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The map label for this gene is gnd [H]

Identifier: 218549443

GI number: 218549443

Start: 2137769

End: 2139175

Strand: Reverse

Name: gnd [H]

Synonym: EFER_2112

Alternate gene names: 218549443

Gene position: 2139175-2137769 (Counterclockwise)

Preceding gene: 218549444

Following gene: 218549442

Centisome position: 46.62

GC content: 50.32

Gene sequence:

>1407_bases
ATGTCAAAGCAACAGATCGGCGTCGTCGGTATGGCAGTTATGGGGCGCAACCTTGCGCTCAACATCGAAAGCCGTGGTTA
TACCGTCTCTATTTTCAACCGTTCCCGTGAAAAGACGGAAGAAGTGATTACCGAAAATCCAGGCAAGAAACTGGTTCCTT
ACTATACGGTGAAAGAGTTTGTTGAATCTCTGGAAACGCCTCGTCGTATCCTGTTAATGGTGAAAGCAGGTGCAGGGACG
GATGCTACTATTGATTCCCTTAAACCATATCTCGATAAAGGTGACATCATCATTGATGGCGGTAACACCTTCTTCCAGGA
CACCATTCGTCGTAACCGTGAGCTTTCTGCAGAAGGCTTTAACTTTATCGGTACTGGTGTTTCCGGTGGTGAAGAGGGCG
CGCTGAAAGGTCCTTCCATTATGCCTGGTGGCCAGAAAGAAGCCTATGAACTGGTTGCGCCGATCCTGACCAAAATCGCC
GCAGTAGCTGAAGACGGTGAGCCATGCGTTACCTATATTGGTGCCGATGGCGCAGGTCACTATGTGAAGATGGTTCACAA
CGGTATTGAATACGGTGATATGCAGCTGATTGCTGAAGCCTATTCTCTGCTTAAAGGTGGCCTGAACCTCACCAACGAAG
AACTGGCGCAGACCTTTACCGAGTGGAATAACGGTGAACTGAGCAGCTACCTGATCGACATCACCAAAGATATCTTCACC
AAAAAAGATGAAGACGGTAACTACCTGGTTGATGTGATTCTGGATGAAGCAGCAAACAAAGGTACCGGTAAATGGACCAG
CCAGAGCGCGCTGGATCTCGGCGAACCACTGTCGCTGATTACCGAGTCTGTGTTTGCACGTTATATCTCTTCTCTGAAAG
ATCAGCGTGTTGCCGCATCTAAAGTTCTCTCTGGCCCGCAAGCACAGGCAGCTGGCGACAAGGCTGAGTTTATCGAGAAA
GTTCGTCGTGCGCTGTATCTGGGCAAAATCGTTTCTTACGCTCAGGGCTTCTCTCAGCTGCGTGCGGCGTCTGAAGAGTA
CAACTGGGATCTGAACTACGGCGAAATCGCGAAGATTTTCCGTGCTGGCTGCATCATCCGTGCGCAGTTCCTGCAGAAAA
TCACCGATGCATATGCCGAAAATCCGCAGATCGCTAACCTGCTGCTGGCCCCGTACTTCAAGCAAATCGCCGATGACTAC
CAGCAGGCGCTGCGTGATGTCGTTGCTTATGCGGTACTGAACGGTATCCCGGTTCCTACCTTCGCTGCTGCGGTTGCCTA
TTACGACAGCTACCGTGCCGCTGTTCTGCCTGCGAATCTGATCCAGGCACAGCGTGACTATTTCGGTGCACATACTTATA
AGCGCATCGATAAAGAAGGTGTGTTCCATACCGAATGGCTGGATTAA

Upstream 100 bases:

>100_bases
CTGGTGTACTTATATTGTTTATTATCTAATATGAGTTAACATCAGAATCAGCTTATAGCTGCATAAGAATTATGGTGACT
ACCCCTGACAGGAGTAAACA

Downstream 100 bases:

>100_bases
TCTGATTTAAATCAATTAATCAATGCAAGGCCCGGAGAAACCCTCCGGGCTTTTTTATTATACAAAGCGGCAGGTTATGG
CCTTTTTTTATAATTTATGG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVITENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGT
DATIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFT
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQAAGDKAEFIEK
VRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDY
QQALRDVVAYAVLNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD

Sequences:

>Translated_468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVITENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGT
DATIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFT
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQAAGDKAEFIEK
VRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDY
QQALRDVVAYAVLNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD
>Mature_467_residues
SKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVITENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTD
ATIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAA
VAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTK
KDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQAAGDKAEFIEKV
RRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQ
QALRDVVAYAVLNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=469, Percent_Identity=53.7313432835821, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=98.9316239316239, Blast_Score=948, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=49.8938428874735, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=50.3267973856209, Blast_Score=470, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=50.4424778761062, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=51.063829787234, Blast_Score=459, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51485; Mature: 51354

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVITENPGKKLVPYYTVKEF
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VESLETPRRILLMVKAGAGTDATIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGF
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAEDGEPCVTYIGADGAGH
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
YVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFT
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAAS
CCCCCCCEEEEEEEHHHCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVLSGPQAQAAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIF
HHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYAVLNGIPVPT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
FAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD
HHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVITENPGKKLVPYYTVKEF
CCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VESLETPRRILLMVKAGAGTDATIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGF
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAEDGEPCVTYIGADGAGH
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
YVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFT
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAAS
CCCCCCCEEEEEEEHHHCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVLSGPQAQAAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIF
HHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADDYQQALRDVVAYAVLNGIPVPT
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
FAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWLD
HHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]