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The map label for this gene is panF [H]

Identifier: 218550542

GI number: 218550542

Start: 3323785

End: 3325236

Strand: Direct

Name: panF [H]

Synonym: EFER_3237

Alternate gene names: 218550542

Gene position: 3323785-3325236 (Clockwise)

Preceding gene: 218550541

Following gene: 218550543

Centisome position: 72.43

GC content: 54.34

Gene sequence:

>1452_bases
ATGCAGCTTGAAGTGATTCTACCGCTGGTCGCCTATCTGGTGGTGGTGTTCGGGATTTCAGTTTATGCGATGCGTAAACG
GAACACCGGCACCTTCCTTAATGAGTATTTCCTCGGCAGCCGTTCTATGGGCGGTATTGTGCTGGCGATGACGCTCACCG
CGACCTATATCAGTGCCAGTTCGTTTATCGGCGGGCCAGGAGCTGCTTATAAATACGGCCTGGGTTGGGTATTGCTGGCG
ATGATTCAGCTACCTGCGGTCTGGCTTTCGCTCGGTATTCTCGGCAAGAAGTTCGCGATTCTTGCGCGCCGATACAATGC
AGTGACGCTGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTATGGCTGGCGAGTTTGAGTTTGCTGGTTG
CGTTCGTTGGTGCGATGACCGTGCAGTTTATCGGCGGTGCGCGCCTGCTGGAAACCGCGGCGGGTATTCCTTATGAAACC
GGGCTGCTGATTTTCGGTATCAGCATTGCGTTGTATACCGCCTTTGGCGGCTTTCGCGCCAGCGTGCTGAACGACACCAT
GCAAGGGCTGGTGATGCTGATTGGCACCATTGTGCTGCTTATTGGCGTGGTCCATGCTGCTGGCGGCTTAGGCAACGCAG
TAGAGACACTGCAAACCATTGATCCGCAACTGGTTACGCCACAAGGCGCTGACGATATTCTGTCGCCTGCCTTTATGACG
TCGTTCTGGGTGCTGGTGTGCTTTGGCGTTATTGGCCTGCCGCATACTGCGGTGCGCTGTATCTCCTATAAAGACAGCAA
AGCAGTACATCGGGGGATCATCATCGGTACGATTGTAGTCGCAATCCTGATGTTCGGTATGCACCTGGCCGGAGCATTAG
GTCGTGCAGTGATCCCCGATCTCACCGTACCGGACCTGGTGATCCCGACGTTGATGGTAAAAGTATTGCCACCGTTTGCT
GCCGGGATCTTCCTTGCAGCTCCTATGGCTGCGATCATGTCGACGATCAACGCCCAATTGCTGCAAAGTTCCGCTACGAT
CATTAAAGATCTCTATCTGAATATCCGTCCGGATCAAATGCAAAACGAGACGCGCCTGAAGCGGATGTCGGCGGTGATTA
CGTTGATTCTCGGCGCGTTGCTGCTGCTTGCTGCATGGAAGCCGCCTGAAATGATCATCTGGCTGAATTTGCTGGCCTTC
GGCGGGCTGGAAGCTGTCTTCCTGTGGCCGCTGGTACTGGGTCTTTACTGGGAACGCGCTAACGCCAAAGGCGCGCTAAG
TGCGATGATCGTTGGCGGCGTACTGTATGCCGTACTTGCGACACTGAATATTCAGTACCTGGGCTTCCACCCTATCGTGC
CCTCGTTGCTGCTAAGTTTGCTGGCTTTCCTGGTCGGAAACCGTTTCGGTACGTCCGTCCCGCAAGCTACCGTTTTGACT
ACTGATAAATAA

Upstream 100 bases:

>100_bases
TGGTTTGAGATGGCTTGCATCCTGACGCCGCTGCTGTTTATTGGACTGTGCTGGGCGATGGTGAAATTTATCTATCGCGA
TATCCCACTGGAGGATGACG

Downstream 100 bases:

>100_bases
AGAGTTTTGCCATGCCTTGGATCCAACTGAAACTGAACACCACCGGCGCGAACGCCGAAGATCTTAGCGATGCGCTGATG
GAAGCGGGTGCCGTTTCTAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRNTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTIVLLIGVVHAAGGLGNAVETLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLILGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLT
TDK

Sequences:

>Translated_483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRNTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTIVLLIGVVHAAGGLGNAVETLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLILGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLT
TDK
>Mature_483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRNTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTIVLLIGVVHAAGGLGNAVETLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLILGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLT
TDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=27.4841437632135, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=24.4769874476987, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4507033, Length=407, Percent_Identity=26.5356265356265, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=25.0521920668058, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI110835708, Length=500, Percent_Identity=24.2, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507035, Length=396, Percent_Identity=24.4949494949495, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI157671931, Length=359, Percent_Identity=21.4484679665738, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI109659836, Length=495, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=98.9648033126294, Blast_Score=946, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=484, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790113, Length=475, Percent_Identity=23.5789473684211, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790503, Length=492, Percent_Identity=22.1544715447154, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651739, Length=450, Percent_Identity=21.7777777777778, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51744; Mature: 51744

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]