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The map label for this gene is slrP [H]

Identifier: 218548480

GI number: 218548480

Start: 1152124

End: 1152885

Strand: Direct

Name: slrP [H]

Synonym: EFER_1108

Alternate gene names: 218548480

Gene position: 1152124-1152885 (Clockwise)

Preceding gene: 218548477

Following gene: 218548482

Centisome position: 25.11

GC content: 35.56

Gene sequence:

>762_bases
TTGACAATGGAAGCCGGAAAGATGACAACAGGAATAAATAATACACATCAACCCTCAGCCGAAGATTTTAATAACTTTTC
CGAAAGTGTGATTTTATATATAAAAAACAAACGTGATGAGATAATTAAGGACGAAAGGCCAGTTTTGAAATTTTTGGAAT
CTTGCTGGCAGAGTGATACACAACAATTCAGAAATAACGAATATGTTATTAATATCACCCAGAATATTTCTTTGTTGCTT
AGTCAGGGAAATAACAGTAATTCACAAAAAATAAATATTGATAAACCGGAGTTGGTGAATAGCTTTCGACAGGCCATCAT
TGACACTATCAATTGGCGTATTCTGAACACATGGTATGAATGGGCAAAGGACAGAACTTTGGATGAGAAAAGGTCTGAAG
CCCTTGCCAGAGTAACAAGATGTCTGAACCATAGTGATACTCGACTGGATTTGAGTCATCTGTGTCTGACGACCATTCCT
GATGATTTACCTGCCAGTATTACGTATTTAAAACTTCATGGTAACAGACTGGAGCATTTACCTTCGCGCTTACCTTTCGG
ATTAGTCAATTTATATCTCAATGATAATAATTTAAAAGATATGCCAGATAATTTACCCGTTACACTCAAGTTACTTAATA
TTAGTCATAATCCGTTGAAAATCACGTCAGAACAAAGCAGACAGTATCAATCCCTCCTCAAGATATTTAGTTTCCAACCT
GAACAGATCAGAGAAGAAGAAACCGTTGAATATTATTTCTAA

Upstream 100 bases:

>100_bases
TTCTGATCTCTTAAACCCTGATTTTTCTTTCTTCTCTATAATTGAGCGATTTTTGATATTTTTTCCTTTCACTTAGGTTA
ATGATATATCCTACCCGTCA

Downstream 100 bases:

>100_bases
TCCTGATTAACACCCCTTGAGATTTATTTGACAGGGGTGACGCTTGCCAATGTTATCGTTAGTGCAATGGAGATTACGGT
CCTAAATATAGCGTAAATGG

Product: hypothetical protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTMEAGKMTTGINNTHQPSAEDFNNFSESVILYIKNKRDEIIKDERPVLKFLESCWQSDTQQFRNNEYVINITQNISLLL
SQGNNSNSQKINIDKPELVNSFRQAIIDTINWRILNTWYEWAKDRTLDEKRSEALARVTRCLNHSDTRLDLSHLCLTTIP
DDLPASITYLKLHGNRLEHLPSRLPFGLVNLYLNDNNLKDMPDNLPVTLKLLNISHNPLKITSEQSRQYQSLLKIFSFQP
EQIREEETVEYYF

Sequences:

>Translated_253_residues
MTMEAGKMTTGINNTHQPSAEDFNNFSESVILYIKNKRDEIIKDERPVLKFLESCWQSDTQQFRNNEYVINITQNISLLL
SQGNNSNSQKINIDKPELVNSFRQAIIDTINWRILNTWYEWAKDRTLDEKRSEALARVTRCLNHSDTRLDLSHLCLTTIP
DDLPASITYLKLHGNRLEHLPSRLPFGLVNLYLNDNNLKDMPDNLPVTLKLLNISHNPLKITSEQSRQYQSLLKIFSFQP
EQIREEETVEYYF
>Mature_252_residues
TMEAGKMTTGINNTHQPSAEDFNNFSESVILYIKNKRDEIIKDERPVLKFLESCWQSDTQQFRNNEYVINITQNISLLLS
QGNNSNSQKINIDKPELVNSFRQAIIDTINWRILNTWYEWAKDRTLDEKRSEALARVTRCLNHSDTRLDLSHLCLTTIPD
DLPASITYLKLHGNRLEHLPSRLPFGLVNLYLNDNNLKDMPDNLPVTLKLLNISHNPLKITSEQSRQYQSLLKIFSFQPE
QIREEETVEYYF

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 29589; Mature: 29458

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMEAGKMTTGINNTHQPSAEDFNNFSESVILYIKNKRDEIIKDERPVLKFLESCWQSDT
CCCCCCCEECCCCCCCCCCHHHHHCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHH
QQFRNNEYVINITQNISLLLSQGNNSNSQKINIDKPELVNSFRQAIIDTINWRILNTWYE
HHHCCCCEEEEEECCEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHEEHHHHHH
WAKDRTLDEKRSEALARVTRCLNHSDTRLDLSHLCLTTIPDDLPASITYLKLHGNRLEHL
HHHCCCHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCCCCCCEEEEEECCCHHHHH
PSRLPFGLVNLYLNDNNLKDMPDNLPVTLKLLNISHNPLKITSEQSRQYQSLLKIFSFQP
HHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHCCCH
EQIREEETVEYYF
HHHCCCCCCEECC
>Mature Secondary Structure 
TMEAGKMTTGINNTHQPSAEDFNNFSESVILYIKNKRDEIIKDERPVLKFLESCWQSDT
CCCCCCEECCCCCCCCCCHHHHHCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHH
QQFRNNEYVINITQNISLLLSQGNNSNSQKINIDKPELVNSFRQAIIDTINWRILNTWYE
HHHCCCCEEEEEECCEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHEEHHHHHH
WAKDRTLDEKRSEALARVTRCLNHSDTRLDLSHLCLTTIPDDLPASITYLKLHGNRLEHL
HHHCCCHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCCCCCCEEEEEECCCHHHHH
PSRLPFGLVNLYLNDNNLKDMPDNLPVTLKLLNISHNPLKITSEQSRQYQSLLKIFSFQP
HHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHCCCH
EQIREEETVEYYF
HHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]