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The map label for this gene is aarA [H]

Identifier: 218549768

GI number: 218549768

Start: 2510850

End: 2512787

Strand: Reverse

Name: aarA [H]

Synonym: EFER_2447

Alternate gene names: 218549768

Gene position: 2512787-2510850 (Counterclockwise)

Preceding gene: 218549775

Following gene: 218549767

Centisome position: 54.76

GC content: 49.38

Gene sequence:

>1938_bases
ATGATAACTGCACACGGGAAAAATGCTTTTTTACCTGTCTTTTCAAGGAAGAATCACCTTATGTCCGCATCTTCGGTTAA
GCCGTTAAATGTTCAATTACCCGCAATAACCCTGATCCTTTTTGCGCTATGTGTTGGGATATTTTGTTACCTCGCACAAT
GGATGAGTTATGAAGAAGTCGATCAATCCGCACTCATCCATCTCGGCGCTAACGTTGCCTCTCTCACGTTGTCGGGTGAA
CCCTGGCGCTTATTGAGCAGTGTTTTTCTGCACAGTAGTTTTTCCCATTTGCTGATGAATATGTTTGCACTCCTGGTGGT
GGGGACAGTGGCGGAACGGATACTGGGGAAATGGCGACTCCTGATTATCTGGTTATTCTCCGGCATCTTTGGTGGGCTCA
TCAGCGCCTGTTATGCGTTACGCGAAAGTGAGCAGATAGTCATCAGCGTTGGGGCATCCGGGGCAATTATGGGAATAGCT
GGCGCTGCGATAGCAACACAGCTTTCTTCAGGTGCGGGTACACACCATAAAAACCAGCGGCGAGTATTTTCTCTGTTGGG
TATGGTGGCGCTGACACTGTTGTATGGTGCCCGGCAAGCAGGAATAGATAACGCTTGCCACATTGGCGGCCTGATGGCAG
GTGGGGCGTTGGGTTGGCTGAGTGCGCGTTTATCTTGGCAAAACCGACTTGTTACGGAAGGCGGGATTATTGTTGCGGGT
AGTCTTCTACTGACCGGGGCTATCTGGCTTGTGCAGCAGCAGATTGATGAATCAGTTTTGCAGGTCAGGCAAAGCCTGCG
TGAAGAGTTTTATCCGCAGGAGATTGAACAAGAGCGACGGCATAAAAAGCAGCAGTTAGCGGAGGAACGCAACGCCCTCA
GGGAAACATTACCCGCTCCGGTAAGTCGTGAACAGGCCAGTGGTGATTTGCTCGCTGAGATTGCCGATATCCATGATATG
GCGATCAGTCGGGATGGTAATACGTTATATGCCGCAATTGAAAACACGAACAGTATTGTTGTTTTCGACCTCGGACAAAA
GAAAATCCTGCATACCTTTACAGTGCCCATAGCGAAAGAAAAGTCAGTCAAACATTGTGGTGGCTGTAAAGATCAGGGCG
TCAGATCGCTGGTGTTAAGCCCCGATGAAAAGTTGCTGTATGCGACTTCATTTGAAGCGAATGCAGTATCGGTCATTAAC
GTGGCGACGGGGGAGATTATTCAGTCGATTACCACCGGCGCCCATCCTGACAGCCTTATCCTCTCGCGTGATGGCACAAA
AGCCTGGGTGATGAATCGCACCAGTAATAGTGTGTCAGCGATTGATCTGGTGACTTATCAGCATGTGGCGGATATCCCAC
TGGAGAAATACGACGGGACGGGGACGAGCGGTAAACCAGGCGCCTGGGTTATGGCACTTTCCCCGGATGAAAAAACATTA
CTGGTTCCGGGAGCAGGCAGAGGTAACATCGTGCGGATCAATACCATCACGCATCAGAAAGAAGACTTTCCCGCAGGTGA
TGCGCGTGGTGTCGTTTCTGCGATGGGATTCCGACCAAAAAATGGTGAGGTTATTTTTGCCGATAGTCAGGGGATTTCAC
GTATAAGCACAGGGGATCAACAAGCCAGCATTATGACGCAATGGTGTAGCAGGAGCGTTTATTCTGTTGAGGGTATTAGC
CCGGACGGTCAGTATTTAGCGTTGGTGTCATATGGCCTGCAAGGTTATGTCATCCTGCTCAATATTAATGCCGGGCAGAT
TATTGGCGTTTATCCTGCCAGCTACGTTAATCATCTTCGTTTTTCAGCGGATGGTAGAAAGATATTTGTTATGGCGAAGA
ACGGGTTAATCCAAATGGACAGGACGCGCTCGCTTGATCCGCAGGCAATTATTCGGCATCCCCAATATGGCGATGTGGCT
TGTATCCCTGAACCGTAA

