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The map label for this gene is pdxK [H]

Identifier: 218548141

GI number: 218548141

Start: 770690

End: 771541

Strand: Direct

Name: pdxK [H]

Synonym: EFER_0754

Alternate gene names: 218548141

Gene position: 770690-771541 (Clockwise)

Preceding gene: 218548139

Following gene: 218548147

Centisome position: 16.8

GC content: 50.94

Gene sequence:

>852_bases
ATGAGTAGTTTGTTGTTGTTTAACGATAAGAGCAGGGCATTGCAGGCGGATATCGTCGCCGTGCAGTCGCAGGTAGTGTA
CGGCAGCGTAGGCAACAGCATTGCCGTGCCTGCTATTAAACAGAACGGCCTGAATGTCTTTGCCGTGCCGACGGTATTGC
TGAGCAATACGCCGCATTATGACACGTTCTACGGCGGTGCGATTCCGGACGAATGGTTTAGCGGCTATTTGCGTGCGCTT
CAGGAGCGCGATGCGCTGCGCCAGCTGCGCGCTGTCACCACGGGCTATATGGGAACGGCATCGCAAATCAAAATCCTTGC
CGAGTGGCTGACTGCGCTACGCAAAGACCATCCTGACTTATTGATTATGGTCGATCCGGTGATTGGCGATATTGATAGCG
GAATTTATGTCAAACCTGATCTTCCTGAGGCATACCGACAATATTTACTGCCTCTGGCGCAGGGTATTACGCCTAATATC
TTTGAGCTGGAAATCCTGACAGGTAAAAATTGCCGCGATCTCGACAGCGCCATTGCTGCCGCAAAAAGTCTGCTTTCAGA
CACATTAAAGTGGGTGGTGATTACCAGTGCCTCCGGTAATGAAGAAAATCAGGAGATGCAGGTGGTGGTGGTCAGCGCCG
ACAGCGTGAATGTCATTTCCCATTCACGGGTTAAAACTGACCTGAAAGGTACTGGCGACCTGTTTTGTGCTCAGCTTATC
AGTGGCTTGTTGAAAGGTAAGGAATTAACTGACGCGGTACATAGCGCGGGATTACGCGTGCTGGAGGTGATGCGCTATAC
CCAGCAGTATGATAGCGATGAATTAATTTTGCCGCCGCTGGCTGAAGCATAA

Upstream 100 bases:

>100_bases
TTACCTTATCCTTGTGTGGTGATAGCCGATTTGACTGCCAGAATCAGGTAAAGTTTCGGTTGGAATACGATGAGGATCAT
CGGCAAGGAGAAAAAATTAA

Downstream 100 bases:

>100_bases
AAAAAATGGCGCCGATGGGCGCCATTTTTCTCTGCGACAAGAATTACTTCTTGATGCGGATAACCGGGGTTTCACCCACA
GTCACGCTACCGGACAGTTT

Product: pyridoxal kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRAL
QERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNI
FELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLI
SGLLKGKELTDAVHSAGLRVLEVMRYTQQYDSDELILPPLAEA

Sequences:

>Translated_283_residues
MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRAL
QERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNI
FELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLI
SGLLKGKELTDAVHSAGLRVLEVMRYTQQYDSDELILPPLAEA
>Mature_282_residues
SSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQ
ERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIF
ELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLIS
GLLKGKELTDAVHSAGLRVLEVMRYTQQYDSDELILPPLAEA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=241, Percent_Identity=27.8008298755187, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788758, Length=283, Percent_Identity=97.8798586572438, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1787924, Length=266, Percent_Identity=28.9473684210526, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17507759, Length=268, Percent_Identity=29.4776119402985, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17507757, Length=278, Percent_Identity=28.4172661870504, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320806, Length=273, Percent_Identity=25.6410256410256, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324354, Length=253, Percent_Identity=27.6679841897233, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45553007, Length=188, Percent_Identity=34.0425531914894, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 30849; Mature: 30717

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHY
CCCEEEECCCCHHHHHHHHHHHHHHEEECCCCCEECCCCCCCCCEEEEEHHHHHCCCCCC
DTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCE
LIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAA
EEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
AKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLI
HHHHHHHCEEEEEEECCCCCCCCCEEEEEEEECCCEEEHHHHHHHCCCCCCHHHHHHHHH
SGLLKGKELTDAVHSAGLRVLEVMRYTQQYDSDELILPPLAEA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
SSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHY
CCEEEECCCCHHHHHHHHHHHHHHEEECCCCCEECCCCCCCCCEEEEEHHHHHCCCCCC
DTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCE
LIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAA
EEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
AKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLI
HHHHHHHCEEEEEEECCCCCCCCCEEEEEEEECCCEEEHHHHHHHCCCCCCHHHHHHHHH
SGLLKGKELTDAVHSAGLRVLEVMRYTQQYDSDELILPPLAEA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA