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The map label for this gene is coaE [H]

Identifier: 218547559

GI number: 218547559

Start: 134453

End: 135073

Strand: Reverse

Name: coaE [H]

Synonym: EFER_0124

Alternate gene names: 218547559

Gene position: 135073-134453 (Counterclockwise)

Preceding gene: 218547561

Following gene: 218547558

Centisome position: 2.94

GC content: 48.31

Gene sequence:

>621_bases
ATGAGGTATACGGTAGCCTTAACGGGCGGTATTGGTAGTGGTAAAAGCACTGTTGCAAATGCGTTTGCCCGTCTCGGTAT
AAATATCATTGACGCTGATATTATTGCACGTCAGGTAGTTGAACCTGGAAAACCCGCGCTTAAGGCAATCGAAGAACATT
TTGGTCGTGAAATTATTGCTGAAGATGGGTCATTGAAACGGCGGGTTTTACGAGAACGAATATTTTCTCACCCGGAGGAG
AAAGCCTGGCTAAATGCCCTGCTTCATCCTTTGATTCAGCAGGAAACCCAGTGTCAGATTCAACGTGCAACTTCCCCTTA
CGTGTTATGGGTTGTGCCATTGCTGGTGGAAAACGCATTATATAAAAAAGCGAATCGTGTCCTCGTTATCGATGTCACGC
CAGAAACACAGCTCAAACGAACTATGCGGCGTGATGATGTTACGCGCGAGCATGTTGAACAAATTCTTGCTGCCCAGGCC
ACGCGTGACGCGCGCCTTGCCGTGGCAGACGACGTTATTGATAATAACGGCACAGCGGATGCGATTGCATCGGATGTCGC
CCACCTGCACGCGAAGTATTTACAACTCGCGGCGCAGTTTGTCTCACAGGAAAAACCATAA

Upstream 100 bases:

>100_bases
TTACCTGACGAATGGTAAGTACCATCCGCTTTAACGGCCATTTCCACCGTTTATTTTTTAACAAACTGATTAATATGTTT
AATTCCAGGAATATACATAT

Downstream 100 bases:

>100_bases
TGCTCACCCAGGTTCTTTTTGAACATCCTCTTAATGAAAAAATGCGCACATGGTTGCGTATTGAATTTCTGATTCAACAA
CTCTCCGTCAATCTGCCTGT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRYTVALTGGIGSGKSTVANAFARLGINIIDADIIARQVVEPGKPALKAIEEHFGREIIAEDGSLKRRVLRERIFSHPEE
KAWLNALLHPLIQQETQCQIQRATSPYVLWVVPLLVENALYKKANRVLVIDVTPETQLKRTMRRDDVTREHVEQILAAQA
TRDARLAVADDVIDNNGTADAIASDVAHLHAKYLQLAAQFVSQEKP

Sequences:

>Translated_206_residues
MRYTVALTGGIGSGKSTVANAFARLGINIIDADIIARQVVEPGKPALKAIEEHFGREIIAEDGSLKRRVLRERIFSHPEE
KAWLNALLHPLIQQETQCQIQRATSPYVLWVVPLLVENALYKKANRVLVIDVTPETQLKRTMRRDDVTREHVEQILAAQA
TRDARLAVADDVIDNNGTADAIASDVAHLHAKYLQLAAQFVSQEKP
>Mature_206_residues
MRYTVALTGGIGSGKSTVANAFARLGINIIDADIIARQVVEPGKPALKAIEEHFGREIIAEDGSLKRRVLRERIFSHPEE
KAWLNALLHPLIQQETQCQIQRATSPYVLWVVPLLVENALYKKANRVLVIDVTPETQLKRTMRRDDVTREHVEQILAAQA
TRDARLAVADDVIDNNGTADAIASDVAHLHAKYLQLAAQFVSQEKP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=194, Percent_Identity=37.6288659793814, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI191252795, Length=194, Percent_Identity=37.6288659793814, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI110227607, Length=162, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI110227605, Length=179, Percent_Identity=27.3743016759777, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110227603, Length=179, Percent_Identity=27.3743016759777, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110227601, Length=179, Percent_Identity=27.3743016759777, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI205277394, Length=179, Percent_Identity=27.3743016759777, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786292, Length=206, Percent_Identity=85.9223300970874, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17554944, Length=193, Percent_Identity=35.2331606217617, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320402, Length=182, Percent_Identity=37.3626373626374, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644728, Length=192, Percent_Identity=32.8125, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24658602, Length=162, Percent_Identity=29.0123456790123, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 22916; Mature: 22916

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTVALTGGIGSGKSTVANAFARLGINIIDADIIARQVVEPGKPALKAIEEHFGREIIA
CEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHH
EDGSLKRRVLRERIFSHPEEKAWLNALLHPLIQQETQCQIQRATSPYVLWVVPLLVENAL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YKKANRVLVIDVTPETQLKRTMRRDDVTREHVEQILAAQATRDARLAVADDVIDNNGTAD
HHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHH
AIASDVAHLHAKYLQLAAQFVSQEKP
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRYTVALTGGIGSGKSTVANAFARLGINIIDADIIARQVVEPGKPALKAIEEHFGREIIA
CEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHH
EDGSLKRRVLRERIFSHPEEKAWLNALLHPLIQQETQCQIQRATSPYVLWVVPLLVENAL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YKKANRVLVIDVTPETQLKRTMRRDDVTREHVEQILAAQATRDARLAVADDVIDNNGTAD
HHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHH
AIASDVAHLHAKYLQLAAQFVSQEKP
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]