Upstream 100 bases:

>100_bases
CAAAAAATACTTAGGGGTGAATTAATTACGATTGTAATTTCAGGCTGAAAAAGTCATATTTCGGACAGAGTTAACTTTTC
GGTATGGGACGTTTGCCGGG

Downstream 100 bases:

>100_bases
AAAAAAGGGGCATGATAATCACGCCCCACAGCTCAATGAGAAAGTACGTTTTGTTGATACCGGATGCGGTGTGAACAGTT
TATCTGGCCTGCAAAAATGA

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MITAHGKNAFLPVFSRKNHLMSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSGE
PWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIA
GAAIATQLSSGAGTHHKNQRRVFSLLGMVALTLLYGARQAGIDNACHIGGLMAGGALGWLSARLSWQNRLVTEGGIIVAG
SLLLTGAIWLVQQQIDESVLQVRQSLREEFYPQEIEQERRHKKQQLAEERNALRETLPAPVSREQASGDLLAEIADIHDM
AISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTVPIAKEKSVKHCGGCKDQGVRSLVLSPDEKLLYATSFEANAVSVIN
VATGEIIQSITTGAHPDSLILSRDGTKAWVMNRTSNSVSAIDLVTYQHVADIPLEKYDGTGTSGKPGAWVMALSPDEKTL
LVPGAGRGNIVRINTITHQKEDFPAGDARGVVSAMGFRPKNGEVIFADSQGISRISTGDQQASIMTQWCSRSVYSVEGIS
PDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLRFSADGRKIFVMAKNGLIQMDRTRSLDPQAIIRHPQYGDVA
CIPEP

Sequences:

>Translated_645_residues
MITAHGKNAFLPVFSRKNHLMSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSGE
PWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIA
GAAIATQLSSGAGTHHKNQRRVFSLLGMVALTLLYGARQAGIDNACHIGGLMAGGALGWLSARLSWQNRLVTEGGIIVAG
SLLLTGAIWLVQQQIDESVLQVRQSLREEFYPQEIEQERRHKKQQLAEERNALRETLPAPVSREQASGDLLAEIADIHDM
AISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTVPIAKEKSVKHCGGCKDQGVRSLVLSPDEKLLYATSFEANAVSVIN
VATGEIIQSITTGAHPDSLILSRDGTKAWVMNRTSNSVSAIDLVTYQHVADIPLEKYDGTGTSGKPGAWVMALSPDEKTL
LVPGAGRGNIVRINTITHQKEDFPAGDARGVVSAMGFRPKNGEVIFADSQGISRISTGDQQASIMTQWCSRSVYSVEGIS
PDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLRFSADGRKIFVMAKNGLIQMDRTRSLDPQAIIRHPQYGDVA
CIPEP
>Mature_645_residues
MITAHGKNAFLPVFSRKNHLMSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSGE
PWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIA
GAAIATQLSSGAGTHHKNQRRVFSLLGMVALTLLYGARQAGIDNACHIGGLMAGGALGWLSARLSWQNRLVTEGGIIVAG
SLLLTGAIWLVQQQIDESVLQVRQSLREEFYPQEIEQERRHKKQQLAEERNALRETLPAPVSREQASGDLLAEIADIHDM
AISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTVPIAKEKSVKHCGGCKDQGVRSLVLSPDEKLLYATSFEANAVSVIN
VATGEIIQSITTGAHPDSLILSRDGTKAWVMNRTSNSVSAIDLVTYQHVADIPLEKYDGTGTSGKPGAWVMALSPDEKTL
LVPGAGRGNIVRINTITHQKEDFPAGDARGVVSAMGFRPKNGEVIFADSQGISRISTGDQQASIMTQWCSRSVYSVEGIS
PDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLRFSADGRKIFVMAKNGLIQMDRTRSLDPQAIIRHPQYGDVA
CIPEP

