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The map label for this gene is caiT [H]

Identifier: 218547487

GI number: 218547487

Start: 49586

End: 51100

Strand: Reverse

Name: caiT [H]

Synonym: EFER_0048

Alternate gene names: 218547487

Gene position: 51100-49586 (Counterclockwise)

Preceding gene: 218547497

Following gene: 218547486

Centisome position: 1.11

GC content: 51.88

Gene sequence:

>1515_bases
ATGACAAAAGAAAAGAAAAAAACGGGAATAGAACCGAAGGTGTTCTTTCCGCCATTAATAATCGTTGGCATACTTTGTTG
GCTTACAGTCAGAGATCTGGATGCGGCGAATGTCGTTATTAATGCTGTATTCAGTTACGTCACCAATGTATGGGGATGGG
CATTTGAATGGTATATGGTGGTAATGCTTTTCGGCTGGTTCTGGCTGGTATTCGGCCCGTATGCCAAAAAGCGTTTAGGT
AACGAACCGCCCGAGTTCAGTACCGCCAGTTGGATCTTTATGATGTTCGCCTCCTGTACCTCTGCCGCAGTACTGTTCTG
GGGGTCAATTGAGATCTACTACTACATCTCCACGCCACCATTTGCTTTAGAGCCAAACTCCACTGGCGCGAAAGAGTTGG
GGCTGGCCTACAGTTTGTTCCACTGGGGACCTCTACCGTGGGCCACTTACAGCTTCCTTTCCGTCGCCTTCGCGTACTTC
TTCTTTGTCCGCAAAATGGATGTGATTCGCCCCAGCTCCACTCTGGTGCCGCTGGTGGGTGAAAAACATGCCAAAGGCTT
GTTTGGCACTATCGTCGATAACTTCTATCTGGTAGCACTGATCTTCGCAATGGGCACCAGTCTGGGTCTTGCCACGCCGC
TGGTAACCGAGTGTATGCAGTGGTTGTTTGGTATTCCGCATACCCTGCAACTGGACGCCATTATCATTACCTGCTGGATC
ATCCTCAACGCTATCTGCGTGGCCTGTGGTCTGCAAAAAGGGGTAAAAATCGCCAGCGATGTGCGCAGCTATCTGAGTTT
CCTGATGCTCGGCTGGGTATTTATCGTCAGCGGCGCCAGCTTCATCATGAACTACTTCACCGACTCGGTGGGGATGTTGC
TGATGTATCTGCCGCGCATGTTGTTCTATACCGATGCCGTTGGCAAAGGCGGCTTCCCGCAGGGCTGGACCGTATTCTAC
TGGGCATGGTGGGTAATTTACGCTATCCAGATGAGTATCTTCCTTGCCCGCATCTCCCGTGGTCGTACCGTGCGTGAACT
GTGCTTCGGTATGGTGATGGGGCTGACAGCATCCACCTGGATCCTGTGGACTGTACTCGGCAGTAACACTCTGCTGTTGA
TGGATAAAAACATCATCAACATTCCAAATCTGATCGAACAGTACGGTGTCGCGCGCGCCATCATCGAAACCTGGGCCGCT
CTGCCGCTCAGCACTGCCACCATGTGGGGCTTCTTCATTCTCTGCTTTATTGCCACCGTTACCCTGATTAATGCCTGCTC
TTACACCCTGGCGATGTCCACCTGCCGCGAAGTGCGCGACGGCGAAGAACCACCGCTGCTGGTGCGTATCGGCTGGTCAA
TTCTGGTCGGCATTATCGGCATCGTTCTGTTGGCGCTCGGCGGCCTGAAACCGATTCAAACCGCCATTATCGCCGGAGGA
TGCCCGCTGTTCTTCGTCAATATTATGGTGACGCTCTCCTTTATAAAAGACGCGAAACAGAACTGGAAAGATTAA

Upstream 100 bases:

>100_bases
AACGCGTCCACGAGGTTAATAATAATTATATTAAATGTTAACAAAAATAAAACAAACGGGAACGCCAAATAAATATTTAT
TTTTACAGTGGAATTAACTC

Downstream 100 bases:

>100_bases
TTAACCCACAAAATATCAAGAGGTTGAAAGATGGATTTTAATTTAAATGATGAGCAGGAACTGTTTGTCGCCGGTATCCG
CGAACTGATGGCCAGCGAAA

Product: L-carnitine/gamma-butyrobetaine antiporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTKEKKKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLG
NEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFALEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYF
FFVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
ILNAICVACGLQKGVKIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDAVGKGGFPQGWTVFY
WAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAA
LPLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGG
CPLFFVNIMVTLSFIKDAKQNWKD

Sequences:

>Translated_504_residues
MTKEKKKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLG
NEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFALEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYF
FFVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
ILNAICVACGLQKGVKIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDAVGKGGFPQGWTVFY
WAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAA
LPLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGG
CPLFFVNIMVTLSFIKDAKQNWKD
>Mature_503_residues
TKEKKKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGN
EPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFALEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFF
FVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWII
LNAICVACGLQKGVKIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDAVGKGGFPQGWTVFYW
AWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAAL
PLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGC
PLFFVNIMVTLSFIKDAKQNWKD

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=504, Percent_Identity=97.6190476190476, Blast_Score=998, Evalue=0.0,
Organism=Escherichia coli, GI1788102, Length=438, Percent_Identity=29.2237442922374, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786506, Length=512, Percent_Identity=25, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 56515; Mature: 56384

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEKKKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPP
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCC
FALEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMDVIRPSSTLVPLVG
CEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
EKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
CHHHCHHHHHHHHHHHHHHHHHHHHCHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ILNAICVACGLQKGVKIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYTDAVGKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTW
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATV
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TLINACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGG
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
CPLFFVNIMVTLSFIKDAKQNWKD
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKEKKKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPP
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCC
FALEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMDVIRPSSTLVPLVG
CEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
EKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
CHHHCHHHHHHHHHHHHHHHHHHHHCHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ILNAICVACGLQKGVKIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYTDAVGKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTW
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATV
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TLINACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGG
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
CPLFFVNIMVTLSFIKDAKQNWKD
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA