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The map label for this gene is yhiP [H]

Identifier: 218550778

GI number: 218550778

Start: 3566250

End: 3567719

Strand: Direct

Name: yhiP [H]

Synonym: EFER_3489

Alternate gene names: 218550778

Gene position: 3566250-3567719 (Clockwise)

Preceding gene: 218550777

Following gene: 218550781

Centisome position: 77.72

GC content: 49.93

Gene sequence:

>1470_bases
ATGAATACAACAACTCCTACGGGCCTGATGCAGCAACCGCGCCCGTTCTTCATGATTTTCTTTGTTGAGTTATGGGAGCG
CTTTGGCTATTACGGCGTTCAGGGCGTTCTGGCGGTTTTTTTTGTTCAACAACTTGGCTTTTCCCAGGAACAGGCATTTG
TCACCTTCGGCGCATTCGCCGCCCTGGTGTATGGTCTTATCTCGATTGGTGGTTATGTCGGTGACCATCTGTTAGGAACA
AAACGTACCATTGTTTTGGGCGCTATTGTTCTGGCACTCGGTTATTTTATGACCGGGATTTCCCTGCTCAAACCTGACCT
GATTTTTATCGCCCTCGGTACTATCGCAGTGGGTAACGGTTTGTTTAAAGCTAACCCGGCGAGCCTGTTATCGAAATGCT
ATCCGCCAAAAGATCCGCGTCTGGATGGCGCTTTCACGCTGTTTTATATGTCCATAAATATTGGTTCTTTACTGTCGCTG
TCTCTCGCGCCGGTTATTGCTGAGAAATATGGTTATTCCGCAACCTATAACGTATGCGGGGCAGGCTTGATAATCGCTCT
GCTGGTCTATTTTGCTTGCCGTGGGATGGTGAAAAATATTGGTTCTGAGCCAGACTTCTTACCGCTGAGTTTCAGTAAGT
TGCTTTATGTGCTGGTTGGCACGGTCGCGATGGTCTATGTCTGCGCCTGGCTGATGCACAACGTCGAAGTCGCCAATCTG
GTATTGATTGCCCTGTGTATTGTGGTCACCCTTATTTTCTTCCGTCAGGCACTCAAGCTGGATAAAACCGGGCGCAATAA
AATGTTTGTTGCCTTTGTCCTGATGCTCGAAGCGGTGGTGTTTTACATTCTCTACGCCCAAATGCCAACGTCGCTGAACT
TCTTTGCCATCAACAACGTGCATCATGAAATTCTCGGCTTTTCCATCAACCCGGTCAGCTTCCAGGCGCTTAACCCGTTC
TGGGTGGTGGTTGCCAGTCCTGTTCTGGCTGCGATCTATACCCGTCTTGGCAGCAAAGGCAAAGATCTCTCGATGCCGAT
GAAATTTACTCTCGGCATGTTTATGTGCTCGCTGGGCTTTCTTACTGCCGCCGCTGCGGGAATGTGGTTTGCTGATACAC
AAGGGCTGACATCGCCGTGGTTTATCGTGCTGGTTTACTTGTTCCAGAGCCTGGGTGAACTGTTTATTAGCGCCCTGGGG
CTGGCGATGGTTGCCGCTCTGGTGCCGCAGCATTTGATGGGCTTTATTATCGGGATGTGGTTCCTGACGCAGGCTGCCGC
GTTCTTGCTGGGCGGCTATGTGGCAACATTTACCGCAGTACCAGACAATATTACCGATCCACTTGAGACACTGCCCGTCT
ATACCAACGTGTTTGGTAAAATTGGCCTGGTTACACTAGGCGTTGCAGTAATGATGCTGTTGATGGTGCCGTGGCTGAAA
CGCATGATTGAGACGCCGGAAAGCCATTAA

Upstream 100 bases:

>100_bases
ATTCACACATCCAATAACAACAGTCTATAGTAAACGCGACTTTTCGCGCGTTTTGGCTTACGCGTCCATACTTTCTGGAT
GGTTTTGGAAGGCAATAAAT

Downstream 100 bases:

>100_bases
TTATTCTTGCAGAAAACAGGGTAGCAATAACACTACCCTGCTTTACTTTCACACCGGCGTACCTGCATAAATATCAAAGC
GATGTCCTTTGGTAACTACC

Product: inner membrane transporter YhiP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNTTTPTGLMQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVQQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGT
KRTIVLGAIVLALGYFMTGISLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLLSL
SLAPVIAEKYGYSATYNVCGAGLIIALLVYFACRGMVKNIGSEPDFLPLSFSKLLYVLVGTVAMVYVCAWLMHNVEVANL
VLIALCIVVTLIFFRQALKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPF
WVVVASPVLAAIYTRLGSKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADTQGLTSPWFIVLVYLFQSLGELFISALG
LAMVAALVPQHLMGFIIGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVMMLLMVPWLK
RMIETPESH

Sequences:

>Translated_489_residues
MNTTTPTGLMQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVQQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGT
KRTIVLGAIVLALGYFMTGISLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLLSL
SLAPVIAEKYGYSATYNVCGAGLIIALLVYFACRGMVKNIGSEPDFLPLSFSKLLYVLVGTVAMVYVCAWLMHNVEVANL
VLIALCIVVTLIFFRQALKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPF
WVVVASPVLAAIYTRLGSKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADTQGLTSPWFIVLVYLFQSLGELFISALG
LAMVAALVPQHLMGFIIGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVMMLLMVPWLK
RMIETPESH
>Mature_489_residues
MNTTTPTGLMQQPRPFFMIFFVELWERFGYYGVQGVLAVFFVQQLGFSQEQAFVTFGAFAALVYGLISIGGYVGDHLLGT
KRTIVLGAIVLALGYFMTGISLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLLSL
SLAPVIAEKYGYSATYNVCGAGLIIALLVYFACRGMVKNIGSEPDFLPLSFSKLLYVLVGTVAMVYVCAWLMHNVEVANL
VLIALCIVVTLIFFRQALKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPF
WVVVASPVLAAIYTRLGSKGKDLSMPMKFTLGMFMCSLGFLTAAAAGMWFADTQGLTSPWFIVLVYLFQSLGELFISALG
LAMVAALVPQHLMGFIIGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVMMLLMVPWLK
RMIETPESH

Specific function: Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=384, Percent_Identity=23.4375, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI226371746, Length=367, Percent_Identity=26.7029972752044, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789911, Length=489, Percent_Identity=92.4335378323108, Blast_Score=926, Evalue=0.0,
Organism=Escherichia coli, GI1787922, Length=474, Percent_Identity=52.7426160337553, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI1786927, Length=485, Percent_Identity=26.1855670103093, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1790572, Length=486, Percent_Identity=26.7489711934156, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17569141, Length=385, Percent_Identity=25.1948051948052, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541704, Length=384, Percent_Identity=24.21875, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571098, Length=370, Percent_Identity=24.5945945945946, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28571102, Length=370, Percent_Identity=24.5945945945946, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571100, Length=370, Percent_Identity=24.5945945945946, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639583, Length=342, Percent_Identity=24.2690058479532, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639585, Length=331, Percent_Identity=24.4712990936556, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639581, Length=331, Percent_Identity=24.4712990936556, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 53488; Mature: 53488

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS01022 PTR2_1 ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCCC
>Mature Secondary Structure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HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503 [H]