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The map label for this gene is bisC [H]

Identifier: 218550832

GI number: 218550832

Start: 3629118

End: 3631397

Strand: Reverse

Name: bisC [H]

Synonym: EFER_3548

Alternate gene names: 218550832

Gene position: 3631397-3629118 (Counterclockwise)

Preceding gene: 218550839

Following gene: 218550829

Centisome position: 79.14

GC content: 54.43

Gene sequence:

>2280_bases
ATGCTGGTTGAAACTGACGGCGAAACCGTGTTTAGCTCGCGTGGCGCGTTAGCCAGAGGAATGGATAACTCCTTGCAGAG
CGCGGTTCGCGACCAGGTTCACAGCAATACGCGGGTACGATTTCCCATGGTGCGCAAAGGCTTTCTTGCGTCACCGGAAA
ACCCGCAAGGCATTCGTGGGCAGGATGAATTTGTTCGCGTGAGTTGGGATGAGGCGCTGGATCTTATTCACCAACAACAT
AAACGCATTCGTGAGGCTTATGGTCCGGCATCGATTTTTGCGGGTTCCTACGGCTGGCGTTCAAACGGCGTGCTGCATAA
GGCCTCGACATTATTACAACGCTATATGGCGCTGGCGGGTGGATATACCGGGCATCTGGGGGATTATTCGACCGGCGCCG
CACAGGCGATCATGCCGTATGTCGTGGGGGGCAGCGAAGTTTATCAACAGCAGACCAGTTGGCCGCTGGTGCTGGAACAT
AGCGATGTCGTGGTGTTGTGGAGTGCTAACCCTCTCAATACGCTGAAAATTGCGTGGAATGCATCCGATGAGCAGGGGCT
TTCTTACTTTTCCGCACTGCGTGACAGCGGGAAAAAGCTGATCTGCATTGATCCAATGCGATCGGAAACCGTCGATTTCT
TTGGCGATAAAATGGAGTGGGTAGCACCGCATATGGGCACCGATGTTGCTCTGATGCTGGGGATCGCCCATACGCTGGTG
GAAAATGGCTGGCACGACGAAGCGTTTCTGGCGCGTTGCACCACAGGTTATGACGTCTTCTCCTCTTATCTGCTGGGCGA
GAGTGACGGAATAGCGAAAACTGCCGAATGGGCGGCAGAGATTTGTGGGGTTAACGCAGAGAAAATCCGCGAACTGGCGG
CTATTTTCCAGCAAAATACCACCATGCTGATGGCTGGCTGGGGAATGCAGCGCCAACAGTTTGGTGAGCAAAAACACTGG
ATGATCGTCACGCTGGCGGCAATGTTAGGTCAAATAGGTACGCCTGGCGGCGGCTTTGGTCTTTCTTACCATTTTGCCAA
TGGTGGTAACCCCACGCGCCGCGCTGCGGTGCTTTCATCTATGCAGGGCAGCTTGCCAGGTGGCACCGATGCGGTAGATA
AAATCCCCGTAGCCCGTATTGTTGAAGCACTGGAAAACCCTGGCGGCGCGTATCAACATAACGGCATGAACCGCCACTTC
CCGGATATTCGTTTTATCTGGTGGGCGGGCGGCGCCAACTTTACTCATCATCAGGATACCAATCGCCTGATCCGTGCCTG
GCAAAAACCGGAGCTGGTGGTGATCTCCGAGTGCTTCTGGACGGCAGCGGCGAAACACGCCGATATCGTTCTGCCTGCGA
CCACTTCGTTTGAGCGTAATGATCTCACCATGACCGGCGATTACAGTAATCAGCATCTGGTGCCGATGAAGCAAGTGGTG
CCACCACGTGATGAAGCGCGTAATGATTTTGATGTTTTTGCCGGGTTGAGTGAACGCTGGGAGAAGGGCGGCTTTGCGCG
GTTTACGGAAGGGAAAAGTGAGCTGCAATGGCTTGAAACGTTTTATAACGTCGCCCGGCAACGTGGGGCAAGCCAGCAGG
TTGAATTGCCGCCATTTGCTGAGTTCTGGGAAGCCAACCAGTTAATTGAGATGCCGGAACACCCGGACGGTGAGCGGTTT
ATTCGCTTCGCTGATTTTCGCCGCGATCCGCAGGCACATCCATTAAAAACCGTCAGCGGTAAGATTGAAATCTTCTCGCA
GCGTATTGCCGATTACGCTTATCCGGATTGCCCGGGGCATCCGATGTGGCTGGAGCCGGATGAGTGGCAGGGCAATGCCG
AACCAGAACAGTTGCAGGTACTTTCTGCCCATCCGGCGCACCGCTTGCACAGTCAGTTGAATTACAGCTCTCTGCGCGAA
TTATACGCGGTGGCAAACCGCGAACCCATTACCATACATCCTGAAGATGCTCTGGCGCGCGGCATAAAAGAGGGGGATAT
AGTGCGGGTGTGGAACTCCCGTGGGCAGATCCTTGCCGGAGCGGTCATTAGCGAGGGAATTAAACCTGGCGTGATTTGCA
TTCACGAAGGGGCATGGCCGGATCTGGATTTAACCGCTGACGGCATTTGTAAAAACGGCGCAGTGAATGTATTGACTAAA
GACCTCCCCAGCTCGCGGCTGGGGAATGGTTGTGCAGGCAACACGGCTTTGGCGTGGCTGGAAAAATACAACGGTCCTGA
ACTGCCACTTACGGCGTTTGATCCACCTGCCAGCTCATAA

