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The map label for this gene is oadA [H]

Identifier: 218547468

GI number: 218547468

Start: 28476

End: 30257

Strand: Reverse

Name: oadA [H]

Synonym: EFER_0029

Alternate gene names: 218547468

Gene position: 30257-28476 (Counterclockwise)

Preceding gene: 218547469

Following gene: 218547467

Centisome position: 0.66

GC content: 53.09

Gene sequence:

>1782_bases
ATGACTATTTCCATTACTGACGTGGTCCTGCGCGATGCGCACCAATCTCTTTTCGCCACGCGTCTGCGCCTGGACGATAT
GCTCCCCATCGCCGCAGAACTCGATAACATCGGCTACGGTTCACTGGAGTGCTGGGGCGGTGCAACCTATGACGCCTGCA
TTCGCTTTCTGGGTGAAGATCCATGGGTCCGCCTGCGTGAACTGAAAAAAGCGATGCCGAAAACGCCGTTGCAGATGTTG
CTGCGCGGACAAAATCTCCTGGGTTATCGCCACTACGCTGACGACGTCGTGGAACGTTTCGTTGAACGCGCGGTGAAAAA
CGGCATGGATGTGTTCCGCGTTTTCGATGCGATGAACGATCCACGCAATATGCAGGCAGCGTTGCGTGCTGTACGGAGCC
ATGGTGCTCACGCTCAGGGAACGCTCTCCTACACCACAAGCCCGGTACATACCCTGCAAACCTGGCTGGATCTGACTGAG
CAGTTACTGGAGATCGGCGTAGACTCTATCGCTATTAAAGATATGTCGGGCATTCTGACACCAGGTGCATCCTGGGAACT
GGTTCACGCAATTAAACAGCGTTATGACGTGAAACTGCATCTGCATTGCCACGCCACTACCGGGATGGCAGAGATGGCAC
TGTTGAAAGCTATCGAAGCAGGTGTAGATGGTGTTGATACGGCAATATCTTCAATGAGTGCCACCTACGCCCATCCTGCA
ACTGAAGCCCTGGTCGCCACACTTGCCGGAACGGAATTCGATACCGGACTGGATATTCAACGTCTGGAAAAAATCGCAGC
TTATTTCCGCGATGTACGCAAGAAATACCATGCGTTTGAAGGCCAGTTGAAAGGTTACGACAGCCGTATTCTGGTGGCAC
AAGTGCCAGGTGGCATGTTGACCAACCTTGAAAGCCAGCTGAAACAGCAAAATGCTTCCGACAAACTGGATGCTGTGCTG
AGCGAGATTCCACGCGTGCGTGAAGATCTGGGCTTTATCCCGCTGGTTACACCAACCTCTCAAATTGTTGGTACTCAGGC
GGTACTTAATGTTCTGACGGGTGAGCGTTATAAAACTATTGCTAAAGAAACTGCTGGCATTCTGAAAGGTGAGTATGGCC
TGACGCCTGCTCCGGTAAACGCGGCTCTGCAGGCTGAAGTGTTAAAAGGCGACGTCGCTATCACTTGTCGCCCCGCCGAT
CTGCTGAAACCTGAACTGGCACAACTGGAAGAGGAAGTGAAACGCCAGGCAGCAGAAAAAGGTATCAAACTTGCTGGTAA
CGCCATTGACGACGTGCTGACAGTTGCCCTGTTCCCACAAATTGGGCTGAAATTCCTCGAAAATCGCGGAAATCCGGCAG
CATTTGAACCGGTACCGCAGATTGAAAGTACTCGTCCGGCAGAACCTGCGAAAACTGAAGCAAAAGCGCCATCTTCTTCT
GGAATTTACACCGTTGAAGTTGAAGGCAAAGCTTTTGTGGTGAAAGTAAGCGAAGGTGGCGACATTCAGCAAGTTGCCAC
CACGACCGTCGCTCAACCTTCCGCACCAGCTGCCGCACCTGCCGGGAGTGGTACTCCGGTAACCGCACCGCTGGCCGGGA
ATATCTGGAAAATCATCGCTACCGAAGGACAAAGCGTCGCTGAAGGTGATGTGCTGCTGATCCTTGAAGCGATGAAAATG
GAAACCGAGATCCGCGCTGCACAGGCGGGAACTGTTCGTGGTATTGCGGTCAAGGCCGGAGACGCCGTTGCGGTTGGCGA
TACCCTGATGACGCTGGCGTAA

