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The map label for this gene is yfhK [H]

Identifier: 218547917

GI number: 218547917

Start: 520482

End: 521909

Strand: Direct

Name: yfhK [H]

Synonym: EFER_0519

Alternate gene names: 218547917

Gene position: 520482-521909 (Clockwise)

Preceding gene: 218547916

Following gene: 218547918

Centisome position: 11.34

GC content: 52.94

Gene sequence:

>1428_bases
TTGAAACGCTGGCCCGTTTTTCCCCGCTCATTACGACAACTGGTAATGCTGGCATTTTTGCTGATTCTGCTGCCCCTGTT
GGTGCTGGCATGGCAAGCCTGGCAAAGCCTGAATGCGCTTAGCGATCAGGCGGCGCTGGTTAACCGCACTACGCTTATTG
ATGCCAGACGTAGTGAAGCGATGACCAACGCGGCGCTGGAGATGGAGCGTAGCTACCGTCAGTATTGCGTGCTGGACGAC
CCAACTCTGGCGAAGGTTTATCAAAGCCAGCGCAAGCGTTACAGCGAAATGCTCGATGCCCACGCAGGCGTACTGCCGAA
CGATAAACTCTACCAGGCATTACGTCAGGATTTGAACAATCTGGCTCAACTTCAGTGTAACAACAGCGGTCCCGATGCTG
CTGCCGCCGCGCGTCTTGAAGCCTTTGCCAGTGCCAATACCGAAATAGTACAGGCCACGCGCACAGTGGTGTTCTCTCGC
GGACAGCAGCTTCAGCGTGAAATCGCCGAACGTGGGCAATATTTTGGTTGGCAATCGCTGGTGTTATTTCTGGTAAGTCT
GGTGATGGTGCTGCTCTTCACGCGGATGATTATCGGCCCGGTGAAAAATATTGAACGGATGATCAACCGTCTGGGGGAAG
GGCGTTCTCTGGGCAATAGCGTTTCGTTCAGTGGGCCGAGTGAGTTACGCTCGGTTGGGCAACGTATTCTTTGGTTAAGT
GAGCGCCTGTCATGGTTGGAATCCCAGCGCCATCAATTCTTAAGACATTTATCTCATGAATTAAAAACCCCGCTGGCGAG
TATGCGCGAGGGCACTGAATTACTGGCTGACCAGGTTGTCGGGCCGCTTACGCCCGAGCAAAAAGAGGTGGTGAGCATCC
TTGATAGCAGCAGCCGCAATTTGCAAAAACTGATCGAACAACTGCTTGATTACAACCGTAAACAGGCGGACGGTGCAGTG
GAACTGGAGAATGTTGAGTTAGCGCCACTGGTGGAGACAGTGGTTTCTGCTCATAGCCTGCCCGCACGGGCTAAAATGAT
GCATACCGACGTCGATCTCAAAGCAACTGCTTGCCTGGCGGAGCCAATGCTGCTGATGAGCGTACTGGATAATCTTTACT
CCAATGCGGTGCACTACGGGGCTGAATCCGGTAACATTTGCCTTCGCAGCAGTTTACATGGCGCGCGGGTTTATATTGAT
GTCATCAATACAGGCACACCCATTCCGCAAGAGGAACGCGCCATGATCTTCGAACCCTTTTTTCAGGGAAGCCACCAGCG
AAAAGGGGCGGTGAAGGGCAGCGGTCTGGGATTAAGCATTGCCAGGGATTGTATTCGCCGTATGCAGGGGGAACTGTATC
TGGTCGACGAGAGCGGGCAAGAGGTTTGCTTCCGCATTGAATTACCGTCGTCGAAAAACACGAAATAA

Upstream 100 bases:

>100_bases
CGCCTTATTCCATAACAAAGCCGGGTCATTCCCGGCTTTGTTGTATCTGAACTTCCCCTCGGTTAGCATCAGGCTATTCG
CGTCTGACGAGAGTAGCACC

Downstream 100 bases:

>100_bases
TGTTAAGAGCCTATCCCATCAGGCTATTTTATTTGCCAGTTTGGCCCCGTGCAGTGCTCGAAATCATTACGTACTACGTG
TACGCTCTGGTTTCTCCGCG

Product: sensory kinase in two-component system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDD
PTLAKVYQSQRKRYSEMLDAHAGVLPNDKLYQALRQDLNNLAQLQCNNSGPDAAAAARLEAFASANTEIVQATRTVVFSR
GQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLS
ERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADGAV
ELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYID
VINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQEVCFRIELPSSKNTK

Sequences:

>Translated_475_residues
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDD
PTLAKVYQSQRKRYSEMLDAHAGVLPNDKLYQALRQDLNNLAQLQCNNSGPDAAAAARLEAFASANTEIVQATRTVVFSR
GQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLS
ERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADGAV
ELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYID
VINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQEVCFRIELPSSKNTK
>Mature_475_residues
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEMERSYRQYCVLDD
PTLAKVYQSQRKRYSEMLDAHAGVLPNDKLYQALRQDLNNLAQLQCNNSGPDAAAAARLEAFASANTEIVQATRTVVFSR
GQQLQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLS
ERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADGAV
ELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYID
VINTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQEVCFRIELPSSKNTK

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=475, Percent_Identity=98.9473684210526, Blast_Score=966, Evalue=0.0,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=30.1694915254237, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87081816, Length=408, Percent_Identity=26.2254901960784, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=29.8245614035088, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=30.2127659574468, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789149, Length=354, Percent_Identity=24.2937853107345, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.004329004329, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=24.468085106383, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=24.1758241758242, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=232, Percent_Identity=31.8965517241379, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=26.9911504424779, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=24.6575342465753, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788549, Length=260, Percent_Identity=26.1538461538462, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=24.3243243243243, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=26.2096774193548, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=246, Percent_Identity=26.4227642276423, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53273; Mature: 53273

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTNAALEMERSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPNDKLYQALRQDLNN
HHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LAQLQCNNSGPDAAAAARLEAFASANTEIVQATRTVVFSRGQQLQREIAERGQYFGWQSL
HHHEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHH
VLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRN
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHH
LQKLIEQLLDYNRKQADGAVELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLA
HHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHH
EPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHH
FQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQEVCFRIELPSSKNTK
HCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MKRWPVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTNAALEMERSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPNDKLYQALRQDLNN
HHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LAQLQCNNSGPDAAAAARLEAFASANTEIVQATRTVVFSRGQQLQREIAERGQYFGWQSL
HHHEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHH
VLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRN
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHH
LQKLIEQLLDYNRKQADGAVELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLA
HHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHH
EPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHH
FQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQEVCFRIELPSSKNTK
HCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]