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The map label for this gene is acrE [H]

Identifier: 218550549

GI number: 218550549

Start: 3330045

End: 3331202

Strand: Direct

Name: acrE [H]

Synonym: EFER_3244

Alternate gene names: 218550549

Gene position: 3330045-3331202 (Clockwise)

Preceding gene: 218550547

Following gene: 218550550

Centisome position: 72.57

GC content: 50.09

Gene sequence:

>1158_bases
ATGACGAAACATGCCAGGTATTCACTCCTGCCTTCATTCATCATCATCTCTGCCGTGTTACTTGCCGGATGTAAAGAAAA
GGAAGAAACACCAGCGGTACATGCTGAACCACACGTCACAGTACACGTGGTCAAATCAGCACCGCTGGCAGTTACCACCG
AATTACCAGGCCGGACTTCAGCCTTCCGTATTGCAGAAGTTCGTCCGCAAGTGAGCGGCATCATTCTGCAGCGCAATTTT
AAAGAAGGCAGTGATGTTCAGGCAGGTGATTCGCTTTATCAAATTGATCCCGCCACATATCAGGCCAGTTTCGATAGCGC
TAAAGGCGAACTGGCGAAAAGCGAAGCTGCAGCTGCTATCGCACACTTAACAGTGAAACGCTATAACCCACTGGTGGGCA
CCAAATACATCAGCCAACAGGAATACGATCAGGCTATTGCCGACGCCCGTCAGGCTGACGCAGCGGTGATCGCCGCAAAA
GCTGCGGTTGAAAGTGCACGCATTAACCTGGCTTACACCAAAGTGACTTCGCCTATTAGTGGACGTATTGGCAAGTCCAG
CGTCACCGAAGGTGCACTGGTGACCAATGGTCAGGCATCACAACTGGCTACAGTGCAGCAGCTCGATCCAATTTATGTTG
ATGTTACTCAGTCCAGCAATGACTTTATGCGACTGAAACAGTCAGTTGAGTTGGGTAATCTGCATAAAGACAGTGCCAGC
AGCAGTGTCGAACTGGTAATGGAAAATGGCCAGGTTTATCCACTGAAAGGCACGTTGCAATTCTCAGATGTCACCGTTGA
TGAAAGCACCGGCTCCATCACTTTAAGAGCTGTGTTTCCGAATCCACAGCACACCCTCTTGCCTGGTATGTTTGTCCGCG
CACGCATTGACGAAGGCGTACAGCCTGACGCCATTCTTATCCCTCAACAGGGTGTTTCCCGGACACCACGAGGCGATGCT
ACGGTCATGATTGTGAATGACAAAAATCAGGTTGAGGCACGCTCTGTCGAGGCATCTCAAGCCATCGGTGATCAATGGTT
GATCAGCAAAGGATTAAAACAGGGTGAGCAAGTTATCGTTAGCGGCTTACAAAAAGCACGTCCTGGAGCACAGGTTAAAG
CCACTGTGGATACACCCGCTGCCGATGCGTCTAAATAA

Upstream 100 bases:

>100_bases
ATGTTAATTTGTAGGATAGCGGATTGCTATTTTCCATCTTGTGCCTTTGCGCTTTACCGTTCTCCGGTAAATAACGTGCT
TCTGTTTTTAAGGATTAGTA

Downstream 100 bases:

>100_bases
GGTAACCTGATATGGCAAACTTTTTTATTCGACGCCCAATTTTTGCCTGGGTGCTAGCCATCATTTTAATGATGGCTGGT
GTGCTGGCTATTTTACAGTT

Product: cytoplasmic membrane lipoprotein

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTKHARYSLLPSFIIISAVLLAGCKEKEETPAVHAEPHVTVHVVKSAPLAVTTELPGRTSAFRIAEVRPQVSGIILQRNF
KEGSDVQAGDSLYQIDPATYQASFDSAKGELAKSEAAAAIAHLTVKRYNPLVGTKYISQQEYDQAIADARQADAAVIAAK
AAVESARINLAYTKVTSPISGRIGKSSVTEGALVTNGQASQLATVQQLDPIYVDVTQSSNDFMRLKQSVELGNLHKDSAS
SSVELVMENGQVYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDA
TVMIVNDKNQVEARSVEASQAIGDQWLISKGLKQGEQVIVSGLQKARPGAQVKATVDTPAADASK