Upstream 100 bases:

>100_bases
TAATATTTAATTGCTCAATACATCTAACCTTTCAGGAGCCTTTGGTTTGGCCAACTCATCCTCACGATATTCCGTTCTGA
CTGCCGCCCACTGGGGGCCC

Downstream 100 bases:

>100_bases
TCCAGGTTGGGTGCTGGGTTTGTTCTTGCCATGCACTGTCAATAACACGGAAACCCTGCGCCATGTAGAAACGCAGTGCT
TGCAGGTTTTCCTGGTAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MLVETDGETVFSSRGALARGMDNSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLARCTTGYDVFSSYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFQQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMNRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRDEARNDFDVFAGLSERWEKGGFARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWEANQLIEMPEHPDGERF
IRFADFRRDPQAHPLKTVSGKIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPITIHPEDALARGIKEGDIVRVWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELPLTAFDPPASS

Sequences:

>Translated_759_residues
MLVETDGETVFSSRGALARGMDNSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLARCTTGYDVFSSYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFQQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMNRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRDEARNDFDVFAGLSERWEKGGFARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWEANQLIEMPEHPDGERF
IRFADFRRDPQAHPLKTVSGKIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPITIHPEDALARGIKEGDIVRVWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELPLTAFDPPASS
>Mature_759_residues
MLVETDGETVFSSRGALARGMDNSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLARCTTGYDVFSSYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFQQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMNRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRDEARNDFDVFAGLSERWEKGGFARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWEANQLIEMPEHPDGERF
IRFADFRRDPQAHPLKTVSGKIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPITIHPEDALARGIKEGDIVRVWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELPLTAFDPPASS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=759, Percent_Identity=96.0474308300395, Blast_Score=1521, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=763, Percent_Identity=64.089121887287, Blast_Score=1046, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=747, Percent_Identity=44.578313253012, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI87081797, Length=757, Percent_Identity=32.6287978863937, Blast_Score=309, Evalue=5e-85,
Organism=Escherichia coli, GI1787870, Length=753, Percent_Identity=30.6772908366534, Blast_Score=292, Evalue=5e-80,
Organism=Escherichia coli, GI171474008, Length=754, Percent_Identity=30.5039787798408, Blast_Score=280, Evalue=3e-76,
Organism=Escherichia coli, GI3868721, Length=473, Percent_Identity=23.6786469344609, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 84057; Mature: 84057

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVETDGETVFSSRGALARGMDNSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRG
CEEECCCCHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCC
QDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAG
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
GYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
CCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEC
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
CCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ENGWHDEAFLARCTTGYDVFSSYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFQQNT
HCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
TMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSS
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
MQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWAGGANFTHHQDT
HCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
HHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHCC
PPRDEARNDFDVFAGLSERWEKGGFARFTEGKSELQWLETFYNVARQRGASQQVELPPFA
CCHHHCCCCHHHHCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EFWEANQLIEMPEHPDGERFIRFADFRRDPQAHPLKTVSGKIEIFSQRIADYAYPDCPGH
HHHCCCCCCCCCCCCCHHHEEEHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCC
PMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPITIHPEDALAR
CCCCCCCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCEEECCHHHHHC
GIKEGDIVRVWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
CCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEC
DLPSSRLGNGCAGNTALAWLEKYNGPELPLTAFDPPASS
CCCHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MLVETDGETVFSSRGALARGMDNSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRG
CEEECCCCHHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCC
QDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAG
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
GYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
CCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEC
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
CCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ENGWHDEAFLARCTTGYDVFSSYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFQQNT
HCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
TMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSS
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
MQGSLPGGTDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWAGGANFTHHQDT
HCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
HHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHCC
PPRDEARNDFDVFAGLSERWEKGGFARFTEGKSELQWLETFYNVARQRGASQQVELPPFA
CCHHHCCCCHHHHCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EFWEANQLIEMPEHPDGERFIRFADFRRDPQAHPLKTVSGKIEIFSQRIADYAYPDCPGH
HHHCCCCCCCCCCCCCHHHEEEHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCC
PMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPITIHPEDALAR
CCCCCCCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCEEECCHHHHHC
GIKEGDIVRVWNSRGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
CCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEC
DLPSSRLGNGCAGNTALAWLEKYNGPELPLTAFDPPASS
CCCHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]