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The map label for this gene is ybhO [H]

Identifier: 218549644

GI number: 218549644

Start: 2378469

End: 2379710

Strand: Direct

Name: ybhO [H]

Synonym: EFER_2319

Alternate gene names: 218549644

Gene position: 2378469-2379710 (Clockwise)

Preceding gene: 218549643

Following gene: 218549645

Centisome position: 51.83

GC content: 54.03

Gene sequence:

>1242_bases
ATGAAATGTAGCTGGCGCGAAGGCAATAAGATCCAGTTGCTGGAAAACGGCGAGCAATATTATCCCGCGGTGTTTAAGGC
GATTGGCGAGGCACAAGAACGCATCATTCTTGAAACGTTTATCTGGTTTGAGGATGACGTCGGCAAACAGCTGCATGCGG
CACTACTGGCAGCAGCGCAACGCGGGGTAAAAGCGGAAGTCTTGCTGGATGGCTACGGTTCGCCGGATCTCAGCGATGAG
TTTGTCAATGAACTGACGGCAGCTGGCGTGGTGTTCCGCTACTACGATCCCCGCCCTCGCCTTTTTGGTATGCGCACCAA
TGTGTTTCGCCGGATGCATCGCAAAATTGTGGTGATCGACGCACGTATCGCCTTTATTGGTGGGCTGAATTACTCCGCCG
AGCATATGTCCAGCTACGGTCCAGAGGCTAAACAGGATTACGCAGTGCGCCTTGAAGGGCCGATTGTCGAAGATATTCTC
CAGTTTGAACTGGAAAACCTGCCAGGACACAGCGCAGCACGACGCTGGTGGCGACGTCATCACAAAGCGGAAGAAAACCG
CCAGCCGGGAGAAGCGCAGGTATTATTGGTTTGGCGCGATAACGAAGAACATCGTGATGATATCGAACGCCACTATCTGA
AAATGCTCACTCAGGCTCGTCGGGAAGTGATTATCGCCAACGCCTACTTCTTTCCTGGCTATCGATTTTTGCACGCCTTA
CGCAAAGCGGCGCGGCGCGGGGTGCGGATCAAGCTGATCATTCAGGGCGAACCGGATATGCCCATTGTCAGAGTCGGCGC
GCGTTTACTGTACAACTATCTGGTTAAAGGCGGCGTTCAGGTATTTGAGTACCGCCGCCGCCCGCTCCACGGTAAAGTGG
CATTGATGGACGATCACTGGGCGACGGTAGGGTCCAGTAATCTCGATCCGCTCAGTTTGTCGCTAAATCTCGAAGCAAAC
GTCATCATTCACGATCGTAATTTTAACCAGACGCTACGCGATAATCTGAACGGCATCATCGCCGCCGACTGTCAACAAGT
GGATGAATCCATGCTGCCGAAACGCACCTGGTGGAACCTGACCAAAAGCGTGCTGGCATTCCATTTTTTGCGCCACTTCC
CGGCGCTGGTGGGCTGGCTTCCGGCGCACACGCCGCGTCTGGCGCAAGTTGATCCCCCCGCACAACCGACAATGGAAACT
CAGGATCGGATAGAAACTGAAAACACGGGGGTAAAACCCTGA

Upstream 100 bases:

>100_bases
TCTACGTCAAAAATGCCAGCGCCAGCGCGCCAACCGCGTTGCCGCTGCGGACATGGCGACACCTTTCTGATCATGCCCCT
TTAAGTGCGGAGATTCATTT

Downstream 100 bases:

>100_bases
TGAGTAAATCACACCCACGCTGGCGCTTAGCAAAGAAGATCCTCACCTGGCTGTTTTTTATCGCGGTGATAGTGTTGCTG
GTGGTCTACGCCAAAAAAGT

Product: cardiolipin synthase 2

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGHSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRNFNQTLRDNLNGIIAADCQQVDESMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMET
QDRIETENTGVKP

Sequences:

>Translated_413_residues
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGHSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRNFNQTLRDNLNGIIAADCQQVDESMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMET
QDRIETENTGVKP
>Mature_413_residues
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGHSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRNFNQTLRDNLNGIIAADCQQVDESMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMET
QDRIETENTGVKP

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=413, Percent_Identity=99.0314769975787, Blast_Score=848, Evalue=0.0,
Organism=Escherichia coli, GI1787502, Length=400, Percent_Identity=25.25, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87081826, Length=399, Percent_Identity=23.0576441102757, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 47620; Mature: 47620

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCEECHHHHHHHHHCCEEEEEE
ARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGHSAARRWWRRH
EEEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH
HKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
HHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHH
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANVIIHDRNFNQTLRDNLNGIIAADCQQVDESMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRIETENTGVKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCEECHHHHHHHHHCCEEEEEE
ARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGHSAARRWWRRH
EEEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH
HKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
HHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHH
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANVIIHDRNFNQTLRDNLNGIIAADCQQVDESMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRIETENTGVKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]