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The map label for this gene is cpsG [H]

Identifier: 218549445

GI number: 218549445

Start: 2141496

End: 2142863

Strand: Reverse

Name: cpsG [H]

Synonym: EFER_2114

Alternate gene names: 218549445

Gene position: 2142863-2141496 (Counterclockwise)

Preceding gene: 218549446

Following gene: 218549444

Centisome position: 46.7

GC content: 53.07

Gene sequence:

>1368_bases
ATGAAAAAATTAACCTGCTTTAAAGCCTACGATATTCGCGGAAAATTAGGCGAAGAACTGAATGAAGATATCGCCTGGCG
TATTGGGCGTGCCTATGGCGAATTTCTCAAACCGAAAACCATTGTTTTAGGCGGTGATGTCCGTCTCACCAGCGAAACCT
TAAAACTGGCGCTGGCAAAAGGGTTACAGGATGCGGGCGTTGACGTGCTGGATATCGGCATGTCCGGCACTGAAGAGATC
TATTTCGCCACGTTCCATCTCGGTGTGGATGGCGGCATCGAAGTTACCGCCAGCCATAACCCGATGGATTATAACGGCAT
GAAGCTGGTGCGCGAAGGGGCTCGCCCGATCAGCGGTGATACCGGACTGCGCGACGTCCAGCGTCTGGCAGAAGCCAACG
ACTTCCCTCCCGTCGATGAAACCAAACGTGGTCGCTATCAGCAAATCAACCTACGTGACGCATATGTTGATCACCTGTTC
GGTTATATCAATGTCAAAAACCTCACGCCGCTCAAGCTGGTAATCAACTCAGGGAACGGTGCGGCGGGTCCGGTGGTGGA
CGCCATCGAAGCCCGCTTTAAAGCCCTCGGCGCACCCGTGGAATTGATCAAAGTACACAACACGCCGGACGGCAATTTCC
CCAACGGTATTCCTAATCCATTGCTGCCGGAATGCCGCGACGATACCCGCAATGCGGTCATTAAACACGGCGCGGATATG
GGTATTGCTTTTGATGGCGATTTTGACCGCTGTTTCCTGTTTGACGAAAAAGGACAGTTTATCGAGGGCTACTACATTGT
CGGCCTGCTGGCAGAAGCGTTCCTCGAAAAAAATCCCGGCGCGAAGATCATCCACGATCCGCGTCTTTCCTGGAACACCG
TTGATGTAGTGACTGCCGCAGGCGGCACCCCGGTGATGTCGAAAACCGGACACGCCTTTATTAAAGAACGTATGCGCAAG
GAAGACGCCATCTACGGTGGCGAAATGAGCGCCCACCATTACTTCCGTGATTTCGCTTACTGCGACAGCGGCATGATCCC
GTGGCTGCTGGTCGCCGAACTGGTGTGCCTGAAAGGAAAAACGCTGGGCGAACTGGTGCGCGACCGCATGGCTGCATTCC
CGGCAAGCGGTGAGATCAACAGCAAACTGGTGCAACCCGTTGAGGCGATTAATCGCGTCGAACAGCATTTTAGCCGCGAG
GCGCTGGCGGTGGATCGCACCGATGGCATCAGCATGACCTTTGCCGACTGGCGCTTTAACCTGCGTTCCTCCAACACCGA
ACCGGTGGTGCGGTTGAATGTAGAATCGCGTGGCGATATTAAACTCATGATTATGAAAACAGATGAAATATTAAGAATAT
TAAACTAA

Upstream 100 bases:

>100_bases
CGTAATTCCTCTTAATCTTATTGAGGTTAGTTCCGGAGATTATTTAGGTGAGGATGATATTGTTCGTCAAAAAGAACGTT
ACAAAATAGATGACTAATAG

Downstream 100 bases:

>100_bases
CTTTGAGCATAAGGCCATGTTATAAAACATGGTCTTAATTATAATAAATAAACTAAATGGATATTTATATAGGATGAATC
ATAGTGTAGCAATAATAATG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRK
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLVQPVEAINRVEQHFSRE
ALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDIKLMIMKTDEILRILN

Sequences:

>Translated_455_residues
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRK
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLVQPVEAINRVEQHFSRE
ALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDIKLMIMKTDEILRILN
>Mature_455_residues
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRK
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLVQPVEAINRVEQHFSRE
ALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDIKLMIMKTDEILRILN

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=455, Percent_Identity=97.1428571428571, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1789566, Length=452, Percent_Identity=26.5486725663717, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 50393; Mature: 50393

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECHHHHHHHHHH
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGD
CHHHCCCCEEEECCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHCCCCCCCC
TGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINVKNLTPLKLVINSGNG
CCHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHEEEECCCCEEEEEEECCCC
AAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
CCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAA
EEEECCCCCEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEC
GGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGK
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
TLGELVRDRMAAFPASGEINSKLVQPVEAINRVEQHFSREALAVDRTDGISMTFADWRFN
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCEEEEEEEEEE
LRSSNTEPVVRLNVESRGDIKLMIMKTDEILRILN
ECCCCCCCEEEEEECCCCCEEEEEECCHHHHHHCC
>Mature Secondary Structure
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECHHHHHHHHHH
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARPISGD
CHHHCCCCEEEECCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHCCCCCCCC
TGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINVKNLTPLKLVINSGNG
CCHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHEEEECCCCEEEEEEECCCC
AAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
CCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTVDVVTAA
EEEECCCCCEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEC
GGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGK
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
TLGELVRDRMAAFPASGEINSKLVQPVEAINRVEQHFSREALAVDRTDGISMTFADWRFN
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCEEEEEEEEEE
LRSSNTEPVVRLNVESRGDIKLMIMKTDEILRILN
ECCCCCCCEEEEEECCCCCEEEEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9673232; 10222209; 11206551; 11258796 [H]