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The map label for this gene is speA [H]

Identifier: 218550186

GI number: 218550186

Start: 2945537

End: 2947513

Strand: Reverse

Name: speA [H]

Synonym: EFER_2878

Alternate gene names: 218550186

Gene position: 2947513-2945537 (Counterclockwise)

Preceding gene: 218550188

Following gene: 218550183

Centisome position: 64.23

GC content: 53.92

Gene sequence:

>1977_bases
ATGTCTGACGACATGTCTATAAGTTTGCCTTCGTCAGCGGGCGAACACGGTGTACTACGCTCCATGCAGGAGGTTGCAAT
GAGCTCCCAGGAAGCCAGCAAGATGCTGCGTACTTACAATATTGCCTGGTGGGGCAATAACTACTATGACGTTAACGAGC
TGGGCCACATTAGCGTGTGCCCGGACCCGGACGTCCCGGAAGCTCGCGTCGATCTCGCGCAGTTAGTGAAAACTCGTGAA
GCACAGGGTCAGCGTCTGCCTGCACTGTTCTGTTTCCCACAGATCCTGCAACACCGTTTGCGTTCCATTAACGCCGCGTT
CAAACGTGCGCGGGAATCCTACGGCTATAACGGCGATTACTTCCTCGTTTATCCGATCAAAGTTAACCAGCACCGCCGCG
TGATTGAGTCCCTGATTCATTCGGGCGAACCACTGGGCCTGGAAGCCGGTTCCAAAGCTGAGTTGATGGCGGTACTGGCG
CATGCTGGCATGACCCGTAGCGTCATCGTCTGCAACGGTTATAAAGACCGCGAATATATCCGCCTGGCATTAATTGGCGA
GAAGATGGGCCATAAGGTCTATCTGGTCATTGAGAAGATGTCAGAAATTGCCATTGTGCTGGATGAAGCAGAACGTCTGA
ATGTCGTTCCTCGTCTGGGCGTGCGCGCGCGTCTGGCGTCTCAAGGTTCTGGCAAATGGCAGTCTTCTGGCGGGGAAAAA
TCGAAGTTCGGCCTGGCGGCGACTCAGGTACTGCAACTGGTTGAAACCCTGCGTGAAGCCGGGCGTCTCGACAGCCTGCA
ATTGTTGCACTTCCACCTTGGTTCGCAGATGGCGAATATTCGCGATATCGCCACGGGCGTTCGTGAATCCGCGCGTTTCT
ATGTTGAGCTGCACAAGCTGGGCGTCAATATTCAGTGCTTTGATGTCGGCGGCGGTCTGGGTGTGGACTATGAAGGTACT
CGTTCGCAGTCCGACTGTTCAGTGAACTACGGCCTCAATGAATACGCCAACAACATCATCTGGGCGATTGGTGATGCGTG
TGAAGAAAATGGTCTGCCGCATCCGACGGTAATCACCGAATCGGGTCGTGCGGTGACTGCGCATCACACCGTGCTGGTGT
CTAATATCATCGGTGTGGAACGTAACGAATACACGGTGCCGACCGCGCCTGCAGAAGACGCGCCGCGCGCATTGCAAAGT
ATGTGGGAAACCTGGCAGGAGATGCACGAACCGGGAACTCGCCGTTCTCTGCGTGAATGGTTACACGACAGCCAGATGGA
TCTGCACGACATTCATATCGGCTACTCTTCCGGCACCTTTAGCCTGCAAGAACGCGCATGGGCTGAGCAGCTTTATTTGA
GCATGTGCCATGAAGTGCAAAAGCAGCTGGATCCGCAAAACCGCGCGCATCGCCCGATTATCGACGAATTGCAGGAACGT
ATGGCGGACAAAATGTACGTCAACTTCTCGCTGTTCCAGTCGATGCCGGACGCATGGGGGATCGACCAGTTGTTCCCGGT
TCTGCCGCTGGAAGGGCTGAATCAAGTTCCGGAGCGCCGCGCCGTGCTACTGGATATTACCTGTGACTCTGACGGTGCTA
TCGATCACTATATCGATGGTGATGGTATTGCCACGACAATGCCAATGCCGGAGTACGATCCGGAGAATCCGCCGATGCTC
GGTTTCTTTATGGTCGGCGCGTATCAGGAAATCCTCGGCAACATGCACAACCTGTTTGGTGATACCGAAGCGGTTGATGT
TTTCGTCTTCCCTGACGGCAGCGTAGAAGTGGAACTGTCTGACGAAGGTGATACCGTGGCGGATATGCTGCAATATGTGC
AGCTCGATCCGAAAACGCTGTTAACCCAGTTCCGCGATCAGGTGAAGAAAACCGATCTTGATGCTGAACTGCAACAACAG
TTCCTGGAAGAGTTCGAGGCAGGTTTGTACGGTTATACTTATCTTGAAGATGAGTAA