Upstream 100 bases:

>100_bases
TACCGCTGCACCAGCTGATGATTTCAGCCGCCTGAAGCCGGTAATCGCTGCCGCCATTCATCATCATCGCCGTCTTAATT
CGTAATTCAGGGAGGAACCT

Downstream 100 bases:

>100_bases
CGGAGAACTGAGATGGATAGTCTGAATGCCCTGATTCAGGGTATGGGGCTGATGCACCTCAGCGCTGGACAGGCCGTGAT
GTTGCTGGTCAGTCTGGTGC

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTISITDVVLRDAHQSLFATRLRLDDMLPIAAELDNIGYGSLECWGGATYDACIRFLGEDPWVRLRELKKAMPKTPLQML
LRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMNDPRNMQAALRAVRSHGAHAQGTLSYTTSPVHTLQTWLDLTE
QLLEIGVDSIAIKDMSGILTPGASWELVHAIKQRYDVKLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYAHPA
TEALVATLAGTEFDTGLDIQRLEKIAAYFRDVRKKYHAFEGQLKGYDSRILVAQVPGGMLTNLESQLKQQNASDKLDAVL
SEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLTGERYKTIAKETAGILKGEYGLTPAPVNAALQAEVLKGDVAITCRPAD
LLKPELAQLEEEVKRQAAEKGIKLAGNAIDDVLTVALFPQIGLKFLENRGNPAAFEPVPQIESTRPAEPAKTEAKAPSSS
GIYTVEVEGKAFVVKVSEGGDIQQVATTTVAQPSAPAAAPAGSGTPVTAPLAGNIWKIIATEGQSVAEGDVLLILEAMKM
ETEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA

Sequences:

>Translated_593_residues
MTISITDVVLRDAHQSLFATRLRLDDMLPIAAELDNIGYGSLECWGGATYDACIRFLGEDPWVRLRELKKAMPKTPLQML
LRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMNDPRNMQAALRAVRSHGAHAQGTLSYTTSPVHTLQTWLDLTE
QLLEIGVDSIAIKDMSGILTPGASWELVHAIKQRYDVKLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYAHPA
TEALVATLAGTEFDTGLDIQRLEKIAAYFRDVRKKYHAFEGQLKGYDSRILVAQVPGGMLTNLESQLKQQNASDKLDAVL
SEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLTGERYKTIAKETAGILKGEYGLTPAPVNAALQAEVLKGDVAITCRPAD
LLKPELAQLEEEVKRQAAEKGIKLAGNAIDDVLTVALFPQIGLKFLENRGNPAAFEPVPQIESTRPAEPAKTEAKAPSSS
GIYTVEVEGKAFVVKVSEGGDIQQVATTTVAQPSAPAAAPAGSGTPVTAPLAGNIWKIIATEGQSVAEGDVLLILEAMKM
ETEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA
>Mature_592_residues
TISITDVVLRDAHQSLFATRLRLDDMLPIAAELDNIGYGSLECWGGATYDACIRFLGEDPWVRLRELKKAMPKTPLQMLL
RGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMNDPRNMQAALRAVRSHGAHAQGTLSYTTSPVHTLQTWLDLTEQ
LLEIGVDSIAIKDMSGILTPGASWELVHAIKQRYDVKLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYAHPAT
EALVATLAGTEFDTGLDIQRLEKIAAYFRDVRKKYHAFEGQLKGYDSRILVAQVPGGMLTNLESQLKQQNASDKLDAVLS
EIPRVREDLGFIPLVTPTSQIVGTQAVLNVLTGERYKTIAKETAGILKGEYGLTPAPVNAALQAEVLKGDVAITCRPADL
LKPELAQLEEEVKRQAAEKGIKLAGNAIDDVLTVALFPQIGLKFLENRGNPAAFEPVPQIESTRPAEPAKTEAKAPSSSG
IYTVEVEGKAFVVKVSEGGDIQQVATTTVAQPSAPAAAPAGSGTPVTAPLAGNIWKIIATEGQSVAEGDVLLILEAMKME
TEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=628, Percent_Identity=32.9617834394904, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI106049295, Length=628, Percent_Identity=32.9617834394904, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI106049292, Length=628, Percent_Identity=32.9617834394904, Blast_Score=286, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17562816, Length=629, Percent_Identity=33.7042925278219, Blast_Score=303, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6319695, Length=633, Percent_Identity=32.0695102685624, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6321376, Length=637, Percent_Identity=30.7692307692308, Blast_Score=292, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24652212, Length=634, Percent_Identity=32.807570977918, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24652210, Length=634, Percent_Identity=32.807570977918, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24652214, Length=634, Percent_Identity=32.807570977918, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI19921944, Length=634, Percent_Identity=32.807570977918, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24652216, Length=634, Percent_Identity=32.807570977918, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI281363050, Length=633, Percent_Identity=32.7014218009479, Blast_Score=288, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24652224, Length=633, Percent_Identity=32.7014218009479, Blast_Score=288, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24652222, Length=633, Percent_Identity=32.7014218009479, Blast_Score=288, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24652220, Length=633, Percent_Identity=32.7014218009479, Blast_Score=288, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24652218, Length=633, Percent_Identity=32.7014218009479, Blast_Score=288, Evalue=8e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 63691; Mature: 63560

