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The map label for this gene is hypC

Identifier: 218547764

GI number: 218547764

Start: 361914

End: 362186

Strand: Reverse

Name: hypC

Synonym: EFER_0349

Alternate gene names: 218547764

Gene position: 362186-361914 (Counterclockwise)

Preceding gene: 218547765

Following gene: 218547763

Centisome position: 7.89

GC content: 56.41

Gene sequence:

>273_bases
ATGTGCATAGGCGTTCCCGGCCAGATCCGCACCATTGACGGCAACCAGGCGAAAGTCGACGTCTGCGGTATTCAGCGCGA
CGTCGACCTAACGTTAGTCGGCAGCTGCGATGAAAACGGTCAGCCACGCGTGGGCCAGTGGGTACTGGTTCACGTTGGCT
TTGCCATGAGCGTAATTAATGAAGCCGAAGCGCGCGACACCCTCGACGCCTTACAAAACATGTTTGACGTTGAGCCGGAT
GTCGGCGCGCTGTTGTATGGCGAGGAAAAATAA

Upstream 100 bases:

>100_bases
CCTGCGCCCGCGAAGTCAATCCAGAAATTGAAATCATCCTTATTTCAGCCACCAGCGGCGAAGGGATGGACCAGTGGCTG
AACTGGCTGGAGACACAGCG

Downstream 100 bases:

>100_bases
TGCGTTTTGTTGATGAATATCGCGCGCCGGAACAGGTGATGCAGTTAATTGAGCATCTACGCGAACGTGCTTCACATCTC
TCTTACACCGCTGAACGCCC

Product: hydrogenase assembly chaperone

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD
VGALLYGEEK

Sequences:

>Translated_90_residues
MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD
VGALLYGEEK
>Mature_90_residues
MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD
VGALLYGEEK

Specific function: Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation

COG id: COG0298

COG function: function code O; Hydrogenase maturation factor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hupF/hypC family

Homologues:

Organism=Escherichia coli, GI1789083, Length=90, Percent_Identity=100, Blast_Score=184, Evalue=9e-49,
Organism=Escherichia coli, GI1789364, Length=81, Percent_Identity=56.7901234567901, Blast_Score=84, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYPC_ECO57 (P0AAM5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   H85921
- PIR:   H91076
- RefSeq:   NP_289278.1
- RefSeq:   NP_311611.1
- ProteinModelPortal:   P0AAM5
- SMR:   P0AAM5
- MINT:   MINT-1223075
- EnsemblBacteria:   EBESCT00000027852
- EnsemblBacteria:   EBESCT00000059363
- GeneID:   914694
- GeneID:   958189
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4037
- KEGG:   ecs:ECs3584
- GeneTree:   EBGT00050000009481
- HOGENOM:   HBG556935
- OMA:   FAMAKID
- ProtClustDB:   PRK10409
- BioCyc:   ECOL83334:ECS3584-MONOMER
- InterPro:   IPR019812
- InterPro:   IPR001109
- PRINTS:   PR00445
- TIGRFAMs:   TIGR00074

Pfam domain/function: PF01455 HupF_HypC

EC number: NA

Molecular weight: Translated: 9732; Mature: 9732

Theoretical pI: Translated: 3.96; Mature: 3.96

Prosite motif: PS01097 HUPF_HYPC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVIN
CEECCCCEEEEECCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHH
EAEARDTLDALQNMFDVEPDVGALLYGEEK
HHHHHHHHHHHHHHHCCCCCCCEEEEECCC
>Mature Secondary Structure
MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVIN
CEECCCCEEEEECCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHH
EAEARDTLDALQNMFDVEPDVGALLYGEEK
HHHHHHHHHHHHHHHCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796