Upstream 100 bases:

>100_bases
CGCTGCTGGAAAATCCGTATGCTTATGGGTTGTTATCGCAGTTTCAGGCTGCGATAGTGGTTAACTGTTTTACACTTAAT
AAAATAATTTGAGGTTCGCT

Downstream 100 bases:

>100_bases
TTAAAGCGATGGTTGGGTGTTTTATACAACACCCAACCTTTTCTCAGGTCATAAGGGCCAAAGGAAAGAGCACTAATTGC
GGGAAGAGTACCAGTAAAAT

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSDDMSISLPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAQLVKTRE
AQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLA
HAGMTRSVIVCNGYKDREYIRLALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGT
RSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQS
MWETWQEMHEPGTRRSLREWLHDSQMDLHDIHIGYSSGTFSLQERAWAEQLYLSMCHEVQKQLDPQNRAHRPIIDELQER
MADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLNQVPERRAVLLDITCDSDGAIDHYIDGDGIATTMPMPEYDPENPPML
GFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPKTLLTQFRDQVKKTDLDAELQQQ
FLEEFEAGLYGYTYLEDE

Sequences:

>Translated_658_residues
MSDDMSISLPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAQLVKTRE
AQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLA
HAGMTRSVIVCNGYKDREYIRLALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGT
RSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQS
MWETWQEMHEPGTRRSLREWLHDSQMDLHDIHIGYSSGTFSLQERAWAEQLYLSMCHEVQKQLDPQNRAHRPIIDELQER
MADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLNQVPERRAVLLDITCDSDGAIDHYIDGDGIATTMPMPEYDPENPPML
GFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPKTLLTQFRDQVKKTDLDAELQQQ
FLEEFEAGLYGYTYLEDE
>Mature_657_residues
SDDMSISLPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAQLVKTREA
QGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAH
AGMTRSVIVCNGYKDREYIRLALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEKS
KFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGTR
SQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQSM
WETWQEMHEPGTRRSLREWLHDSQMDLHDIHIGYSSGTFSLQERAWAEQLYLSMCHEVQKQLDPQNRAHRPIIDELQERM
ADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLNQVPERRAVLLDITCDSDGAIDHYIDGDGIATTMPMPEYDPENPPMLG
FFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPKTLLTQFRDQVKKTDLDAELQQQF
LEEFEAGLYGYTYLEDE

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=658, Percent_Identity=99.3920972644377, Blast_Score=1361, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 73898; Mature: 73767

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDMSISLPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVC
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEECCCCCEEEEC
PDPDVPEARVDLAQLVKTREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDY
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
EEEEEEEECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEE
RLALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
EEEEEHHHHCCEEEEEEEHHCCCEEEECCHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
SKFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKL
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHH
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITE
CCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHCCEEEEECCHHHHCCCCCCEEEEC
SGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQSMWETWQEMHEPGTRRSLREW
CCCEEEHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LHDSQMDLHDIHIGYSSGTFSLQERAWAEQLYLSMCHEVQKQLDPQNRAHRPIIDELQER
HCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLNQVPERRAVLLDITCDSDGAIDHYIDG
HHHHHEEEHHHHHCCCCCCCHHHHHHCCCCHHHHCCCCCCEEEEEEEECCCCCEEEEECC
DGIATTMPMPEYDPENPPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELS
CCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEC
DEGDTVADMLQYVQLDPKTLLTQFRDQVKKTDLDAELQQQFLEEFEAGLYGYTYLEDE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
SDDMSISLPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVC
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEECCCCCEEEEC
PDPDVPEARVDLAQLVKTREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDY
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
EEEEEEEECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEE
RLALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
EEEEEHHHHCCEEEEEEEHHCCCEEEECCHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
SKFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKL
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHH
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITE
CCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHCCEEEEECCHHHHCCCCCCEEEEC
SGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQSMWETWQEMHEPGTRRSLREW
CCCEEEHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LHDSQMDLHDIHIGYSSGTFSLQERAWAEQLYLSMCHEVQKQLDPQNRAHRPIIDELQER
HCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MADKMYVNFSLFQSMPDAWGIDQLFPVLPLEGLNQVPERRAVLLDITCDSDGAIDHYIDG
HHHHHEEEHHHHHCCCCCCCHHHHHHCCCCHHHHCCCCCCEEEEEEEECCCCCEEEEECC
DGIATTMPMPEYDPENPPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELS
CCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEC
DEGDTVADMLQYVQLDPKTLLTQFRDQVKKTDLDAELQQQFLEEFEAGLYGYTYLEDE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12384590; 12704152 [H]