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The map label for this gene is galM [H]

Identifier: 218549677

GI number: 218549677

Start: 2409484

End: 2410524

Strand: Direct

Name: galM [H]

Synonym: EFER_2353

Alternate gene names: 218549677

Gene position: 2409484-2410524 (Clockwise)

Preceding gene: 218549676

Following gene: 218549678

Centisome position: 52.51

GC content: 54.47

Gene sequence:

>1041_bases
GTGCTGAACGAAACTCCCGCACTGGCACCCGATGGTCAGCCGTACCGACTGTTAACTTTGCGTAACAACGCAGGGATGGT
AGTCACGCTGATGGACTGGGGTGCGACTTTACTTTCCGCCCGTATTCCGCTTTCCGATGGCAGCGTCCGCGAGGCGCTGC
TCGGCTGCGCCAGCCCGGAATGCTATCAGGATCAGGCCGCGTTTCTGGGGGCCTCTATTGGTCGTTATGCAAACCGTATC
GCCAATAGTCGTTATACCTTTGACGATGAAACCGTAACACTTTCGCCAAGTCAGGGCGTTAACCAGCTGCACGGCGGCCC
GGAAGGGTTCGACAAACGTCGCTGGCAGATTGTGAATCAGAACGATCGTCAGGTGCTATTTGCCCTGAGTTCAGAAGATG
GCGATCAGGGCTTTCCGGGTAATCTCGGCGCGACAGTGCAGTATCGTCTGACCGACGATAACCGTATCTCCATTACTTAT
CGCGCCACGGTTGATAAACCTTGCCCGGTGAATATGACTAACCACGTCTATTTCAACCTCGACGGCGAGCAGTCTGACGT
ACGCAATCACAAGCTGCAGATTCTGGCAGACGAATATCTGCCGGTTGATGAAGGCGGCATTCCGCACGACGGCCTGAAAT
CTGTCGCCGGAACGTCTTTTGATTTCCGCAGCGCCAAAATCATCGCCAGTGAATTTCTTGCCGACGATGATCAGCGCAAA
GTGAAAGGTTACGATCACGCGTACTTGTTACAGGCTAAAGGTGATGGCAAGAAAGTGGCGGCGCATGTCTGGTCAGCAGA
TGAAAAATTGCAACTGAAGGTCTACACCACCGCTCCGGCTCTGCAATTTTACTCCGGCAACTTCCTTGGTGGCACGCCGT
CACGGGGAACTGAACCTTACGCCGACTGGCAGGGCCTGGCGCTGGAAAGCGAGTTTCTGCCGGACAGCCCAAACCACCCT
GAATGGCCGCAACCGGACTGCTTCCTGCGTCCTGGCGAAGAGTATTCCAGCATGACTGAATATCAGTTTATTGCTGAATA
A

Upstream 100 bases:

>100_bases
TGGTGCCTGCCGTACAGCAGGCTGTCGCTGAACAATATGAAGCAAAAACAGGTATTAAAGAGACTTTTTACGTTTGTAAA
CCATCACAAGGAGCAGGACA

Downstream 100 bases:

>100_bases
CTTTAAGCCCTCGTAATGAGGGCTTTATCCTTATATTGCTCAAATCACCAGCAAACACCGACATATTTGCAACTCAATAT
TCACAACAACCTTACACTGC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRI
ANSRYTFDDETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSEDGDQGFPGNLGATVQYRLTDDNRISITY
RATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAYLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP
EWPQPDCFLRPGEEYSSMTEYQFIAE

Sequences:

>Translated_346_residues
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRI
ANSRYTFDDETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSEDGDQGFPGNLGATVQYRLTDDNRISITY
RATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAYLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP
EWPQPDCFLRPGEEYSSMTEYQFIAE
>Mature_346_residues
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRI
ANSRYTFDDETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSEDGDQGFPGNLGATVQYRLTDDNRISITY
RATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
VKGYDHAYLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHP
EWPQPDCFLRPGEEYSSMTEYQFIAE

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=322, Percent_Identity=36.9565217391304, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1786971, Length=346, Percent_Identity=98.8439306358381, Blast_Score=713, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=32.5227963525836, Blast_Score=190, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=32.5227963525836, Blast_Score=190, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319493, Length=346, Percent_Identity=24.5664739884393, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=27.7310924369748, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324399, Length=352, Percent_Identity=23.8636363636364, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24668278, Length=338, Percent_Identity=33.7278106508876, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24583720, Length=336, Percent_Identity=32.4404761904762, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24659048, Length=342, Percent_Identity=33.9181286549708, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24641876, Length=354, Percent_Identity=27.683615819209, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=27.9411764705882, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38297; Mature: 38297

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEHEEECCCCCCHHHHHHHHCCCCH
CYQDQAAFLGASIGRYANRIANSRYTFDDETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQ
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCHHHHCCCCCCCCCCEEEEECC
NDRQVLFALSSEDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNL
CCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEE
DGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
CCCHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHH
VKGYDHAYLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPY
HCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEECCCCCCCCCCCCCCCC
ADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSMTEYQFIAE
CCCCCEEEECCCCCCCCCCCCCCCCCCEECCCHHHHCCCCEEEECC
>Mature Secondary Structure
MLNETPALAPDGQPYRLLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEHEEECCCCCCHHHHHHHHCCCCH
CYQDQAAFLGASIGRYANRIANSRYTFDDETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQ
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCHHHHCCCCCCCCCCEEEEECC
NDRQVLFALSSEDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNL
CCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEE
DGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRK
CCCHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHH
VKGYDHAYLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPY
HCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCCEEEEECCCCCCCCCCCCCCCC
ADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSMTEYQFIAE
CCCCCEEEECCCCCCCCCCCCCCCCCCEECCCHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]