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The map label for this gene is yiaY [H]

Identifier: 218550867

GI number: 218550867

Start: 3667869

End: 3669020

Strand: Reverse

Name: yiaY [H]

Synonym: EFER_3583

Alternate gene names: 218550867

Gene position: 3669020-3667869 (Counterclockwise)

Preceding gene: 218550868

Following gene: 218550866

Centisome position: 79.96

GC content: 50.09

Gene sequence:

>1152_bases
ATGGCAGCTTCAACCTTTTTTATTCCTTCTGTGAATGTAATTGGTGCTGATTCATTGAACGACGCAATGAATATGATGGC
GGAATATGGTTTTCGCCGGACATTAATTGTTACTGACAGCATGCTGACTCAATTAGGTATGGCGGGAGATGTACAAAAAG
CATTGCAAGAGCGTGATATTTTCAGCGTTATTTATGATGGTACTCAGCCTAACCCAACGACAGAAAACGTTGCTGCAGGT
CTCAAACTGCTGACCGAAAATAATTGTGATAGCGTAATCTCCCTGGGCGGTGGTTCTCCGCATGACTGCGCAAAAGGTAT
TGCGCTGGTAGCGGCCAACGGTGGTGATATCCGTGATTATGAAGGCGTTGACCGCTCTGCAAAACCGCAGCTGCCGATGA
TCGCCATCAACACCACTGCGGGTACTGCATCAGAAATGACTCGTTTCTGCATCATCACCGACGAAGCACGTCACATCAAA
ATGGCGATTGTTGATAAGCACGTGACTCCGCTGCTTTCTGTCAATGACTCCTCGCTGATGATCGGTATGCCGAAGTCACT
AACCGCCGCCACTGGTATGGATGCTTTAACACACGCTATTGAAGCGTATGTTTCAATTGCTGCAACGCCGATCACTGACG
CTTGCGCACTGAAAGCGGTGACCATGATTGCCGAAAACCTGCCGTTAGCCGTTGAAGATGGCAGCAATGCTAAAGCGCGT
GAAGCAATGGCTTACGCTCAATTCCTCGCTGGTATGGCATTCAACAACGCATCTCTGGGTTATGTTCATGCGATGGCGCA
CCAGCTGGGCGGTTTCTACAACCTGCCACACGGTGTATGTAATGCTGTTCTGCTGCCACACGTTCAGGTGTTCAACAGCA
AAGTCGCTGCTGCGCGTCTGCGTGACTGCGCTGCTGCCATGGGCGTTAACGTGACAGGTAAAAATGACGCAGAAGGTGCA
GAAGCGTGCATCAATGCCATCCGTGAACTGGCGAAGAAAGTGAATATCCCGGCAGGCCTGCGTGACCTGAACGTGAAAGA
AGAAGATATTCCGGTGCTGGCAACCAATGCCCTGAAAGACGCCTGCGGCTTTACTAACCCGATCCAGGCAACTCACGAAG
AAATTATGGCGATTTATCGCGCGGCGATGTAA

Upstream 100 bases:

>100_bases
TTATTCTTCTCATTCCATAAATAACAATGCTGATCATATTTTTGAGTCATACAACCTTGTAAGCTCCCCTTCCTTTATTA
TAAATAATCAGGAGAGTGTT

Downstream 100 bases:

>100_bases
TCATCATTCCCACAATGGCTGGCTAATTGTCAGCCATTTTTTCAACTCTCTCAAAATTTGCGATTTTTGAGAGAGTTTTA
GTTATCTCTGTAATCCTTGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MAASTFFIPSVNVIGADSLNDAMNMMAEYGFRRTLIVTDSMLTQLGMAGDVQKALQERDIFSVIYDGTQPNPTTENVAAG
LKLLTENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIK
MAIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGA
EACINAIRELAKKVNIPAGLRDLNVKEEDIPVLATNALKDACGFTNPIQATHEEIMAIYRAAM

Sequences:

>Translated_383_residues
MAASTFFIPSVNVIGADSLNDAMNMMAEYGFRRTLIVTDSMLTQLGMAGDVQKALQERDIFSVIYDGTQPNPTTENVAAG
LKLLTENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIK
MAIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGA
EACINAIRELAKKVNIPAGLRDLNVKEEDIPVLATNALKDACGFTNPIQATHEEIMAIYRAAM
>Mature_382_residues
AASTFFIPSVNVIGADSLNDAMNMMAEYGFRRTLIVTDSMLTQLGMAGDVQKALQERDIFSVIYDGTQPNPTTENVAAGL
KLLTENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKM
AIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKARE
AMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGAE
ACINAIRELAKKVNIPAGLRDLNVKEEDIPVLATNALKDACGFTNPIQATHEEIMAIYRAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=394, Percent_Identity=24.8730964467005, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI48994951, Length=383, Percent_Identity=96.8668407310705, Blast_Score=760, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=385, Percent_Identity=41.8181818181818, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=37.3015873015873, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1787493, Length=383, Percent_Identity=33.9425587467363, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789386, Length=320, Percent_Identity=26.5625, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=24.4949494949495, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=377, Percent_Identity=55.1724137931034, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24657991, Length=425, Percent_Identity=26.1176470588235, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40403; Mature: 40272

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASTFFIPSVNVIGADSLNDAMNMMAEYGFRRTLIVTDSMLTQLGMAGDVQKALQERDI
CCCCEEECCCCCEECCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCHHHHHHHHHCCC
FSVIYDGTQPNPTTENVAAGLKLLTENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDY
EEEEECCCCCCCCHHHHHHHHHHEECCCCCCEEECCCCCHHHHHCCEEEEEECCCCCCCC
EGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHVTPLLSVNDSSLM
CCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEE
IGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHH
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAAAMGVNVTGKNDAEGAEACINAIRELAKKVNIPAGLRDLNVKEEDIPVLATNALKD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHH
ACGFTNPIQATHEEIMAIYRAAM
HHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AASTFFIPSVNVIGADSLNDAMNMMAEYGFRRTLIVTDSMLTQLGMAGDVQKALQERDI
CCCEEECCCCCEECCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCHHHHHHHHHCCC
FSVIYDGTQPNPTTENVAAGLKLLTENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDY
EEEEECCCCCCCCHHHHHHHHHHEECCCCCCEEECCCCCHHHHHCCEEEEEECCCCCCCC
EGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHVTPLLSVNDSSLM
CCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEE
IGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAR
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHH
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAAAMGVNVTGKNDAEGAEACINAIRELAKKVNIPAGLRDLNVKEEDIPVLATNALKD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHH
ACGFTNPIQATHEEIMAIYRAAM
HHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]