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The map label for this gene is fnr [H]

Identifier: 218548992

GI number: 218548992

Start: 1685737

End: 1686489

Strand: Direct

Name: fnr [H]

Synonym: EFER_1640

Alternate gene names: 218548992

Gene position: 1685737-1686489 (Clockwise)

Preceding gene: 218548991

Following gene: 218548994

Centisome position: 36.74

GC content: 50.07

Gene sequence:

>753_bases
ATGATCCCGGAAAAGCGAATTATACGGCGCATTCAGTCTGGCGGTTGTGCTATCCATTGCCAGGATTGCAGCATCAGCCA
GCTTTGCATCCCGTTCACACTTAACGAGCATGAGCTTGATCAGCTTGATAACATCATCGAGCGTAAAAAGCCCATTCAGA
AAGGCCAGACACTGTTTAAAGCTGGCGATGAACTGAAATCGCTCTACGCCATCCGATCCGGCACGATTAAAAGCTATACC
ATTACCGAACAAGGCGATGAACAGATCACCGGTTTCCATTTAGCAGGCGATCTGGTCGGTTTTGATGCCATCGGCACTGG
ACATCATCCGAGTTTCGCCCAGGCGCTGGAAACCTCGATGGTATGCGAAATCCCGTTTGAAACACTGGACGATCTGTCCG
GGAAAATGCCGAATCTGCGTCAGCAGATGATGCGCCTGATGAGCGGTGAGATCAAAGGCGACCAGGATATGATCCTGTTG
TTGTCGAAGAAAAATGCCGAAGAACGTCTGGCGGCGTTTATATACAATCTTTCCCGTCGTTTCGCCCAGCGTGGTTTCTC
TCCTCGCGAATTCCGTTTGACGATGACGCGTGGTGATATCGGTAACTATCTGGGGCTGACCGTTGAAACTATCAGCCGTT
TGCTGGGGCGTTTCCAGAAAAGTGGTATGCTGGCAGTAAAAGGCAAATACATCACCATTGAAAATAACGATGCGCTGGCA
CAACTTGCCGGTCATACACGCAACGTTGCCTGA

Upstream 100 bases:

>100_bases
CAAATATAAGAATAATCCGCTATTGAAGGATTTGCGCCCTTACGTGCTCACCAAAAAGATGTTAAAATTGACAAATATCA
ATTACGGCTTGAGCAGACCT

Downstream 100 bases:

>100_bases
TTAATCCACAAACCTTCCGTTATGTTTCTGTCAGATCGATAAATTATTTGTATTTATTGATCTGACAGAAGATTCCCCCC
TGTTTCAGGGGTCTGACGCT

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGTGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALA
QLAGHTRNVA

Sequences:

>Translated_250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGTGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALA
QLAGHTRNVA
>Mature_250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGTGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALA
QLAGHTRNVA

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=250, Percent_Identity=99.6, Blast_Score=514, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27982; Mature: 27982

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGTGHHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHCCCCCCCCCCCHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECEEEEEECCCHHH
QLAGHTRNVA
HHHCCCCCCC
>Mature Secondary Structure
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGTGHHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHCCCCCCCCCCCHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENNDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECEEEEEECCCHHH
QLAGHTRNVA
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]