| Definition | Escherichia fergusonii ATCC 35469 chromosome, complete genome. |
|---|---|
| Accession | NC_011740 |
| Length | 4,588,711 |
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The map label for this gene is mrcA [H]
Identifier: 218550652
GI number: 218550652
Start: 3417297
End: 3419849
Strand: Direct
Name: mrcA [H]
Synonym: EFER_3362
Alternate gene names: 218550652
Gene position: 3417297-3419849 (Clockwise)
Preceding gene: 218550631
Following gene: 218550654
Centisome position: 74.47
GC content: 52.29
Gene sequence:
>2553_bases GTGAAGTTCGTAAAGTATTTTTTGATCCTTGCAGTTTGTTGCATTCTGCTGGGAGCAGGCTCGATTTATGGCCTATATCG CTATATCGAGCCACAACTGCCGGATGTCGCGACGCTGAAAGATGTGCGTCTGCAAATCCCAATGCAGGTTTACAGCGCTG ATGGCGAGCTTATCGCGCAATATGGCGAGAAACGTCGTATTCCGGTGACGCTGGATCAGATGCCACCAGAAATGGTCAAA GCCTTTATTGCGACCGAAGACAGCCGATTTTATGAGCATCACGGTGTTGACCCCGTAGGGATCTTCCGTGCCGCCAGCGT TGCGCTGTTTTCTGGTCACGCTTCCCAGGGGGCAAGTACCATTACTCAGCAGCTGGCGAGAAACTTCTTCCTCAGTCCTG AACGCACGCTGATGCGCAAAATCAAAGAAGTTTTTCTTGCCATTCGCATCGAGCAACTGCTGAATAAAGACGAAATCCTT GAGCTTTATCTCAACAAGATTTATCTCGGCTACCGTGCATACGGAGTTGGTGCTGCTGCGCAGGTCTATTTCGGCAAGAC AGTTGATCAGCTGACGTTAAGCGAAATGGCGATGATCGCCGGGTTACCGAAAGCGCCTTCAACCTTTAACCCTCTCTATT CTATGGATCGGGCGCTTGCACGTCGCAATGTTGTGCTGTCGCGTATGTTAAGCGAAGGGTATATCACTCAGCAGCAATAT GATCAGGCGCGGGTAGAGACGATTAATGCAAACTACCACGCACCAGAAATTGCGTTCTCTGCACCCTATCTGACCGAGAT GGTACGTCAGGAGATGTATAACCGTTATGGCGAAAGCGCTTATGAAGACGGTTACCGCATTTACACCACGATTACCCGCA AAGTGCAGCAAGCAGCACAACAGGCAGTGCGTAATAATGTGCTGGACTACGATATGCGTCATGGTTATCGCGGCCCGGCA AACGAGCTGTGGAAAGTGGGGGAAACGGCATGGGATAGCCAAAAAATCACCGATACACTAAAAGCACTGCCGACTTATGG TCCGCTGTTACCCGCTGTAGTAACCAGTGCCAGTGCCCAGGAAGCGTCTGTGATGCTGGCCGATGGCTCATCGGTTACGC TGGGAATGGAAGGTGTACGTTGGGCGCGTCCTTACCGTTCCGATACACAACAAGGCTCCACACCACGTAAAGTGACTGAC GTAGTGCAGGCGGGCCAGCAAATCTGGGTCCGTCAGATGGGCGATGCCTGGTGGCTGGCACAAGTACCGGAAGTTAACTC GGCACTGGTTTCCATTAATCCTCAGAATGGCGCAGTGATGGCACTGGTGGGTGGTTTTGACTTCAACCAGAGCAAGTTTA ACCGCGCAACGCAGGCACTTCGCCAGGTCGGCTCTAATATCAAACCGTTCCTCTATACCGCCGCAATGGATAAAGGCCTG ACGCTGGCAAGTATGTTGAACGACGTCCCAATCTCACGCTGGGATGCAGGTGCCGGATCTGACTGGCAACCGAAAAACTC TCCACCGCAGTATGCCGGTCCAATCCGCTTACGTCAGGGGCTGGGGCAGTCGAAAAACGTGGTGATGGTGCGGGCAATGC GGGCAATGGGCGTGGATTACGCGGCGGAGTATTTACAACGCTTCGGTTTCCCGGCGCAAAACATTGTTCATACTGAATCA CTGGCACTGGGTTCCGCTTCCTTTACGCCGCTGCAGGTAGCTCGTGGTTACGCAGTAATGGCAAATGGCGGCTTCCTGGT CGATCCCTGGTTTATCAGTAAAATTGAGACCGATCAGGCTGGTGTCATTTTCGAAGCAAAACCCAAAATTGCTTGTCCTG AATGCGATATTCCGGTGATTTATGGCGATACGCCAAAGTCGGACGTACTGGAGAACAGCAATGTCGAGGATGTTGCTATC TCCCGGGAGCAGCAAAATTCAACAGTGCCAATGCCGCAACTGGAACAGGCAAATCAGGCATTAGTGGCCGCGACAGGCGC ACAGGAATACGCGCCACATGTGATCAATACTCCGCTGGCCTTTCTGATCAAGAGTGCCCTGAACACCAATATCTTTGGTG AACCTGGCTGGCAGGGTACTGGCTGGCGTGCCGCACGAGATCTTAAACGGCGTGATATCGGCGGAAAAACAGGTACCACT AACAGTTCGAAAGATGCATGGTTCTCAGGTTACGGTCCGGGCGTCGTGACCTCGGTTTGGATTGGCTTTGATGATCACCG CCGTAATCTTGGTCATACAACGGCTTCCGGTGCGATTAAAGATCAGATCTCTGGTTACGAAGGCGGTGCGAAGAGTGCCC AGCCAGCATGGGACGCTTACATGAAAGCCGTGCTTGAAGGTGTGCCAGAACAACCGCTGACACCACCACCGGGTATTGTG ACAGTGAATATTGATCGCAGCACCGGGCAACTGGCAAATGGTGGCAATAGCCGAGAAGAGTATTTCATCGAAGGCACGCA GCCTACACAACATGCGGTGCAAGAGGTGGGAACGACCATTATCGATAATGGCGAGGCTCAGGAATTGTTCTAA
Upstream 100 bases:
>100_bases CCCGTCGCACTGACGGGTATATCAATGCGTCAGGCTTGCCTTTATACTACGGCGCTTTTGTTTATAAACTGCCCAAATGA AACTAAATGGGAAATCTCCA
Downstream 100 bases:
>100_bases TTAAAAAAGGCGCCTCGGCGCCTTTTTTAATGCTAAAGTCGGATACAACACGAACGCCTTCGCATGTCTATAAAATATTT AAATTCAGTGCATTACATGA
Product: peptidoglycan synthetase
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 850; Mature: 850
