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The map label for this gene is mlrA [H]

Identifier: 218549541

GI number: 218549541

Start: 2269490

End: 2270221

Strand: Direct

Name: mlrA [H]

Synonym: EFER_2213

Alternate gene names: 218549541

Gene position: 2269490-2270221 (Clockwise)

Preceding gene: 218549537

Following gene: 218549542

Centisome position: 49.46

GC content: 52.32

Gene sequence:

>732_bases
ATGGCGCTTTACACAATTGGTGAAGTGGCGTTGCTTTGTGATATTAACCCTGTGACGTTACGCGCGTGGCAGAGGCGTTA
CGGATTGCTGAAACCGCAGCGGACAGACGGCGGTCATCGCCTGTTTAACGACGCGGATATCGACAGGATCCGGGAGATCA
AACGCTGGATCGACAACGGCGTGCAGGTTAGCAAAGTTAAGATGCTGCTCAGTAATGATAATGTTGATCTACAAAATGGC
TGGCGCGAGCAACAAGAAACGCTACTCAATTACCTGCAAAGTGGCAATCTGCATAGCTTGCGAACATGGATCAAAGAGCG
TGGTCAGGATTACCCCGCCCAGACGCTCACCACGCACCTGTTTATTCCTCTGCGTCGACGACTTCAATGCCAACAACCTA
CTCTCCAGGCATTGCTAGCGATTCTGGACGGCGTGCTGATCAACTACATCGCCATTTGCCTGGCTTCGGCACGTAAAAAA
CAGGGCAAAGAAGCGCTGGTGGTTGGCTGGAATATTCAAGATACCACCCGTCTATGGCTGGAAGGCTGGATCGCCAGTCA
ACAAGGGTGGCGTATTGATGTACTCGCCCATTCCCTCAACCAGCTCCGCCCGGAACTGTTTGAAGGCCGCACGCTATTGG
TGTGGTGCGGTGAAAATCAGACTCCCGCCCAACAGCAACAACTCACCAGTTGGCAGGAACAAGGGCATGATATTTTCCCG
CTTGGCATTTAA

Upstream 100 bases:

>100_bases
TCGATATCAGCCCTTTTTCGATCAAAAAACGATCAGTACTACCTGGTTCGCAAAACTGCGTCTAAAGTTAAACCGGGACC
TCGCGAGCAAAGGTGAGACG

Downstream 100 bases:

>100_bases
TGATTCGTTAACAAATGCGCTTTACTGTACAATCCTTTCGTTAACATAAGGAGTGCATTATGCGCATAGCTAAAATTGGG
GTCATCGCCCTGTTCCTGTT

Product: DNA-binding transcriptional regulator

Products: NA

Alternate protein names: MerR-like regulator A [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNDNVDLQNG
WREQQETLLNYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKK
QGKEALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENQTPAQQQQLTSWQEQGHDIFP
LGI

Sequences:

>Translated_243_residues
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNDNVDLQNG
WREQQETLLNYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKK
QGKEALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENQTPAQQQQLTSWQEQGHDIFP
LGI
>Mature_242_residues
ALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNDNVDLQNGW
REQQETLLNYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQ
GKEALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENQTPAQQQQLTSWQEQGHDIFPL
GI

Specific function: Transcriptional activator of the csg genes required for production of the curli (AgF) [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788448, Length=243, Percent_Identity=97.119341563786, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1787409, Length=239, Percent_Identity=48.9539748953975, Blast_Score=242, Evalue=1e-65,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551 [H]

Pfam domain/function: PF00376 MerR [H]

EC number: NA

Molecular weight: Translated: 28070; Mature: 27938

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNG
CCEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
VQVSKVKMLLSNDNVDLQNGWREQQETLLNYLQSGNLHSLRTWIKERGQDYPAQTLTTHL
CEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
FIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQGKEALVVGWNIQDTTRLWL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
EGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENQTPAQQQQLTSWQEQGHDIFP
HHHHCCCCCCCHHHHHHHHHHHCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEC
LGI
CCC
>Mature Secondary Structure 
ALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNG
CEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
VQVSKVKMLLSNDNVDLQNGWREQQETLLNYLQSGNLHSLRTWIKERGQDYPAQTLTTHL
CEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
FIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQGKEALVVGWNIQDTTRLWL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
EGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENQTPAQQQQLTSWQEQGHDIFP
HHHHCCCCCCCHHHHHHHHHHHCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEC
LGI
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11489123; 9278503 [H]