Specific function: Rhomboid serine protease that catalyzes intramembrane proteolysis. Mediates quorum-sensing and the subsequent regulation of target genes via activation of the Tat protein export system. Catalyzes the proteolytic activation of tatA by removal of its N- ter

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 69830; Mature: 69830

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITAHGKNAFLPVFSRKNHLMSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEV
CEECCCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DQSALIHLGANVASLTLSGEPWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRL
CCHHHEEECCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIAGAAIATQLSSGAGTHHKNQR
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHH
RVFSLLGMVALTLLYGARQAGIDNACHIGGLMAGGALGWLSARLSWQNRLVTEGGIIVAG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHCCHHHHHHHHHHHHHEEEECCCEEEEC
SLLLTGAIWLVQQQIDESVLQVRQSLREEFYPQEIEQERRHKKQQLAEERNALRETLPAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSREQASGDLLAEIADIHDMAISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTVPIAKE
CCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEEECCCEEEEEECCCCEEEEEEECCCCCC
KSVKHCGGCKDQGVRSLVLSPDEKLLYATSFEANAVSVINVATGEIIQSITTGAHPDSLI
CCCHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCEE
LSRDGTKAWVMNRTSNSVSAIDLVTYQHVADIPLEKYDGTGTSGKPGAWVMALSPDEKTL
EECCCCEEEEEECCCCCCEEEEEEHHHHHHCCCCHHCCCCCCCCCCCEEEEEECCCCCEE
LVPGAGRGNIVRINTITHQKEDFPAGDARGVVSAMGFRPKNGEVIFADSQGISRISTGDQ
EEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCCH
QASIMTQWCSRSVYSVEGISPDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLR
HHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCEEEEEEECCCCCEEEECCHHHHHHEE
FSADGRKIFVMAKNGLIQMDRTRSLDPQAIIRHPQYGDVACIPEP
EECCCCEEEEEECCCEEEECCCCCCCHHHHHCCCCCCCEEECCCC
>Mature Secondary Structure
MITAHGKNAFLPVFSRKNHLMSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEV
CEECCCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DQSALIHLGANVASLTLSGEPWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRL
CCHHHEEECCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIAGAAIATQLSSGAGTHHKNQR
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHH
RVFSLLGMVALTLLYGARQAGIDNACHIGGLMAGGALGWLSARLSWQNRLVTEGGIIVAG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHCCHHHHHHHHHHHHHEEEECCCEEEEC
SLLLTGAIWLVQQQIDESVLQVRQSLREEFYPQEIEQERRHKKQQLAEERNALRETLPAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSREQASGDLLAEIADIHDMAISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTVPIAKE
CCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEEECCCEEEEEECCCCEEEEEEECCCCCC
KSVKHCGGCKDQGVRSLVLSPDEKLLYATSFEANAVSVINVATGEIIQSITTGAHPDSLI
CCCHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCEE
LSRDGTKAWVMNRTSNSVSAIDLVTYQHVADIPLEKYDGTGTSGKPGAWVMALSPDEKTL
EECCCCEEEEEECCCCCCEEEEEEHHHHHHCCCCHHCCCCCCCCCCCEEEEEECCCCCEE
LVPGAGRGNIVRINTITHQKEDFPAGDARGVVSAMGFRPKNGEVIFADSQGISRISTGDQ
EEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCCH
QASIMTQWCSRSVYSVEGISPDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLR
HHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCEEEEEEECCCCCEEEECCHHHHHHEE
FSADGRKIFVMAKNGLIQMDRTRSLDPQAIIRHPQYGDVACIPEP
EECCCCEEEEEECCCEEEECCCCCCCHHHHHCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8051030 [H]