Protein sequence:
>850_residues MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLDQMPPEMVK AFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEVFLAIRIEQLLNKDEIL ELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAMIAGLPKAPSTFNPLYSMDRALARRNVVLSRMLSEGYITQQQY DQARVETINANYHAPEIAFSAPYLTEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYRGPA NELWKVGETAWDSQKITDTLKALPTYGPLLPAVVTSASAQEASVMLADGSSVTLGMEGVRWARPYRSDTQQGSTPRKVTD VVQAGQQIWVRQMGDAWWLAQVPEVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL TLASMLNDVPISRWDAGAGSDWQPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES LALGSASFTPLQVARGYAVMANGGFLVDPWFISKIETDQAGVIFEAKPKIACPECDIPVIYGDTPKSDVLENSNVEDVAI SREQQNSTVPMPQLEQANQALVAATGAQEYAPHVINTPLAFLIKSALNTNIFGEPGWQGTGWRAARDLKRRDIGGKTGTT NSSKDAWFSGYGPGVVTSVWIGFDDHRRNLGHTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIV TVNIDRSTGQLANGGNSREEYFIEGTQPTQHAVQEVGTTIIDNGEAQELF
Sequences:
>Translated_850_residues MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLDQMPPEMVK AFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEVFLAIRIEQLLNKDEIL ELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAMIAGLPKAPSTFNPLYSMDRALARRNVVLSRMLSEGYITQQQY DQARVETINANYHAPEIAFSAPYLTEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYRGPA NELWKVGETAWDSQKITDTLKALPTYGPLLPAVVTSASAQEASVMLADGSSVTLGMEGVRWARPYRSDTQQGSTPRKVTD VVQAGQQIWVRQMGDAWWLAQVPEVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL TLASMLNDVPISRWDAGAGSDWQPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES LALGSASFTPLQVARGYAVMANGGFLVDPWFISKIETDQAGVIFEAKPKIACPECDIPVIYGDTPKSDVLENSNVEDVAI SREQQNSTVPMPQLEQANQALVAATGAQEYAPHVINTPLAFLIKSALNTNIFGEPGWQGTGWRAARDLKRRDIGGKTGTT NSSKDAWFSGYGPGVVTSVWIGFDDHRRNLGHTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIV TVNIDRSTGQLANGGNSREEYFIEGTQPTQHAVQEVGTTIIDNGEAQELF >Mature_850_residues MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLDQMPPEMVK AFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEVFLAIRIEQLLNKDEIL ELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAMIAGLPKAPSTFNPLYSMDRALARRNVVLSRMLSEGYITQQQY DQARVETINANYHAPEIAFSAPYLTEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYRGPA NELWKVGETAWDSQKITDTLKALPTYGPLLPAVVTSASAQEASVMLADGSSVTLGMEGVRWARPYRSDTQQGSTPRKVTD VVQAGQQIWVRQMGDAWWLAQVPEVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL TLASMLNDVPISRWDAGAGSDWQPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES LALGSASFTPLQVARGYAVMANGGFLVDPWFISKIETDQAGVIFEAKPKIACPECDIPVIYGDTPKSDVLENSNVEDVAI SREQQNSTVPMPQLEQANQALVAATGAQEYAPHVINTPLAFLIKSALNTNIFGEPGWQGTGWRAARDLKRRDIGGKTGTT NSSKDAWFSGYGPGVVTSVWIGFDDHRRNLGHTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIV TVNIDRSTGQLANGGNSREEYFIEGTQPTQHAVQEVGTTIIDNGEAQELF
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=850, Percent_Identity=94.7058823529412, Blast_Score=1680, Evalue=0.0, Organism=Escherichia coli, GI1786343, Length=251, Percent_Identity=35.4581673306773, Blast_Score=143, Evalue=4e-35, Organism=Escherichia coli, GI1788867, Length=261, Percent_Identity=35.2490421455939, Blast_Score=135, Evalue=8e-33, Organism=Escherichia coli, GI1789601, Length=176, Percent_Identity=37.5, Blast_Score=98, Evalue=2e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 93526; Mature: 93526
Theoretical pI: Translated: 6.38; Mature: 6.38