Sequences:

>Translated_385_residues
MTKHARYSLLPSFIIISAVLLAGCKEKEETPAVHAEPHVTVHVVKSAPLAVTTELPGRTSAFRIAEVRPQVSGIILQRNF
KEGSDVQAGDSLYQIDPATYQASFDSAKGELAKSEAAAAIAHLTVKRYNPLVGTKYISQQEYDQAIADARQADAAVIAAK
AAVESARINLAYTKVTSPISGRIGKSSVTEGALVTNGQASQLATVQQLDPIYVDVTQSSNDFMRLKQSVELGNLHKDSAS
SSVELVMENGQVYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDA
TVMIVNDKNQVEARSVEASQAIGDQWLISKGLKQGEQVIVSGLQKARPGAQVKATVDTPAADASK
>Mature_384_residues
TKHARYSLLPSFIIISAVLLAGCKEKEETPAVHAEPHVTVHVVKSAPLAVTTELPGRTSAFRIAEVRPQVSGIILQRNFK
EGSDVQAGDSLYQIDPATYQASFDSAKGELAKSEAAAAIAHLTVKRYNPLVGTKYISQQEYDQAIADARQADAAVIAAKA
AVESARINLAYTKVTSPISGRIGKSSVTEGALVTNGQASQLATVQQLDPIYVDVTQSSNDFMRLKQSVELGNLHKDSASS
SVELVMENGQVYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDAT
VMIVNDKNQVEARSVEASQAIGDQWLISKGLKQGEQVIVSGLQKARPGAQVKATVDTPAADASK

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=385, Percent_Identity=86.7532467532467, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1786668, Length=375, Percent_Identity=67.7333333333333, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789929, Length=369, Percent_Identity=50.9485094850949, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI87082036, Length=321, Percent_Identity=28.9719626168224, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081951, Length=132, Percent_Identity=32.5757575757576, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41081; Mature: 40950

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHARYSLLPSFIIISAVLLAGCKEKEETPAVHAEPHVTVHVVKSAPLAVTTELPGRTS
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEEECCCEEEEECCCCCCC
AFRIAEVRPQVSGIILQRNFKEGSDVQAGDSLYQIDPATYQASFDSAKGELAKSEAAAAI
EEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
AHLTVKRYNPLVGTKYISQQEYDQAIADARQADAAVIAAKAAVESARINLAYTKVTSPIS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHEEEEEEEEECCCCC
GRIGKSSVTEGALVTNGQASQLATVQQLDPIYVDVTQSSNDFMRLKQSVELGNLHKDSAS
CCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCC
SSVELVMENGQVYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGV
CCEEEEEECCEEEEEECEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEHHCCCC
QPDAILIPQQGVSRTPRGDATVMIVNDKNQVEARSVEASQAIGDQWLISKGLKQGEQVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
SGLQKARPGAQVKATVDTPAADASK
HHHHHCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
TKHARYSLLPSFIIISAVLLAGCKEKEETPAVHAEPHVTVHVVKSAPLAVTTELPGRTS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEEECCCEEEEECCCCCCC
AFRIAEVRPQVSGIILQRNFKEGSDVQAGDSLYQIDPATYQASFDSAKGELAKSEAAAAI
EEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
AHLTVKRYNPLVGTKYISQQEYDQAIADARQADAAVIAAKAAVESARINLAYTKVTSPIS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHEEEEEEEEECCCCC
GRIGKSSVTEGALVTNGQASQLATVQQLDPIYVDVTQSSNDFMRLKQSVELGNLHKDSAS
CCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCC
SSVELVMENGQVYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGV
CCEEEEEECCEEEEEECEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEHHCCCC
QPDAILIPQQGVSRTPRGDATVMIVNDKNQVEARSVEASQAIGDQWLISKGLKQGEQVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
SGLQKARPGAQVKATVDTPAADASK
HHHHHCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]