGKKRTPPLFLKDGDTIEVEIEKIGCLYNRIIDEIPENIAI
CCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]