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQ CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHEECCCEEECCCCHHHHH YGEKRRIPVTLDQMPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGAST CCCCCCCCEEHHCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHH ITQQLARNFFLSPERTLMRKIKEVFLAIRIEQLLNKDEILELYLNKIYLGYRAYGVGAAA HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCHH QVYFGKTVDQLTLSEMAMIAGLPKAPSTFNPLYSMDRALARRNVVLSRMLSEGYITQQQY HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH DQARVETINANYHAPEIAFSAPYLTEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQ HHHHHEEECCCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHCCCEEHHHHHHHHHHHHH QAVRNNVLDYDMRHGYRGPANELWKVGETAWDSQKITDTLKALPTYGPLLPAVVTSASAQ HHHHCCCCCHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC EASVMLADGSSVTLGMEGVRWARPYRSDTQQGSTPRKVTDVVQAGQQIWVRQMGDAWWLA CCEEEEECCCEEEEECCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE QVPEVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL ECCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCC TLASMLNDVPISRWDAGAGSDWQPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHCHHH AAEYLQRFGFPAQNIVHTESLALGSASFTPLQVARGYAVMANGGFLVDPWFISKIETDQA HHHHHHHCCCCHHHHEEHHHHCCCCCCCCHHHHHCCEEEEECCCEEECCHHHHEECCCCC GVIFEAKPKIACPECDIPVIYGDTPKSDVLENSNVEDVAISREQQNSTVPMPQLEQANQA CEEEECCCCCCCCCCCCEEEECCCCCHHHHCCCCCCHHEECCHHCCCCCCCCCHHHCCCE LVAATGAQEYAPHVINTPLAFLIKSALNTNIFGEPGWQGTGWRAARDLKRRDIGGKTGTT EEEECCCHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC NSSKDAWFSGYGPGVVTSVWIGFDDHRRNLGHTTASGAIKDQISGYEGGAKSAQPAWDAY CCCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHH MKAVLEGVPEQPLTPPPGIVTVNIDRSTGQLANGGNSREEYFIEGTQPTQHAVQEVGTTI HHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCEE IDNGEAQELF ECCCCHHCCC >Mature Secondary Structure MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQ CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHEECCCEEECCCCHHHHH YGEKRRIPVTLDQMPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGAST CCCCCCCCEEHHCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHH ITQQLARNFFLSPERTLMRKIKEVFLAIRIEQLLNKDEILELYLNKIYLGYRAYGVGAAA HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCHH QVYFGKTVDQLTLSEMAMIAGLPKAPSTFNPLYSMDRALARRNVVLSRMLSEGYITQQQY HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH DQARVETINANYHAPEIAFSAPYLTEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQ HHHHHEEECCCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHCCCEEHHHHHHHHHHHHH QAVRNNVLDYDMRHGYRGPANELWKVGETAWDSQKITDTLKALPTYGPLLPAVVTSASAQ HHHHCCCCCHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC EASVMLADGSSVTLGMEGVRWARPYRSDTQQGSTPRKVTDVVQAGQQIWVRQMGDAWWLA CCEEEEECCCEEEEECCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE QVPEVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL ECCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCC TLASMLNDVPISRWDAGAGSDWQPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHCHHH AAEYLQRFGFPAQNIVHTESLALGSASFTPLQVARGYAVMANGGFLVDPWFISKIETDQA HHHHHHHCCCCHHHHEEHHHHCCCCCCCCHHHHHCCEEEEECCCEEECCHHHHEECCCCC GVIFEAKPKIACPECDIPVIYGDTPKSDVLENSNVEDVAISREQQNSTVPMPQLEQANQA CEEEECCCCCCCCCCCCEEEECCCCCHHHHCCCCCCHHEECCHHCCCCCCCCCHHHCCCE LVAATGAQEYAPHVINTPLAFLIKSALNTNIFGEPGWQGTGWRAARDLKRRDIGGKTGTT EEEECCCHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC NSSKDAWFSGYGPGVVTSVWIGFDDHRRNLGHTTASGAIKDQISGYEGGAKSAQPAWDAY CCCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHH MKAVLEGVPEQPLTPPPGIVTVNIDRSTGQLANGGNSREEYFIEGTQPTQHAVQEVGTTI HHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCEE IDNGEAQELF ECCCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 3882429; 9278503; 3920658; 7006606; 9841666 [H]