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISITDVVLRDAHQSLFATRLRLDDMLPIAAELDNIGYGSLECWGGATYDACIRFLGED
CEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEECCCCCCHHHHHHHHCCC
PWVRLRELKKAMPKTPLQMLLRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMND
CHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PRNMQAALRAVRSHGAHAQGTLSYTTSPVHTLQTWLDLTEQLLEIGVDSIAIKDMSGILT
CHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCC
PGASWELVHAIKQRYDVKLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYAHPA
CCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
TEALVATLAGTEFDTGLDIQRLEKIAAYFRDVRKKYHAFEGQLKGYDSRILVAQVPGGML
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHH
TNLESQLKQQNASDKLDAVLSEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLTGERYKTI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCHHHHHH
AKETAGILKGEYGLTPAPVNAALQAEVLKGDVAITCRPADLLKPELAQLEEEVKRQAAEK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHC
GIKLAGNAIDDVLTVALFPQIGLKFLENRGNPAAFEPVPQIESTRPAEPAKTEAKAPSSS
CCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GIYTVEVEGKAFVVKVSEGGDIQQVATTTVAQPSAPAAAPAGSGTPVTAPLAGNIWKIIA
CEEEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEEEE
TEGQSVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA
ECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHCC
>Mature Secondary Structure 
TISITDVVLRDAHQSLFATRLRLDDMLPIAAELDNIGYGSLECWGGATYDACIRFLGED
EEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEECCCCCCHHHHHHHHCCC
PWVRLRELKKAMPKTPLQMLLRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMND
CHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PRNMQAALRAVRSHGAHAQGTLSYTTSPVHTLQTWLDLTEQLLEIGVDSIAIKDMSGILT
CHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCC
PGASWELVHAIKQRYDVKLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYAHPA
CCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
TEALVATLAGTEFDTGLDIQRLEKIAAYFRDVRKKYHAFEGQLKGYDSRILVAQVPGGML
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHH
TNLESQLKQQNASDKLDAVLSEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLTGERYKTI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCHHHHHH
AKETAGILKGEYGLTPAPVNAALQAEVLKGDVAITCRPADLLKPELAQLEEEVKRQAAEK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHC
GIKLAGNAIDDVLTVALFPQIGLKFLENRGNPAAFEPVPQIESTRPAEPAKTEAKAPSSS
CCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GIYTVEVEGKAFVVKVSEGGDIQQVATTTVAQPSAPAAAPAGSGTPVTAPLAGNIWKIIA
CEEEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEEEE
TEGQSVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA
ECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]